P. Witt‐Enderby

发表

Microtubules modulate melatonin receptors involved in phase‐shifting circadian activity rhythms: in vitro and in vivo evidence

M. J. Jarzynka, Deepshikha K Passey, David A. Johnson, 2009, Journal of pineal research.

Platelet-rich preparations to improve healing. Part I: workable options for every size practice.

Nicholas M. Radio, P. Witt-Enderby, W. Clafshenkel, 2014, The Journal of oral implantology.

Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs

U. Holzgrabe, P. Witt-Enderby, S. Elliott, 2019, Molecular Pharmacology.

Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT1 selectivity

D. Zlotos, Noura M. Riad, B. Dodda, 2015 .

Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.

Deepshikha K Passey, M. Melan, P. Witt-Enderby, 2002, Biochemical pharmacology.

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

Oxana V. Baranova, T. Lezon, Xiaomin Wang, 2017, Proceedings of the National Academy of Sciences.

Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways

R. Jockers, Nicholas M. Radio, Yau-Huei Wei, 2010, Journal of pineal research.

High affinity nuclear and nongenomic estradiol binding sites in the human and mouse lens.

P. Witt-Enderby, Katie M. Gallagher, V. Davis, 2013, Experimental eye research.

Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms *

J. Benovic, P. Witt-Enderby, R. Pals-Rylaarsdam, 1995, The Journal of Biological Chemistry.

Melatonin receptor ligands: A pharmaco‐chemical perspective

C. Sotriffer, J. Boutin, P. Witt-Enderby, 2020, Journal of pineal research.

MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

E. Cecon, R. Jockers, P. Witt-Enderby, 2014, Journal of medicinal chemistry.

Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives

M. Melan, P. Witt-Enderby, J. Latimer, 2009, Expert Reviews in Molecular Medicine.

DARK Classics in Chemical Neuroscience: Ibogaine.

P. Witt-Enderby, C. K. Surratt, Michael J. Wasko, 2018, ACS chemical neuroscience.

Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin‐mediated osteoblastogenesis

A. V. van Wijnen, A. Dudakovic, P. Witt-Enderby, 2018, Journal of pineal research.

Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure.

M. J. Jarzynka, P. Witt-Enderby, J. W. Clemens, 2001, Life sciences.

Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.

P. Witt-Enderby, M. Dubocovich, P. Witt‐Enderby, 1996, Molecular pharmacology.

Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade

Nicholas M. Radio, P. Witt-Enderby, J. Doctor, 2006, Journal of pineal research.

Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy

Nicholas M. Radio, P. Witt-Enderby, J. Doctor, 2006, Journal of pineal research.

Melatonin effects on bone: Implications for use as a therapy for managing bone loss

P. Witt-Enderby, Fahima Munmun, P. Witt‐Enderby, 2021, Journal of pineal research.

Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone‐grafting procedures

P. Witt-Enderby, S. Maria, P. Witt‐Enderby, 2014, Journal of pineal research.

Effects on bone by the light/dark cycle and chronic treatment with melatonin and/or hormone replacement therapy in intact female mice

P. Witt-Enderby, W. Clafshenkel, M. Kotlarczyk, 2012, Journal of pineal research.

Relationship between melatonin and bone resorption rhythms in premenopausal women

Shadab A. Rahman, S. Lockley, P. Witt-Enderby, 2017, Journal of Bone and Mineral Metabolism.

Circadian Regulation of Bone

P. Witt-Enderby, S. Maria, P. Witt‐Enderby, 2017 .

Platelet-rich preparations to improve healing. Part II: platelet activation and enrichment, leukocyte inclusion, and other selection criteria.

Nicholas M. Radio, P. Witt-Enderby, W. Clafshenkel, 2014, The Journal of oral implantology.

Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization.

M. J. Jarzynka, M. Melan, P. Witt-Enderby, 2004, Life sciences.

The effect of caffeine and choline on short term memory

P. Witt-Enderby, Natasha Nagrecha, Jamie L. McConaha, 2011 .

Mini-review: CNS Melatonin Receptors and Signaling: Focus on Aging-Related Diseases and Future Perspectives

Jane E. Cavanaugh, P. Witt-Enderby, P. Witt‐Enderby, 2010 .

Myths and Evidence Regarding Melatonin Supplementation for Occasional Sleeplessness in the Pediatric Population.

R. Goldman, P. Witt-Enderby, J. Olcese, 2021, Pediatric annals.

The role of MEK1/2 and MEK5 in melatonin‐mediated actions on osteoblastogenesis, osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation

P. Witt-Enderby, M. Burow, O. Mohiuddin, 2022, Journal of pineal research.

Study assessing the efficacy of herbal teas on bone health and quality of life in a population with osteopenia: rooibos actions on melatonin and tulsi actions on quality of life.

P. Witt-Enderby, Fahima Munmun, A. Linden, 2021 .

The effect of estradiol, progesterone, and melatonin on estrous cycling and ovarian aromatase expression in intact female mice.

C. Alonso-González, P. Witt-Enderby, E. Sánchez-Barceló, 2014, European journal of obstetrics, gynecology, and reproductive biology.

Alternative Options to Manage Menopausal Symptoms with a Focus on Melatonin and Osteoporosis

P. Witt-Enderby, N. Johns, J. Johns, 2014 .

A novel calcium aluminate‐melatonin scaffold enhances bone regeneration within a calvarial defect

Rachelle N. Palchesko, P. Witt-Enderby, E. Gawalt, 2012, Journal of pineal research.

Melatonin osteoporosis prevention study (MOPS): a randomized, double‐blind, placebo‐controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women

P. Witt-Enderby, F. D'Amico, M. Kotlarczyk, 2012, Journal of pineal research.

Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene

J. Cline, P. Witt-Enderby, W. Foster, 2012, Evidence-based complementary and alternative medicine : eCAM.

Melatonin receptors and their regulation: biochemical and structural mechanisms.

