Alistair S Brown

发表

Structural, functional and evolutionary perspectives on effective re-engineering of non-ribosomal peptide synthetase assembly lines.

Alistair S Brown, Mark J Calcott, Jeremy G Owen, 2018, Natural product reports.

Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts

Alistair S Brown, Robert A. Keyzers, P. Northcote, 2020, mBio.

High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor

Alistair S Brown, D. Ackerley, M. Calcott, 2020, Molecules.

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

Alistair S Brown, R. Hancock, N. Tokuriki, 2020, mBio.

The indigoidine synthetase BpsA provides a colorimetric ATP assay that can be adapted to quantify the substrate preferences of other NRPS enzymes

Alistair S Brown, D. Ackerley, J. Owen, 2020, Biotechnology Letters.

Engineering the indigoidine-synthesising enzyme BpsA for diverse applications in biotechnology

Alistair S Brown, D. Ackerley, J. Owen, 2017 .

Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT

Alistair S Brown, E. Baker, D. Ackerley, 2021, Pharmaceutics.

A sensitive single-enzyme assay system using the non-ribosomal peptide synthetase BpsA for measurement of L-glutamine in biological samples

Alistair S Brown, D. Ackerley, K. Robins, 2017, Scientific Reports.

Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferases for Counter-Screening Antibiotic Candidates.

Alistair S Brown, D. Ackerley, J. Owen, 2020, ACS infectious diseases.

Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein.

Alistair S Brown, E. Baker, J. Johnston, 2014, Journal of structural biology.

Title: Mechanistic understanding enables the rational design of salicylanilide

Alistair S Brown, Williams, R. Hancock, 2020 .

Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein.

Alistair S Brown, E. Baker, J. Johnston, 2014, Journal of structural biology.