K. Watanabe

发表

Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug.

D. Rottenberg, R. Price, K. Watanabe, 1982, Science.

Synthesis and purification of the anti-viral agent 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) labeled with iodine-125.

P. Conti, K. Watanabe, M. Perlman, 1984, International journal of nuclear medicine and biology.

2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent

K. Watanabe, J. Fox, C. López, 1980, Antimicrobial Agents and Chemotherapy.

Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.

K. Watanabe, J. Fox, C. López, 1979, Journal of medicinal chemistry.

Aliphatic and alicyclic diols induce melanogenesis in cultured cells and guinea pig skin.

A. Khorlin, K. Watanabe, W. Ren, 1998, The Journal of investigative dermatology.

Intercalating agents with covalent bond forming capability. A novel type of potential anticancer agents. 2. Derivatives of chrysophanol and emodin.

T R Kelly, T. Chou, Z. Darżynkiewicz, 1989, Journal of medicinal chemistry.

Activity of 2-fluoro-5-methylarabinofuranosyluracil against mouse leukemias sensitive to and resistant to 1-beta-D-arabinofuranosylcytosine.

J. Burchenal, T. Chou, K. Watanabe, 1982, Cancer research.

Structural Requirements for the Enzymatic Deamination of Cytosine Nucleosides

K. Watanabe, W. Kreis, J. Fox, 1978 .

Nucleosides. 100. General synthesis of pyrimidine C-5 cucleosides related to pseudouridine. Synthesis of 5-(beta-D-ribofuranosyl) isocytosine (pseudoisocytidine),5-(beta-D-ribofuranosyl)-2-thiouracil(2-thiopseudouridine) and 5-(beta-D-ribofuranosyl)uracil(pseudouridine).

C. K. Chu, K. Watanabe, J. Fox, 1976, The Journal of organic chemistry.

Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine

T. Chou, E. Muchmore, X. Kong, 1992, Antimicrobial Agents and Chemotherapy.

Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.

H. Li, K. Watanabe, K. Pankiewicz, 1995, Biochemistry.

Nucleosides. 68. Synthetic studies on nucleoside antibiotics. 5. 4-amino-2,3-unsaturated sugars related to the carbohydrate moiety of blasticidin S.

R. Goody, K. Watanabe, J. Fox, 1970, Tetrahedron.

Nucleoside antibiotics.

K. Watanabe, J. Fox, A. Bloch, 1966, Progress in nucleic acid research and molecular biology.

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.

E. Levine, K. Watanabe, K. O. Tankersley, 1996, Proceedings of the National Academy of Sciences of the United States of America.

How do the aglycones drive the pseudorotational equilibrium of the pentofuranose moiety in C-nucleosides?

J. Plavec, K. Watanabe, J. Chattopadhyaya, 1994 .

Synthesis of the acridone alkaloids glyfoline and congeners. Structure-activity relationship studies of cytotoxic acridones.

T. Chou, M. Chun, K. Watanabe, 1992, Journal of medicinal chemistry.

Synthesis of 3-methylpseudouridine and 2'-deoxy-3-methyl-pseudouridine.

A. Matsuda, K. Watanabe, K. Pankiewicz, 1982, Carbohydrate research.

Antileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside.

J. Burchenal, C. K. Chu, T. O'Toole, 1976, Cancer Research.

Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil.

T. Chou, K. Watanabe, J. Matulić-Adamić, 1988, Journal of medicinal chemistry.

Nucleosides. 38. Proton magnetic resonance studies of acetylated nucleosides.

K. Watanabe, R. J. Cushley, J. Fox, 1967, Journal of the American Chemical Society.

Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.

G. Gilliland, G. Xiao, J. Stivers, 1999, Biochemistry.

Kinetics and substrate specificity of human and canine cytidine deaminase.

T. Chou, K. Watanabe, M. Fanucchi, 1986, Biochemical pharmacology.

Effect of derivatives of chrysophanol, a new type of potential antitumor agents of anthraquinone family, on growth and cell cycle of L1210 leukemic cells.

Z. Darżynkiewicz, S. Carter, J. Kapuściński, 1989, Cancer letters.

Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2

R. Schinazi, K. Watanabe, A. Nahmias, 1986, Antimicrobial Agents and Chemotherapy.

Mechanism of action of 2',5-difluoro-1-arabinosyluracil.

