Jessica A. Bush

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models

Eric T. Wang, Jonathan L Chen, Jessica L. Childs-Disney, 2021, Science Translational Medicine.

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD.

Jonathan L Chen, L. Petrucelli, Ilyas Yildirim, 2020, ACS chemical biology.

Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models.

Hafeez S Haniff, M. Disney, Yuquan Tong, 2021, ACS chemical biology.

Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion.

M. Disney, A. Taghavi, H. Aikawa, 2022, Journal of the American Chemical Society.

Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy

Eric T. Wang, M. Disney, A. Taghavi, 2023, ACS central science.