P. Guhathakurta

发表

Early-phase drug discovery of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia type 5

B. Svensson, T. Hays, A. L. Carter, 2023, The Journal of biological chemistry.

Identification of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia

B. Svensson, T. Hays, A. L. Carter, 2022, bioRxiv.

Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen

David D. Thomas, Andrew R. Thompson, Brett A. Colson, 2021, The Journal of biological chemistry.

High-throughput screen using fluorescence lifetime detects compounds that modulate myosin-binding protein C interactions with actin

David D. Thomas, Andrew R. Thompson, Brett A. Colson, 2021, bioRxiv.

Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin

David D. Thomas, B. Svensson, T. Hays, 2020, The Journal of biological chemistry.

Drug discovery for heart failure targeting myosin-binding protein C

Andrew R. Thompson, Brett A. Colson, Victoria C. Lepak, 2023, bioRxiv.

A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure.

David D. Thomas, E. Próchniewicz, John A. Rohde, 2017, Biophysical journal.

Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain

David D. Thomas, E. Próchniewicz, Piyali Guhathakurta, 2015, Proceedings of the National Academy of Sciences.

Allosteric communication in Dictyostelium myosin II

Joseph M. Muretta, M. Titus, David D. Thomas, 2012, Journal of Muscle Research and Cell Motility.

High-throughput screen, using time-resolved FRET, yields actin-binding compounds that modulate actin–myosin structure and function

David D. Thomas, Benjamin D Grant, E. Próchniewicz, 2018, The Journal of Biological Chemistry.

Actin-binding compounds, previously discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle

David D. Thomas, E. Próchniewicz, L. Phung, 2020, The Journal of Biological Chemistry.

Actin-Myosin Interaction: Structure, Function and Drug Discovery

David D. Thomas, E. Próchniewicz, Piyali Guhathakurta, 2018, International journal of molecular sciences.

Enhancing interaction of actin and actin-binding domain 1 of dystrophin with modulators: Toward improved gene therapy for Duchenne muscular dystrophy

Joseph M. Muretta, J. Ervasti, Andrew R. Thompson, 2022, The Journal of biological chemistry.

Journal Pre-proof Enhancing interaction of actin and actin-binding domain 1 of dystrophin with modulators: toward improved gene therapy for Duchenne muscular dystrophy

Joseph M. Muretta, David D. Thomas, Andrew R. Thompson, 2022 .

Actin-binding compounds, discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle

David D. Thomas, E. Próchniewicz, L. Phung, 2020, bioRxiv.

HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin

Y. Blat, D. Harden, D. Connors, 2023, SLAS discovery : advancing life sciences R & D.

The structural dynamics of actin during active interaction with myosin depends on the isoform of the essential light chain.

David D. Thomas, E. Próchniewicz, Piyali Guhathakurta, 2013, Biochemistry.

A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure.

David D. Thomas, E. Próchniewicz, John A. Rohde, 2017, Biophysical journal.