D. Santi, J. Coderre, J. Fox, 1983, Journal of medicinal chemistry.

Incorporation of metabolites of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues.

T. Chou, K. Watanabe, A. Grant, 1982, Biochemical pharmacology.

Activity of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)thymine against herpes simplex virus in cell cultures and rabbit eyes

A. Nesburn, K. Watanabe, M. Trousdale, 1983, Antimicrobial Agents and Chemotherapy.

Pharmacological disposition and metabolic fate of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mice and rats.

T. Chou, P. Vidal, K. Watanabe, 1981, Cancer research.

Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases

Y. Cheng, K. Watanabe, G. Dutschman, 1981, Antimicrobial Agents and Chemotherapy.

Evaluation of the antiherpetic activity of 2'-fluoro-5-iodo-ara-C in rabbit eyes and cell cultures.

A. Nesburn, K. Watanabe, M. Trousdale, 1981, Investigative ophthalmology & visual science.

Solvation effects on conformational equilibria. Studies related to the conformational properties of 2-methoxytetrahydropyran and related methyl glycopyranosides

J. C. Martin, A. Pavia, K. Watanabe, 1969 .

Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase.

J. Stivers, K. Watanabe, K. Pankiewicz, 1999, Biochemistry.

Synthesis of 2'-fluoro-5-[11C]-methyl-1-beta-D-arabinofuranosyluracil ([11C]-FMAU): a potential nucleoside analog for in vivo study of cellular proliferation with PET.

P. Conti, K. Watanabe, M. Alauddin, 1995, Nuclear medicine and biology.

NUCLEOSIDES. 129. SYNTHESIS OF ANTIVIRAL NUCLEOSIDES: 5-ALKENYL-1-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)URACILS

K. Watanabe, T. Su, J. Fox, 1984 .

Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils.

K. Watanabe, T. Su, J. Fox, 1984, Journal of medicinal chemistry.

Cell differentiation effects of 2'-fluoro-1-beta-D-arabinofuranosyl pyrimidines in HL-60 cells.

T. Chou, M. Andreeff, X. Kong, 1987, Leukemia research.

9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.

T. Chou, F. Sirotnak, K. Watanabe, 1995, Journal of medicinal chemistry.

Nucleosides. 146. 1-Methyl-5-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil, the C-nucleoside isostere of the potent antiviral agent 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)thymine (FMAU). Studies directed toward the synthesis of 2'-deoxy-2'-substituted arabino nucleosides. 6.

B. Nawrot, K. Watanabe, K. Pankiewicz, 1987, Journal of medicinal chemistry.

Nucleosides. CXLIII. Synthesis of 5'-deoxy-5'-substituted-2,2'-anhydro-1-(beta-D-arabinofuranosyl) uracils. A new 2,5'- to 2,2'-anhydro-nucleoside transformation. Studies directed toward the synthesis of 2'-deoxy-2'-substituted arabino nucleosides. (4).

K. Watanabe, K. Pankiewicz, K. Watanabe, 1987, Chemical & pharmaceutical bulletin.

Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-beta-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships.

A. Matsuda, M. Chun, C. K. Chu, 1983, Journal of medicinal chemistry.

A practical synthesis of 2-deoxy-2-fluoro-D-arabinofuranose derivatives.

K. Watanabe, J. Fox, U. Reichman, 1975, Carbohydrate research.

Novel type of potential anticancer agents derived from chrysophanol and emodin. Some structure-activity relationship studies.

K. Watanabe, T. R. Kelly, M. Koyama, 1988, Journal of medicinal chemistry.

Nucleosides XXXII. On the Structure of blasticidin S, a nucleoside antibiotic.

K. Watanabe, J. Fox, K. Watanabe, 1966, Tetrahedron letters.

Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks

C. Trépo, B. Chomel, K. Watanabe, 1990, Antimicrobial Agents and Chemotherapy.

Synergistic inhibition of human immunodeficiency virus type 1 replication in vitro by two-drug and three-drug combinations of 3'-azido-3'-deoxythymidine, phosphonoformate, and 2',3'-dideoxythymidine

T. Chou, X. Kong, Q. Y. Zhu, 1991, Antimicrobial Agents and Chemotherapy.

A Simple Method for Selective Acylation of Cytidine of the 4-Amino Group†

K. Watanabe, J. Fox, K. Watanabe, 1966 .

Novel mycophenolic adenine bis(phosphonate)s as potential immunosuppressants.

