Karen N Allen

发表

Thermodynamic analysis shows conformational coupling and dynamics confer substrate specificity in fructose-1,6-bisphosphate aldolase.

Karen N. Allen, J. Stopa, D. Tolan, 2007, Biochemistry.

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.

Marco Galardini, George Kritikos, Ilan Wapinski, 2017, Cell systems.

Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.

P. T. Bremer, Karen N. Allen, K. Janda, 2017, Journal of the American Chemical Society.

Caught in the Act : The Structure of Phosphorylated â-Phosphoglucomutase from Lactococcus lactis

Guofeng Zhang, Karen N. Allen, D. Dunaway-Mariano, 2002 .

Crystallization and preliminary X-ray diffraction studies of beta-phosphoglucomutase from Lactococcus lactus.

Karen N. Allen, D. Dunaway-Mariano, S. Lahiri, 2002, Acta crystallographica. Section D, Biological crystallography.

The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex.

Karen N. Allen, P. Babbitt, G. L. Kenyon, 2002, Biochemistry.

Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes.

Karen N. Allen, L. Aravind, A. Burroughs, 2006, Journal of molecular biology.

Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide.

Karen N. Allen, B. Imperiali, E. Peisach, 2004, Angewandte Chemie.

Bioinformatic Analysis of the Flavin-Dependent Amine Oxidase Superfamily: Adaptations for Substrate Specificity and Catalytic Diversity.

Karen N. Allen, M. Tararina, Karen N Allen, 2020, Journal of molecular biology.

The surprising structural and mechanistic dichotomy of membrane-associated phosphoglycosyl transferases.

Karen N. Allen, B. Imperiali, K. O'Toole, 2021, Biochemical Society transactions.

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action.

Karen N. Allen, K. Janda, M. Hixon, 2011, Chemical communications.

A Catch and Anchor Approach to Combat both Toxicity and Longevity of Botulinum Toxin A.

Seth M. Cohen, K. Janda, Eric A. Johnson, 2020, Journal of medicinal chemistry.

Panoramic view of a superfamily of phosphatases through substrate profiling

Hua Huang, Nawar F Al-Obaidi, Steven C Almo, 2015, Proceedings of the National Academy of Sciences.

Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage.

Karen N. Allen, D. Dunaway-Mariano, S. Lahiri, 2006, Bioorganic chemistry.

Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis.

Karen N. Allen, D. Dunaway-Mariano, Liangbing Wang, 2005, Biochemistry.

Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily.

Karen N. Allen, D. Dunaway-Mariano, M. Morais, 2004, Biochemistry.

Crystallization of Liganded Phosphatases in the HAD Superfamily.

K. O'Toole, C. Harvey, Karen N Allen, 2018, Methods in enzymology.

Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-associated Protein 1 (KEAP1) and Nuclear Factor, Erythroid 2 Like 2 (Nrf2).

Karen N. Allen, Amanda E. Wakefield, S. Vajda, 2019, Biochemistry.

Structure of human brain fructose 1,6‐(bis)phosphate aldolase: Linking isozyme structure with function

Karen N. Allen, D. Zimmer, Karen N Allen, 2004, Protein science : a publication of the Protein Society.

Spatial Clustering of Isozyme-specific Residues Reveals Unlikely Determinants of Isozyme Specificity in Fructose-1,6-bisphosphate Aldolase*

Tanya Z Berardini, T. Berardini, Karen N Allen, 2003, The Journal of Biological Chemistry.

Monotopic Membrane Proteins Join the Fold.

Karen N. Allen, B. Imperiali, Leah C Ray, 2019, Trends in biochemical sciences.

Engineering encodable lanthanide-binding tags into loop regions of proteins.

Karen N. Allen, H. Schwalbe, B. Imperiali, 2011, Journal of the American Chemical Society.

Enzyme Promiscuity: Engine of Evolutionary Innovation*

Karen N. Allen, D. Dunaway-Mariano, Chetanya Pandya, 2014, The Journal of Biological Chemistry.

Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase.

S. Almo, D. Dunaway-Mariano, Y. Patskovsky, 2011, Biochemistry.

Markers of fitness in a successful enzyme superfamily.

Karen N. Allen, D. Dunaway-Mariano, Karen N Allen, 2009, Current opinion in structural biology.

X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily.

J. Selengut, D. Dunaway-Mariano, E. Peisach, 2004, Biochemistry.

Phosphoryl group transfer: evolution of a catalytic scaffold.

Karen N. Allen, D. Dunaway-Mariano, Karen N Allen, 2004, Trends in biochemical sciences.

