L. He

A common pharmacophore for cytotoxic natural products that stabilize microtubules.

S. Kuduk, S. Chakravarty, S. Danishefsky, 1999, Proceedings of the National Academy of Sciences of the United States of America.

A common pharmacophore for Taxol and the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain.

D. Kingston, S. Horwitz, P. Jagtap, 2000, Biochemistry.

Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.

M. Kavallaris, M. Haber, M. Norris, 2001, Cancer research.

Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel.

S. Baker, M. O. Bradley, P. Devanesan, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments.

T. Chou, S. Stachel, S. Danishefsky, 2000, Organic letters.

The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.

Amos B. Smith, S. Horwitz, M. LaMarche, 2001, Chemistry & biology.

Structure-activity studies on 4-substituted-2-anilinopyrimidine corticotropin releasing factor (CRF) antagonists.

Y. Wong, L. Fitzgerald, S. Tam, 1999, Bioorganic & medicinal chemistry.

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist.

S. Shelton, G. Trainor, P. Hartig, 2000, Journal of medicinal chemistry.

Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines.

E. D. De Souza, F. Hobbs, A. Cocuzza, 1999, Journal of medicinal chemistry.

Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.

S. Horwitz, C. Yang, L. He, 2001, Molecular cancer therapeutics.