A. Look

发表

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.

E. Lander, T. Golub, C. Huard, 2002, Cancer cell.

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

F. Speleman, K. De Preter, B. Abraham, 2021, Cancers.

mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues

R. Balice-Gordon, C. Felix, G. Basso, 2011, British journal of haematology.

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

R. Young, T. Golub, W. Hahn, 2018, Nature Genetics.

Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State

R. Young, J. Joung, J. Maris, 2023, bioRxiv.

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

Rob Pieters, Christopher Winter, Giulio Draetta, 2007, The Journal of experimental medicine.

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

S. Armstrong, S. Korsmeyer, A. Ferrando, 2003, Blood.

Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors

A. Look, P. Houghton, T. Inaba, 2001, Molecular and Cellular Biology.

Activating mutations in ALK provide a therapeutic target in neuroblastoma

D. Gary Gilliland, Stefan Fröhling, Wendy B. London, 2008, Nature.

Molecular genetics of acute lymphoblastic leukemia.

S. Armstrong, A. Look, A. Thomas Look, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Gene expression profiling in T-cell acute lymphoblastic leukemia.

A. Ferrando, A. Look, A. Look, 2003, Seminars in hematology.

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.

J. Downing, L. Chin, F. Alt, 2011, Blood.

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

R. Young, A. Look, J. Maris, 2019, Nature Communications.

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.

M. Loh, L. Chin, A. Protopopov, 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The cytogenetics of childhood leukemia: clinical and biologic implications.

A. Look, A. Look, 1988, Pediatric clinics of North America.

Chromosome 1p and 11q deletions and outcome in neuroblastoma.

Hiroyuki Shimada, Cynthia Winter, John M Maris, 2005, The New England journal of medicine.

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

R. Young, J. Joung, J. Maris, 2023, The Journal of clinical investigation.

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL

A. Look, C. Novina, H. von Boehmer, 2011, The Journal of experimental medicine.

Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.

A. Ferrando, D. Neuberg, A. Look, 2004, Blood.

The requirement for cyclin D function in tumor maintenance.

A. Look, S. Signoretti, A. Christie, 2012, Cancer cell.

Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation.

A. Look, J. O'neil, F. Gounari, 2007, Blood.

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

A. Look, J. Testa, Rugang Zhang, 2012, Blood.

NUP98‐HOXA9‐transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis

J. Berman, C. Grabher, Elspeth M. Payne, 2011, British journal of haematology.

Anti‐leukaemic activity of the TYK2 selective inhibitor NDI‐031301 in T‐cell acute lymphoblastic leukaemia

A. Look, J. Greenwood, J. Etchin, 2017, British journal of haematology.

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

A. Look, D. Weinstock, K. Akahane, 2015, Leukemia.

Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing puma

A. Look, G. Zambetti, Jerry M. Adams, 2005, Cell.

Identification of structural aberrations in cancer by SNP array analysis

Stefan Heinrichs, A. Look, A Thomas Look, 2007, Genome Biology.

Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.

A. Ferrando, A. Look, K. Akashi, 2002, Cancer cell.

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy

A. Look, S. Morris, T. Webb, 2009, Expert review of anticancer therapy.

Cyclin C is a haploinsufficient tumour suppressor

Na Li, Iannis Aifantis, Jon C. Aster, 2014, Nature Cell Biology.

Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell.

A. Look, Amy McKee, C. Thiele, 2007, Cancer research.

Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

Timothy Harrison, Giulio Draetta, Hellen Kim, 2007, Chemistry & biology.

DNA Microarrays in the Diagnosis and Management of Acute Lymphoblastic Leukemia

Adolfo A. Ferrando, A. Ferrando, A. Thomas Look, 2004, International journal of hematology.

Clinical importance of near-diploid tumor stem lines in patients with osteosarcoma of an extremity.

A. Look, E. Douglass, W. Meyer, 1988, The New England journal of medicine.

The E2A-HLF Oncoprotein ActivatesGroucho-Related Genes and SuppressesRunx1

J. Downing, A. Look, N. Lenny, 2001, Molecular and Cellular Biology.

Zebrafish foxd3 is selectively required for neural crest specification, migration and survival.

Brigitte L. Arduini, A. Look, J. Kanki, 2006, Developmental biology.

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells by XPO1 inhibitors

A. Look, Shuning He, N. Prutsch, 2022, bioRxiv.

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

D. Neuberg, A. Look, M. Harris, 2011, The Journal of experimental medicine.

A leukemogenic twist for GATA1

A. Look, A. Look, 2002, Nature Genetics.

acute leukemias : dominance of-rearranged T-lineage and B-precursor MLL Gene expression signatures

S. Armstrong, S. Korsmeyer, A. Ferrando, 2003 .

Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.

L. Zon, A. Look, D. Traver, 2004, Blood.

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

K. Ross, A. Look, J. Aster, 2019, PLoS genetics.

p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis.

A. Look, D. Kelsell, S. Carbonneau, 2011, Developmental cell.

Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics*

P. Sorger, D. Sabatini, A. Look, 2012, The Journal of Biological Chemistry.

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

R. Young, A. Look, B. Li, 2017, Leukemia.

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

A. Look, D. DeAngelo, D. Weinstock, 2015, Leukemia.

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

T. Aittokallio, S. Mustjoki, T. Haferlach, 2022, bioRxiv.

Notch signaling: switching an oncogene to a tumor suppressor.

Iannis Aifantis, A. Look, I. Aifantis, 2014, Blood.

IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.

A. Ferrando, A. Look, S. Sallan, 2004, Blood.

Synthetic lethal targeting of TET2‐mutant haematopoietic stem and progenitor cells by XPO1 inhibitors

Shuning He, N. Prutsch, Y. Landesman, 2023, British journal of haematology.

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.

Richard S Larson, Jennifer O'Neil, Donna S Neuberg, 2010, Blood.

Discovery of a selective irreversible BMX inhibitor for prostate cancer.

N. Gray, Qingsong Liu, W. Hur, 2013, ACS chemical biology.

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification.

Richard A. Young, R. Young, A. Look, 2018, Cancer discovery.

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

B. Clurman, R. Sears, R. Pieters, 2007, The Journal of experimental medicine.

STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma

K. Stegmaier, Shuning He, N. Prutsch, 2024, Cell reports. Medicine.

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia

T. Aittokallio, S. Mustjoki, N. Prutsch, 2024, The Journal of clinical investigation.

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors

A. Look, J. D. de Rooi, R. Pieters, 2014, Haematologica.

The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells

A. Look, Shuning He, Zhaodong Li, 2018, Leukemia.