Analysis of the substrate specificity loop of the HAD superfamily cap domain.

Karen N. Allen, D. Dunaway-Mariano, S. Lahiri, 2004, Biochemistry.

Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease.

Karen N. Allen, K. Janda, N. Silvaggi, 2010, Organic letters.

Expanding the viewpoint: Leveraging sequence information in enzymology.

Karen N. Allen, H. Knox, Karen N Allen, 2023, Current opinion in chemical biology.

Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.

Karen N. Allen, S. Tzipori, N. Silvaggi, 2008, Biochemistry.

Ligand deconstruction: Why some fragment binding positions are conserved and others are not

Dima Kozakov, Sandor Vajda, David R Hall, 2015, Proceedings of the National Academy of Sciences.

Tailoring Encodable Lanthanide‐Binding Tags as MRI Contrast Agents

Karen N. Allen, Langdon J. Martin, B. Imperiali, 2012, Chembiochem : a European journal of chemical biology.

Catalytic Mechanism of the Hotdog‐Fold Thioesterase PA1618 Revealed by X‐ray Structure Determination of a Substrate‐Bound Oxygen Ester Analogue Complex

Karen N. Allen, D. Dunaway-Mariano, J. Latham, 2017, Chembiochem : a European journal of chemical biology.

Co‐evolution of HAD phosphatase and hotdog‐fold thioesterase domain function in the menaquinone‐pathway fusion proteins BF1314 and PG1653

Karen N. Allen, F. Song, D. Dunaway-Mariano, 2013, FEBS letters.

X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture.

Karen N. Allen, B. Imperiali, E. Peisach, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The Pentacovalent Phosphorus Intermediate of a Phosphoryl Transfer Reaction

Karen N. Allen, D. Dunaway-Mariano, S. Lahiri, 2003, Science.

Consequences of domain insertion on sequence-structure divergence in a superfold

Shoshana D. Brown, Karen N. Allen, A. Sali, 2013, Proceedings of the National Academy of Sciences.

The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state

D. Dunaway-Mariano, Zhibing Lu, Karen N Allen, 2008, Proceedings of the National Academy of Sciences.

Exploring the structural origins of cryptic sites on proteins

Dima Kozakov, Dmitri Beglov, Sandor Vajda, 2018, Proceedings of the National Academy of Sciences.

Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A

Karen N. Allen, S. Tzipori, Eric A. Johnson, 2017, Toxicon : official journal of the International Society on Toxinology.

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.

Kim D Janda, Nicholas R Silvaggi, Karen N. Allen, 2013, Bioorganic & medicinal chemistry.

Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility.

Kim D Janda, Saul Tzipori, Nicholas R Silvaggi, 2007, Chemistry & biology.

Lanthanide-Binding Tags for 3D X-Ray Imaging of Proteins in Cells at Nanoscale Resolution.

Karen N. Allen, M. Ge, B. Imperiali, 2020, Journal of the American Chemical Society.

Structural Analysis of Binding Determinants of Salmonella typhimurium Trehalose-6-phosphate Phosphatase using Ground-State Complexes.

Karen N. Allen, D. Dunaway-Mariano, P. Mariano, 2020, Biochemistry.

Binding energy and catalysis by D-xylose isomerase: kinetic, product, and X-ray crystallographic analysis of enzyme-catalyzed isomerization of (R)-glyceraldehyde.

Karen N. Allen, N. Silvaggi, J. Richard, 2011, Biochemistry.

Lanthanide-tagged proteins--an illuminating partnership.

Karen N. Allen, B. Imperiali, Karen N Allen, 2010, Current opinion in chemical biology.

Double-lanthanide-binding tags for macromolecular crystallographic structure determination.

Karen N. Allen, Langdon J. Martin, H. Schwalbe, 2007, Journal of the American Chemical Society.

Double-lanthanide-binding tags: design, photophysical properties, and NMR applications.

Karen N. Allen, Langdon J. Martin, H. Schwalbe, 2007, Journal of the American Chemical Society.

Membrane association of monotopic phosphoglycosyl transferase underpins function

Karen N. Allen, B. Imperiali, V. Lukose, 2018, Nature Chemical Biology.

Conservation and Covariance in Small Bacterial Phosphoglycosyltransferases Identify the Functional Catalytic Core.

Karen N. Allen, S. Vajda, B. Imperiali, 2015, Biochemistry.

Glycoconjugate pathway connections revealed by sequence similarity network analysis of the monotopic phosphoglycosyl transferases

Karen N. Allen, B. Imperiali, K. O'Toole, 2021, Proceedings of the National Academy of Sciences.

Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces.

Karen N. Allen, B. Imperiali, Karen N Allen, 2019, Current opinion in structural biology.

A Central Region of NEMO is Required for IKKβ-Induced Conformational Change and for Signal Propagation.

Karen N. Allen, A. Whitty, L. Makowski, 2019, Biochemistry.

Catalytic scaffolds for phosphoryl group transfer.

D. Dunaway-Mariano, Karen N Allen, 2016, Current opinion in structural biology.

HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131.

Karen N. Allen, D. Dunaway-Mariano, Zhibing Lu, 2005, Biochemistry.

Structural Insights into the Substrate Range of a Bacterial Monoamine Oxidase.

Karen N. Allen, J. Galagan, M. Tararina, 2023, Biochemistry.

Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.

Karen N. Allen, A. Whitty, T. Gilmore, 2013, Biochemistry.

The X‐ray crystallographic structure and activity analysis of a Pseudomonas‐specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function

Liangbing Wang, Karen N. Allen, Ezra Peisach, 2007, Proteins.

The Enzyme Function Initiative.

Heidi J. Imker, Karen N. Allen, A. Sali, 2011, Biochemistry.

Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis.

Karen N. Allen, D. Dunaway-Mariano, E. Peisach, 2009, Biochemistry.

Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6-(Bis)phosphate intermediate.

Karen N. Allen, D. Dunaway-Mariano, Liangbing Wang, 2006, Biochemistry.

X-ray Crystallographic and Site-directed Mutagenesis Analysis of the Mechanism of Schiff-base Formation in Phosphonoacetaldehyde Hydrolase Catalysis*

Karen N. Allen, D. Dunaway-Mariano, M. Morais, 2004, Journal of Biological Chemistry.

Structure of the thermolabile mutant aldolase B, A149P: molecular basis of hereditary fructose intolerance.

Karen N. Allen, A. Malay, D. Tolan, 2005, Journal of molecular biology.

Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily.

Karen N. Allen, D. Dunaway-Mariano, L. Tremblay, 2006, Biochemistry.

Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis.

D. Dunaway-Mariano, Guofeng Zhang, A. Mazurkie, 2002, Biochemistry.

Structure‐guided approach for detecting large domain inserts in protein sequences as illustrated using the haloacid dehalogenase superfamily

Karen N. Allen, Yuhao Xia, D. Dunaway-Mariano, 2014, Proteins.

Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).

Henry H Nguyen, Karen N. Allen, D. Dunaway-Mariano, 2010, Biochemistry.

Chemical‐modification rescue assessed by mass spectrometry demonstrates that γ‐thia‐lysine yields the same activity as lysine in aldolase

Karen N. Allen, C. Costello, D. Tolan, 2002, Protein science : a publication of the Protein Society.

Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.

Megan C. Garland, R. Wu, D. Dunaway-Mariano, 2011, Biochemistry.

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.

Karen N. Allen, K. Janda, Lauren C. Smith, 2018, Biochemistry.

Conservation and Covariance in Small Bacterial Phosphoglycosyltransferases Identify the Functional Catalytic Core.

S. Vajda, B. Imperiali, D. Kozakov, 2015, Biochemistry.

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.

C. Gross, I. Wapinski, D. Rudner, 2017, Cell systems.

The Enzyme Function Initiative.

Heidi J. Imker, A. Sali, P. Babbitt, 2011, Biochemistry.

Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase.

D. Dunaway-Mariano, Guofeng Zhang, L. Tremblay, 2005, Journal of the American Chemical Society.

Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).

Karen N. Allen, D. Dunaway-Mariano, Liangbing Wang, 2008, Chemistry & biology.

Structure-Guided Insight into the Specificity and Mechanism of a Parasitic Nucleoside Hydrolase.

Karen N. Allen, B. Stockman, A. Schoenfeld, 2022, Biochemistry.

A structural element that facilitates proton-coupled electron transfer in oxalate decarboxylase.

Karen N. Allen, W. Cleland, N. Richards, 2012, Biochemistry.

Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis.

D. Dunaway-Mariano, S. Lahiri, Guofeng Zhang, 2002, Biochemistry.

Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase.

C. Unkefer, J. Bacik, D. Dunaway-Mariano, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2.

K. Janda, B. Palfey, M. Tararina, 2021, Biochemistry.

Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.

Karen N. Allen, Aaron B. Beeler, A. Whitty, 2021, Journal of the American Chemical Society.

Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase.

S. Almo, D. Dunaway-Mariano, Y. Patskovsky, 2011, Biochemistry.