K. Pankiewicz, K. Malinowski, K. Lesiak-watanabe, 1999, Current medicinal chemistry.

Synthesis of 2′‐Deoxy‐2′‐fluoro‐1‐β‐D‐arabinofuranosyl Uracil Derivatives: A Method Suitable for Preparation of [18F]‐Labeled Nucleosides.

P. Conti, M. Alauddin, J. Fissekis, 2002 .

Metabolism and effects of 5-(beta-D-ribofuranosyl)isocytosine in P815 cells.

J. Burchenal, T. Chou, C. K. Chu, 1979, Cancer research.

Nucleosides. LXVI. Synthetic studies on nucleoside antibiotics. 4. Synthesis of methyl 4-amino-2,3,4-trideoxy-alpha-D-erythro-hex-2-enopyranosiduronic acid, the carbohydrate moiety of blasticidin S.

R. Goody, J. Fox, K. Watanabe, 1970, Tetrahedron Letters.

Nucleosides. LIX. Synthetic studies on nucleoside antibiotics. 1. Synthesis of 1-(4-amino-4-deoxy-beta-D-glucopyranosyl)cytosines and their identity with products derived from Gougerotin.

K. Watanabe, J. Fox, M. Kotick, 1969, Chemical & pharmaceutical bulletin.

Preparation of unsaturated carbohydrates. A facile synthesis of methyl 4,6-O-Benzylidene-D-hex-2-enopyranosides

K. Watanabe, R. Lemieux, E. Fraga, 1968 .

Nucleosides. CXIX. Substrate specificity and mechanism of action of cytidine deaminases of monkey plasma and mouse kidney.

T. Chou, K. Watanabe, J. Fox, 1981, Chemico-biological interactions.

Effects of certain nucleoside analogues on human cytomegalovirus replication in vitro.

E. Huang, Y. Cheng, K. Watanabe, 1984, The Journal of general virology.

Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogues of 2'-fluoroarabinosylpyrimidine nucleosides.

R. Schinazi, K. Watanabe, J. Matulić-Adamić, 1987, Journal of medicinal chemistry.

Cytotoxic and non-cytotoxic N-alkyl derivatives of putrescine: effect on polyamine uptake and growth of prostatic cancer cells in vitro.

K. Watanabe, W. Heston, D. Covey, 1987, Biochemical pharmacology.

Nucleosides. 114. 5'-O-Glucuronides of 5-fluorouridine and 5-fluorocytidine. Masked precursors of anticancer nucleosides.

A. Matsuda, K. Watanabe, J. Fox, 1981, Journal of medicinal chemistry.

Cytocidal effect of gossypol on cultured murine erythroleukemia cells is prevented by serum protein.

K. Watanabe, M. Sonenberg, Y. Ren, 1984, The Journal of pharmacology and experimental therapeutics.

NUCLEOSIDES PART 92, A FACILE SYNTHESIS OF 5‐(BETA‐D‐RIBOFURANOSYL)‐ISOCYTOSINE(PSI‐ISOCYTIDINE)

C. K. Chu, J. Fox, K. Watanabe, 1975 .

Nucleosides. CXLVIII. Synthesis of 6-(beta-D-ribofuranosyl)picolinamide. A novel C-nucleoside from D-ribonolactone.

K. Watanabe, E. Sochacka, K. Pankiewicz, 1988, Chemical & pharmaceutical bulletin.

Synthesis and anti-HIV-1 activity of 2'-"up"-fluoro analogues of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC).

T. Chou, Q. Y. Zhu, K. Watanabe, 1990, Journal of medicinal chemistry.

2'-azido-2',3'-dideoxypyrimidine nucleosides. Synthesis and antiviral activity against human immunodeficiency virus.

J. A. Warshaw, K. Watanabe, 1990, Journal of medicinal chemistry.

A Simple Multi-Gram Synthesis of 5′-Hydrogenphosphonates and 5′-Phosphorofluoridates of Sugar Modified Nucleosides

K. Watanabe, A. Krayevsky, A. Arzumanov, 1993 .