Siegfried Labeit

发表

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2

Christian C Witt, Stephanie H Witt, Stefanie Lerche, 2007, The EMBO journal.

Cardiac titin: an adjustable multi‐functional spring

Siegfried Labeit, Henk Granzier, H. Granzier, 2002, The Journal of physiology.

PKC Phosphorylation of Titin’s PEVK Element: A Novel and Conserved Pathway for Modulating Myocardial Stiffness

Siegfried Labeit, Henk Granzier, Brian R. Anderson, 2009, Circulation research.

Conditional Expression of Mutant M-line Titins Results in Cardiomyopathy with Altered Sarcomere Structure*

Christian C Witt, Siegfried Labeit, Joachim Herz, 2003, The Journal of Biological Chemistry.

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

Markus Reischl, Rüdiger Rudolf, Siegfried Labeit, 2014, Autophagy.

Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy

John Atherton, Siegfried Labeit, Henk Granzier, 2006, Journal of Molecular Medicine.

Nebulin regulates thin filament length, contractility, and Z‐disk structure in vivo

Yiming Wu, Dietmar Labeit, Siegfried Labeit, 2006, The EMBO journal.

Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy

Yiming Wu, Christian C. Witt, Siegfried Labeit, 2004, Circulation.

Association of the chaperone alphaB-crystallin with titin in heart muscle.

Belinda Bullard, Dietmar Labeit, Siegfried Labeit, 2004, The Journal of biological chemistry.

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.

Yiming Wu, Christian C Witt, Stephanie H Witt, 2004, Journal of molecular biology.

The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

Christian C Witt, Dietmar Labeit, Siegfried Labeit, 2003, Journal of molecular biology.

I-Band Titin in Cardiac Muscle Is a Three-Element Molecular Spring and Is Critical for Maintaining Thin Filament Structure

Wolfgang A. Linke, Siegfried Labeit, Mathias Gautel, 1999, The Journal of cell biology.

Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments.

Siegfried Labeit, Henk Granzier, H. Granzier, 2002, Journal of structural biology.

Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins.

Dietmar Labeit, Siegfried Labeit, Henk Granzier, 2006, Journal of molecular biology.

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.

Yiming Wu, Dietmar Labeit, Siegfried Labeit, 2003, Advances in experimental medicine and biology.

Changes in Titin Isoform Expression in Pacing-Induced Cardiac Failure Give Rise to Increased Passive Muscle Stiffness

Yiming Wu, Christian C Witt, Siegfried Labeit, 2002, Circulation.

Titin-Actin Interaction: PEVK-Actin-Based Viscosity in a Large Animal

Siegfried Labeit, H. Granzier, S. Labeit, 2011, Journal of biomedicine & biotechnology.

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.

Christian C Witt, Stephanie H Witt, Siegfried Labeit, 2005, Journal of molecular biology.

Calcium-dependent molecular spring elements in the giant protein titin

Yiming Wu, Dietmar Labeit, Siegfried Labeit, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cardiac titin: structure, functions and role in disease.

Yiming Wu, Siegfried Labeit, Henk Granzier, 2007, Clinica chimica acta; international journal of clinical chemistry.

Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase

Klaus Schulten, Dmitri I Svergun, Olga Mayans, 2012, Proceedings of the National Academy of Sciences.

Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

Siegfried Labeit, B. Kolmerer, S. Labeit, 1995, Science.

Tuning passive mechanics through differential splicing of titin during skeletal muscle development.

Siegfried Labeit, Henk Granzier, C. Ottenheijm, 2009, Biophysical journal.

Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease.

Siegfried Labeit, Henk Granzier, Ludwig Thierfelder, 2009, Journal of molecular and cellular cardiology.

Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy

John Atherton, Siegfried Labeit, Henk Granzier, 2002, Nature Genetics.

The Sarcomeric Protein Nebulin: Another Multifunctional Giant in Charge of Muscle Strength Optimization

Siegfried Labeit, Henk Granzier, C. Ottenheijm, 2012, Front. Physio..

Molecular Mechanics of Cardiac Titin's PEVK and N2B Spring Elements*

Dietmar Labeit, Siegfried Labeit, Henk Granzier, 2002, The Journal of Biological Chemistry.

Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance.

Yiming Wu, Siegfried Labeit, Henk Granzier, 2007, Journal of molecular and cellular cardiology.

The NH2 Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity

Siegfried Labeit, Henk Granzier, C. Gregorio, 1998, The Journal of cell biology.

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin.

Leena Peltonen, Siegfried Labeit, Bjarne Udd, 2002, American journal of human genetics.

The giant protein titin: a major player in myocardial mechanics, signaling, and disease.

Siegfried Labeit, H. Granzier, S. Labeit, 2004, Circulation research.

The complete mouse nebulin gene sequence and the identification of cardiac nebulin.

Christian C Witt, Siegfried Labeit, C. Gregorio, 2003, Journal of molecular biology.

Degeneration of Neuromuscular Junction in Age and Dystrophy

Rüdiger Rudolf, Siegfried Labeit, M. Deschenes, 2014, Front. Aging Neurosci..

Molecular determinants for the recruitment of the ubiquitin‐ligase MuRF‐1 onto M‐line titin

Olga Mayans, Dietmar Labeit, Siegfried Labeit, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

Dietmar Labeit, Siegfried Labeit, M. Bang, 2001 .

Titin Extensibility In Situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments

Siegfried Labeit, Henk Granzier, H. Granzier, 1998, The Journal of cell biology.

Dimerization of the cardiac ankyrin protein CARP: Implications for MARP titin-based signaling

Christian C. Witt, Stephanie H. Witt, Dietmar Labeit, 2006, Journal of Muscle Research & Cell Motility.

Association of the Chaperone αB-crystallin with Titin in Heart Muscle*

Wolfgang A. Linke, Belinda Bullard, Mark C. Leake, 2004, Journal of Biological Chemistry.

Cardiac Hypertrophy and Reduced Contractility in Hearts Deficient in the Titin Kinase Region

Yiming Wu, Siegfried Labeit, Henk Granzier, 2007, Circulation.

Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium

Yiming Wu, Siegfried Labeit, Henk Granzier, 2004, Circulation research.

Single Molecule Force Spectroscopy of the Cardiac Titin N2B Element

Siegfried Labeit, Henk Granzier, H. Granzier, 2009, Journal of Biological Chemistry.

Titin isoform-dependent effect of calcium on passive myocardial tension.

Dietmar Labeit, Siegfried Labeit, H. Fujita, 2004, American journal of physiology. Heart and circulatory physiology.