Alexander N. Phillipou

发表

Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.

P. Grandi, I. Wall, James M. Woolven, 2021, Journal of medicinal chemistry.

Development of an intracellular quantitative assay to measure compound binding kinetics.

Kris D. McCombe, Kristin M. Riching, Daniel A. Thomas, 2021, Cell chemical biology.

Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.

P. Bamborough, R. Prinjha, C. Chung, 2021, ACS medicinal chemistry letters.

Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.

P. Grandi, I. Wall, James M. Woolven, 2021, Journal of medicinal chemistry.

GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins.

P. Grandi, P. Bamborough, R. Prinjha, 2020, Journal of medicinal chemistry.

The Optimisation of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.

P. Bamborough, R. Prinjha, C. Chung, 2020, Journal of medicinal chemistry.

Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions

Aaron T. Cheng, D. J. Brierley, Antonia J Lewis, 2019, SLAS discovery : advancing life sciences R & D.

Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation.

Jonathan M. Lea, J. Liddle, P. Rowland, 2020, Journal of medicinal chemistry.

Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System

P. Rowland, P. Craggs, Bhumika Karamshi, 2021, SLAS discovery : advancing life sciences R & D.

Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit.

P. Grandi, I. Wall, R. Prinjha, 2021, Journal of medicinal chemistry.

Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.

P. Bamborough, R. Prinjha, P. Soden, 2023, ACS medicinal chemistry letters.