Jessica L. Childs‐Disney

发表

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.

Jonathan L Chen, Jessica L. Childs-Disney, M. Disney, 2018, Chemical reviews.

A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence.

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2018, Chem.

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

Jessica L. Childs-Disney, M. Disney, Valerie Cavett, 2022, Proceedings of the National Academy of Sciences.

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin.

Jessica L. Childs-Disney, M. Disney, A. Adibekian, 2019, Journal of the American Chemical Society.

Fragment-Based Approaches to Identify RNA Binders.

M. Disney, A. Taghavi, B. Suresh, 2023, Journal of medicinal chemistry.

Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.

Jessica L. Childs-Disney, M. Disney, Toru Tanaka, 2021, Journal of the American Chemical Society.

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models

Eric T. Wang, Jonathan L Chen, Jessica L. Childs-Disney, 2021, Science Translational Medicine.

How We Think about Targeting RNA with Small Molecules.

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2020, Journal of medicinal chemistry.

Targeting RNA structures with small molecules

Jessica L. Childs-Disney, M. Disney, R. Batey, 2022, Nature Reviews Drug Discovery.

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2017, ACS central science.

Improvement of RNA secondary structure prediction using RNase H cleavage and randomized oligonucleotides

Jessica L. Childs-Disney, Andrew D. Kauffmann, Ryan J. Campagna, 2009, Nucleic acids research.

Using Selection to Identify and Chemical Microarray to Study the RNA Internal Loops Recognized by 6′‐N‐Acylated Kanamycin A

Jessica L. Childs-Disney, M. Disney, Jessica L. Childs‐Disney, 2007, Chembiochem : a European journal of chemical biology.

Drugging the RNA World.

Jessica L. Childs-Disney, M. Disney, Brendan G. Dwyer, 2018, Cold Spring Harbor perspectives in biology.

Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2018, Cell chemical biology.

Methods to enable the design of bioactive small molecules targeting RNA.

Jessica L. Childs-Disney, Ilyas Yildirim, M. Disney, 2014, Organic & biomolecular chemistry.

Drugging the RNAWorld

Jessica L. Childs-Disney, M. Disney, Brendan G. Dwyer, 2018 .

The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.

Jessica L. Childs-Disney, L. Petrucelli, Ilyas Yildirim, 2019, Cell chemical biology.

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

Matthew D Disney, Donald G Phinney, Jessica L. Childs-Disney, 2017, Journal of the American Chemical Society.

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs.

Matthew D Disney, Mohammad Fallahi, Mark Southern, 2016, ACS chemical biology.

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity.

George C Schatz, Matthew D Disney, HaJeung Park, 2014, ACS chemical biology.

Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.

Jessica L. Childs-Disney, M. Disney, C. Thornton, 2012, ACS chemical biology.

Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.

Jessica L. Childs-Disney, M. Disney, Jessica L. Childs‐Disney, 2016, Annual review of pharmacology and toxicology.

Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity.

Jessica L. Childs-Disney, M. Disney, Jared T. Baisden, 2021, Current opinion in chemical biology.

Small molecule recognition of disease-relevant RNA structures.

Jessica L. Childs-Disney, M. Disney, Toru Tanaka, 2020, Chemical Society reviews.

The Role of Flexibility in the Rational Design of Modularly Assembled Ligands Targeting the RNAs that Cause the Myotonic Dystrophies

Jessica L. Childs-Disney, M. Disney, A. Pushechnikov, 2010, Chembiochem : a European journal of chemical biology.

Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy.

Jessica L. Childs-Disney, M. Disney, K. Sobczak, 2009, Journal of the American Chemical Society.

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

Jessica L. Childs-Disney, M. Disney, K. Sobczak, 2009, Journal of the American Chemical Society.

Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies

Jessica L. Childs-Disney, Ilyas Yildirim, M. Disney, 2023, Nucleic acids research.

Gini coefficients as a single value metric to define chemical probe selectivity.

Jessica L. Childs-Disney, M. Disney, Alicia J. Angelbello, 2020, ACS chemical biology.

Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods.

Jessica L. Childs-Disney, M. Disney, D. Phinney, 2017, Methods in molecular biology.

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

Eric T. Wang, Jessica L. Childs-Disney, E. Wang, 2020, Proceedings of the National Academy of Sciences.

Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.

Eric T. Wang, Matthew D Disney, David Housman, 2012, Journal of the American Chemical Society.

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

Walter N. Moss, Jessica L. Childs-Disney, M. Disney, 2020, Proceedings of the National Academy of Sciences.

RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression

Jonathan L Chen, Walter N. Moss, Jessica L. Childs-Disney, 2019, PloS one.

Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1.

Jessica L. Childs-Disney, M. Disney, R. Parkesh, 2012, ACS chemical biology.

Analysis of secondary structural elements in human microRNA hairpin precursors

Dan Wang, Brent M. Znosko, Steven M. Gallo, 2016, BMC Bioinformatics.

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

Jonathan L Chen, Walter N. Moss, Jessica L. Childs-Disney, 2019, bioRxiv.

Progress toward the development of the small molecule equivalent of small interfering RNA.

Jessica L. Childs-Disney, M. Disney, R. I. Benhamou, 2020, Current opinion in chemical biology.

Progress towards the development of the small molecule equivalent of small interfering RNA (siRNA)

Jessica L. Childs-Disney, M. Disney, R. I. Benhamou, 2020 .

Induction and Reversal of Myotonic Dystrophy Type 1 Pre-mRNA Splicing Defects by Small Molecules

Juan J. Marugan, Noel Southall, Wei Zheng, 2013, Nature Communications.

Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners.

Matthew D Disney, Jessica L. Childs-Disney, Jessica L Childs-Disney, 2008, Journal of the American Chemical Society.

Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands.

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2020, Journal of the American Chemical Society.

Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models.

Hafeez S Haniff, M. Disney, Yuquan Tong, 2021, ACS chemical biology.

Programming inactive RNA-binding small molecules into bioactive degraders

Hafeez S Haniff, F. Glorius, M. Disney, 2023, Nature.

Design of small molecules targeting RNA structure from sequence.

Matthew D Disney, Andrei Ursu, Walter N. Moss, 2020, Chemical Society reviews.

A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome.

Matthew D Disney, Jessica L. Childs-Disney, Jessica L Childs-Disney, 2012, ACS chemical biology.

DNA‐Encoded Libraries and Their Application to RNA

M. Disney, Xueyi Yang, Jessica L. Childs‐Disney, 2023, Israel Journal of Chemistry.

Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts.

Matthew D Disney, Raman Parkesh, Krzysztof Sobczak, 2012, ACS chemical biology.

A small molecule microarray platform to select RNA internal loop-ligand interactions.

Matthew D Disney, Jessica L. Childs-Disney, Olga Aminova, 2007, ACS chemical biology.

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.

Jonathan L Chen, Jessica L. Childs-Disney, G. Rumbaugh, 2020, Journal of the American Chemical Society.

Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma.

Jessica L. Childs-Disney, M. Disney, Jessica L. Childs‐Disney, 2016, ACS chemical biology.

A meditation on accelerating the development of small molecule medicines targeting RNA

Jessica L. Childs-Disney, M. Disney, Xueyi Yang, 2022, Expert opinion on drug discovery.

Targeting the r(CGG) Repeats That Cause FXTAS with Modularly Assembled Small Molecules and Oligonucleotides

Jessica L. Childs-Disney, M. Disney, T. Tran, 2014, ACS chemical biology.

Computational Tools for Design of Selective Small Molecules Targeting RNA: From Small Molecule Microarrays to Chemical Similarity Searching

Jessica L. Childs-Disney, M. Disney, Matthew G. Costales, 2017 .

A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections.

M. Disney, Jessica L. Childs‐Disney, 2007, RNA.

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

M. Disney, D. Phinney, C. L. Haga, 2017, Journal of the American Chemical Society.