M. J. Jarzynka, M. Melan, P. Witt-Enderby, 2003, Life sciences.

The Impact of Hormonal Contraceptives on Breast Cancer Pathology

S. Somiari, B. Deyarmin, Hai Hu, 2018, Hormones and Cancer.

Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer.

L. Zender, T. Kronenberger, P. Witt-Enderby, 2022, Journal of medicinal chemistry.

The Effect of Melatonin Upon Postacute Withdrawal Among Males in a Residential Treatment Program (M-PAWS): A Randomized, Double-blind, Placebo-controlled Trial

David A. Johnson, P. Witt-Enderby, V. Giannetti, 2018, Journal of addiction medicine.

Prevention and Treatment of Breast Cancer Using Melatonin

P. Witt-Enderby, V. Davis, B. Dodda, 2011 .

Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor.

M. Melan, P. Witt-Enderby, R. S. MacKenzie, 2000, Cell motility and the cytoskeleton.

Melatonin receptors as potential targets for drug discovery

P. Witt-Enderby, P.-K. Li, P. Witt‐Enderby, 2000 .

Drug conjugates—an emerging approach to treat breast cancer

R. Leak, P. Witt-Enderby, R. Stratford, 2018, Pharmacology research & perspectives.

N1E-115 mouse neuroblastoma cells express MT1 melatonin receptors and produce neurites in response to melatonin.

M. Melan, P. Witt-Enderby, S. L. Bordt, 2001, Biochimica et biophysica acta.

Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor.

M. Dubocovich, P. Witt-Enderby, M. Masana, 1998 .

Melatonin in Bone Health

P. Witt-Enderby, W. Clafshenkel, M. Kotlarczyk, 2011 .

MT1 melatonin receptor internalization underlies melatonin‐induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation

R. Jockers, M. Melan, P. Witt-Enderby, 2008, Journal of pineal research.

Could the Fountain of Youth Be All in Your Bones?

P. Witt-Enderby, P. Witt‐Enderby, 2013, The Journal of oral implantology.

Modulation of melatonin receptors and G‐protein function by microtubules

R. Jockers, M. J. Jarzynka, Deepshikha K Passey, 2006, Journal of pineal research.

Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer

J. Cline, P. Witt-Enderby, J. Latimer, 2019, Front. Oncol..

Novel Melatonin, Estrogen, and Progesterone Hormone Therapy Demonstrates Anti-Cancer Actions in MCF-7 and MDA-MB-231 Breast Cancer Cells

P. Witt-Enderby, M. Hasan, E. Browne, 2020, Breast cancer : basic and clinical research.

Pharmacy Students’ Evaluation of Pharmaceutical Advertisements: Research Evidence from a 5th year classroom

E. Toth, P. Witt‐Enderby, 2013 .

Development of a neuroscience-oriented "methods" course for graduate students of pharmacology and toxicology.

C. Anderson, David A. Johnson, P. Witt-Enderby, 2006, CBE life sciences education.

Melatonin Patterns and Levels During the Human Menstrual Cycle and After Menopause

S. Crawford, G. Greendale, Mei-hua Huang, 2020, Journal of the Endocrine Society.

Pharmacist and Student Knowledge and Perceptions of Herbal Supplements and Natural Products

James B. Schreiber, J. R. Covvey, P. Witt‐Enderby, 2023, Pharmacy.

Synthesis, NMR conformational analysis and pharmacological evaluation of 7,7a,13,14-tetrahydro-6H-cyclobuta[b]pyrimido[1,2-a:3,4-a']diindole analogues as melatonin receptor ligands.

P. Witt-Enderby, D. Zlotos, M. Attia, 2007, Organic & biomolecular chemistry.

Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner.

M. Melan, P. Witt-Enderby, M. P. Jones, 2000, Cancer letters.

Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal.

M. Dubocovich, P. Witt-Enderby, M. Masana, 2003, Biochemical pharmacology.

An Early Development Budget Impact Model for the Use of Melatonin in the Treatment and Prevention of Osteoporosi

Rahul Khairnar, C. Bondi, K. Kamal, 2015 .

Melatonin receptors and ligands.

P. Witt-Enderby, P. Li, P K Li, 2000, Vitamins and hormones.

Complementary and Alternative Medicine: Why hasn't the Science Kept Up with the Demand?

P. Witt-Enderby, H. Lassila, J. Balk, 2014 .

Regulation of airway muscarinic cholinergic receptor subtypes by chronic anticholinergic treatment.

P. Witt-Enderby, J. Palmer, H. Yamamura, 1995, Molecular pharmacology.

C‐terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization processes

P. Witt-Enderby, Wendy R Adams, Shalini Sethi, 2008, Journal of pineal research.

Synthesis and pharmacological analysis of high affinity melatonin receptor ligands.

P. Witt-Enderby, G. Chu, Marla Jones, 2002, Chemical & pharmaceutical bulletin.

The development of a charged melatonin receptor ligand

P. Witt-Enderby, Pui-Kai Li, G. Chu, 1997 .

Synthesis and receptor binding studies of quinolinic derivatives as melatonin receptor ligands

P. Witt-Enderby, Pui-Kai Li, G. Chu, 1997 .

R. Jockers, M. Melan, Paul F. Ignatius, 2008, Journal of pineal research.

M. Dubocovich, M. Masana, P. Witt‐Enderby, 1998 .

N1-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors

R. Jockers, P. Witt-Enderby, Mirna S. Sadek, 2014 .

Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands.

P. Witt-Enderby, M. Attia, M. I. Attia, 2008, Bioorganic & medicinal chemistry.