Huda Akil

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A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats

Fergal J. Martin, J. Sebat, W. Chow, 2023, bioRxiv.

Inhibition of dopamine neurons prevents incentive value encoding of a reward cue: With revelations from deep phenotyping

K. Deisseroth, C. Burgess, Fei Li, 2023, bioRxiv.

Extensive profiling of transcription factors in postmortem brains defines genomic occupancy in disease-relevant cell types and links TF activities to neuropsychiatric disorders

G. Cooper, W. Bunney, B. Bunney, 2023, bioRxiv.

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

Manuel A. R. Ferreira, John P. Rice, Edward G. Jones, 2011, Nature Genetics.

Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder

R. Myers, S. Potkin, H. Akil, 2015, Translational Psychiatry.

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

R. Myers, Jun Z. Li, H. Akil, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors

R. Myers, H. Akil, W. Bunney, 2019, Translational Psychiatry.

Environmental context and drug history modulate amphetamine-induced c-fos mrna expression in the basal ganglia, central extended amygdala, and associated limbic forebrain

T. Robinson, H. Akil, S. Watson, 2003, Neuroscience.

Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder

R. Myers, Jun Z. Li, H. Akil, 2014, Molecular Psychiatry.

Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal

H. Akil, G. McNally, Huda Akil, 2002, Neuroscience.

Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization- receptor autoradiographic analysis

H. Akil, J. Meador-Woodruff, O. Civelli, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Synthesis and characterization of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-labeled fluorescent ligands for the mu opioid receptor.

H. Akil, P. Emmerson, A. Mansour, 1997, Biochemical pharmacology.

5'-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus.

H. Akil, S. Watson, R. Thompson, 1993, Endocrinology.

Dysregulation of the fibroblast growth factor system in major depression.

E G Jones, R. Myers, H. Akil, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder

S. Potkin, A. Schatzberg, B. Rollins, 2015, Translational Psychiatry.

Behavioral neurochemistry: neuroregulators and behavioral states.

H. Akil, S. Watson, J. Barchas, 1978, Science.

Rare coding variants in 10 genes confer substantial risk for schizophrenia

S. Gabriel, J. Suvisaari, T. Paunio, 2023 .

Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry

D. Absher, P. Muglia, M. Boehnke, 2009, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders

R. Myers, H. Akil, B. Bolstad, 2006, Molecular Psychiatry.

Mitochondrial related gene expression changes are sensitive to agonal-pH state

R. Myers, H. Akil, B. Bolstad, 2006, Molecular Psychiatry.

Loss of glucocorticoid fast feedback in depression.

H. Akil, E. Young, S. Watson, 1991, Archives of general psychiatry.

Stress-induced changes in primate prefrontal profiles of gene expression

D. M. Lyons, R. Myers, H. Akil, 2007, Molecular Psychiatry.

Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors

H. Akil, S. Watson, J. Nicholson, 2002, Neuroscience.

Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic–hypothalamic–pituitary–adrenal axis

H. Akil, S. Watson, D. Devine, 2001, Neuroscience.

Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis.

F. Monsma, H. Akil, O. Civelli, 1998, Molecular pharmacology.

Multiple HPA profiles in endogenous depression: Effect of age and sex on cortisol and beta-endorphin

H. Akil, E. Young, L. Grunhaus, 1993, Biological Psychiatry.

Controlling signaling with a specifically designed Gi-coupled receptor.

H. Akil, B. Conklin, P. Coward, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Direct evidence of nitric oxide presence within mitochondria.

H. Akil, S. Watson, L. Rønn, 2000, Biochemical and biophysical research communications.

Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype

M. Hagenauer, P. Maras, E. Hebda-Bauer, 2024, bioRxiv.

Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation

L. DeLisi, R. Myers, E. G. Jones, 2009, BMC Medical Genomics.

Registered in England and Wales Registered Number : 1072954 Registered office :

M. Vawter, A. Schatzberg, Huda Akil, 2008 .

Cell-Type Specific Reductions in Interneuron Gene Expression within Subregions of the Anterior and Posterior Cingulate Gyrus of Schizophrenia and Bipolar Disorder Subjects

A. Schatzberg, B. Bunney, M. Waselus, 2024, bioRxiv.

The search for the neurobiological basis of vulnerability to drug abuse: using microarrays to investigate the role of stress and individual differences

H. Akil, S. Watson, S. Evans, 2004, Neuropharmacology.

Forebrain glucocorticoid receptor overexpression increases environmental reactivity and produces a stress-induced spatial discrimination deficit

E. Hebda-Bauer, A. Pletsch, Huda Akil, 2010, Neuroscience.

Multiomic profiling of transcription factor binding and function in human brain.

B. Bunney, P. Cartagena, Belle A Moyers, 2024, Nature neuroscience.

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

Madeline, Melissa J. Green, Janice M. Fullerton, 2017 .

Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

Hoang T. Nguyen, R. Ophoff, V. Willour, 2021, Molecular Psychiatry.

Gender Specific Disruptions in Emotion Processing in Younger Adults with Depression Gender Specific Disruptions in Emotion Processing in Younger Adults with Depression

S. Langenecker, Allison M. Kade, P. Deldin, 2022 .