W. Pappano

发表

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Jun Guo, Kenneth M Comess, Haizhong Zhu, 2017, Nature chemical biology.

Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling

Ken W. Y. Cho, I. Blitz, W. N. Pappano, 2001, Nature.

erratum: Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling

Ken W. Y. Cho, I. Blitz, W. N. Pappano, 2001, Nature.

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.

Mikkel A. Algire, N. Soni, C. Arrowsmith, 2015, ACS medicinal chemistry letters.

Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.

C. Tse, A. Petros, N. Soni, 2014, ACS medicinal chemistry letters.

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

Xin Lu, J. Leverson, W. N. Pappano, 2015, Molecular Cancer Therapeutics.

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

Kedar S Vaidya, L. Naumovski, P. Ansell, 2016, BMC Cancer.

Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases

W. N. Pappano, D. Greenspan, M. Davies, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

C. Tse, M. Michaelides, W. N. Pappano, 2015, PloS one.

Multiple Bone Morphogenetic Protein 1-related Mammalian Metalloproteinases Process Pro-lysyl Oxidase at the Correct Physiological Site and Control Lysyl Oxidase Activation in Mouse Embryo Fibroblast Cultures

W. N. Pappano, D. Greenspan, I. Scott, 2001, The Journal of Biological Chemistry.

Biosynthetic Processing of the Pro-α1(V)2Pro-α2(V) Collagen Heterotrimer by Bone Morphogenetic Protein-1 and Furin-like Proprotein Convertases*

Y. Imamura, W. N. Pappano, D. Greenspan, 2002, The Journal of Biological Chemistry.

Proteinases of the Bone Morphogenetic Protein-1 Family Convert Procollagen VII to Mature Anchoring Fibril Collagen*

R. Timpl, Takako Sasaki, R. Burgeson, 2002, The Journal of Biological Chemistry.

Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response

Min-Sung Kim, P. Beachy, D. Leahy, 2010, Proceedings of the National Academy of Sciences.

Mammalian Tolloid Metalloproteinase, and Not Matrix Metalloprotease 2 or Membrane Type 1 Metalloprotease, Processes Laminin-5 in Keratinocytes and Skin*

D. Veitch, W. N. Pappano, K. McGowan, 2003, The Journal of Biological Chemistry.

Bone Morphogenetic Protein-1 Processes Probiglycan*

P. Roughley, Y. Imamura, W. N. Pappano, 2000, The Journal of Biological Chemistry.

Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.

Ken W. Y. Cho, I. Blitz, Y. Imamura, 1999, Developmental biology.

Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases.

Y. Imamura, D. Greenspan, B. Steiglitz, 2002, Journal of Biological Chemistry.

Procollagen C Proteinase Enhancer 1 Genes Are Important Determinants of the Mechanical Properties and Geometry of Bone and the Ultrastructure of Connective Tissues

S. Goldstein, W. N. Pappano, D. Greenspan, 2006, Molecular and Cellular Biology.

Use of Bmp1/Tll1 Doubly Homozygous Null Mice and Proteomics To Identify and Validate In Vivo Substrates of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteinases

W. N. Pappano, D. Keene, D. Greenspan, 2003, Molecular and Cellular Biology.

Regulation of Pulsatile Luteinizing Hormone Secretion by Insulin in the Diabetic Male Lamb1

W. N. Pappano, H. Tsukamura, K. Maeda, 2000, Biology of reproduction.

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

Kedar S Vaidya, L. Naumovski, P. Ansell, 2016, BMC Cancer.

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Mikkel A. Algire, K. Comess, Chaohong Sun, 2017, Nature chemical biology.

Spatiotemporal expression patterns of mammalian chordin during postgastrulation embryogenesis and in postnatal brain

W. N. Pappano, D. Greenspan, I. Scott, 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

Cell-surface Heparan Sulfate Proteoglycans Potentiate Chordin Antagonism of Bone Morphogenetic Protein Signaling and Are Necessary for Cellular Uptake of Chordin*

W. N. Pappano, B. L. Allen, D. Greenspan, 2004, Journal of Biological Chemistry.

Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efﬁ cacy in Combination with Immune Checkpoint Blockade

Salem, P. Ellis, J. Leverson, 2020 .

Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning

N. Shubin, W. N. Pappano, R. Dahn, 2007, Nature.

Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.

Scott A. Erickson, S. Davidsen, K. Swinger, 2010, Bioorganic & medicinal chemistry letters.

Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation.

K. Glaser, L. Lam, C. Tse, 2017, Biochemical and biophysical research communications.

Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells

C. Tse, W. N. Pappano, Qian Zhang, 2014, BMC Cancer.

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605

S. Davidsen, Eric F. Johnson, N. Soni, 2009, BMC Cancer.

A “Prozone-Like” Effect Influences the Efficacy of the Monoclonal Antibody ABT-700 against the Hepatocyte Growth Factor Receptor

Kedar S Vaidya, Mark G. Anderson, W. N. Pappano, 2017, Pharmacology.

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

Xin Lu, J. Leverson, S. Elmore, 2015, Molecular Cancer Therapeutics.

The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.

Ryan A McClure, K. Longenecker, Chaohong Sun, 2022, ACS chemical biology.

Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes.

W. Pappano, D. Greenspan, T. B. Shows, 1998, Genomics.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Mikkel A. Algire, Justin D Dietrich, A. Petros, 2017, Nature chemical biology.