M. García-Moreno

发表

Fluorinated Chaperone-β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease.

K. Higaki, E. Nanba, J. M. Benito, 2017, Journal of medicinal chemistry.

Bicyclic Derivatives of L‐Idonojirimycin as Pharmacological Chaperones for Neuronopathic Forms of Gaucher Disease

F. Sánchez-Jiménez, C. Ortiz Mellet, J. G. García Fernández, 2013, Chembiochem : a European journal of chemical biology.

sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

K. Higaki, E. Nanba, M. González-Cuesta, 2022, Journal of enzyme inhibition and medicinal chemistry.

Regioselective synthesis and biological evaluation of spiro-sulfamidate glycosides from exo-glycals

Mahmoud Benltifa, D. Gueyrard, M. I. García-Moreno, 2009 .

Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.

F. Gamarro, C. Ortiz Mellet, J. G. García Fernández, 2019, European journal of medicinal chemistry.

Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

K. Higaki, E. Nanba, R. Pieters, 2018, Molecules.

The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study.

C. Ortiz Mellet, J. G. García Fernández, F. Ortega-Caballero, 2017, Chemistry.

Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.

K. Higaki, E. Nanba, C. Ortiz Mellet, 2016, European journal of medicinal chemistry.

A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.

Kei Yura, Yasubumi Sakakibara, Katsumi Higaki, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase.

A. Llebaria, A. Trapero, Meritxell Egido-Gabás, 2011, Organic & biomolecular chemistry.

Generalized anomeric effect in gem-diamines: stereoselective synthesis of alpha-N-linked disaccharide mimics.

C. Ortiz Mellet, J. G. García Fernández, M. Aguilar-Moncayo, 2009, Organic letters.

Synthesis and Comparative Glycosidase Inhibitory Properties of Reducing Castanospermine Analogues

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2005 .

A Fluorescent sp2‐Iminosugar With Pharmacological Chaperone Activity for Gaucher Disease: Synthesis and Intracellular Distribution Studies

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2010, Chembiochem : a European journal of chemical biology.

Chaperone Activity of Bicyclic Nojirimycin Analogues for Gaucher Mutations in Comparison with N‐(n‐nonyl)Deoxynojirimycin

Yoshiyuki Suzuki, K. Higaki, C. Ortiz Mellet, 2009, Chembiochem : a European journal of chemical biology.

o-Xylylene protecting group in carbohydrate chemistry: application to the regioselective protection of a single vic-diol segment in cyclodextrins.

J. L. Jiménez Blanco, C. Ortiz Mellet, J. G. García Fernández, 2013, The Journal of organic chemistry.

Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers.

C. Ortiz Mellet, J. G. García Fernández, P. Compain, 2017, Journal of materials chemistry. B.

Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier.

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2014, Organic & biomolecular chemistry.

Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-d-Fructose Dianhydrides (DFAs)

J. M. Benito, M. I. García-Moreno, J. M. Fernández, 2008, Molecules.

6‐Amino‐6‐deoxy‐5,6‐di‐N‐(N′‐octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β‐Glucosidase

J. Sussman, I. Silman, C. Ortiz Mellet, 2009, Chembiochem : a European journal of chemical biology.

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids

F. Gamarro, C. Ortiz Mellet, J. G. García Fernández, 2019, Molecules.

Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1 gangliosidosis.

Y. Sakakibara, K. Yura, K. Higaki, 2012, Chemical communications.

Synthesis and glycosidase inhibitory activity of isourea-type bicyclic sp2-iminosugars related to galactonojirimycin and allonojirimycin

C. Ortiz Mellet, J. G. García Fernández, C. O. Mellet, 2012 .

Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity.

T. Wrodnigg, C. Ortiz Mellet, J. G. García Fernández, 2010, Bioorganic & medicinal chemistry.

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring.

J. Turkenburg, G. Davies, C. Ortiz Mellet, 2009, Organic & biomolecular chemistry.

Synthesis and biological evaluation of guanidine-type iminosugars.

J. G. García Fernández, M. I. García-Moreno, Paula Díaz-Pérez, 2008, The Journal of organic chemistry.

Synthesis and evaluation of isourea-type glycomimetics related to the indolizidine and trehazolin glycosidase inhibitor families.

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2003, The Journal of organic chemistry.

Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2002, Chemical communications.

Molecular Basis for β‐Glucosidase Inhibition by Ring‐Modified Calystegine Analogues

G. Davies, C. Ortiz Mellet, J. G. García Fernández, 2008, Chembiochem : a European journal of chemical biology.

Pseudoamide-type pyrrolidine and pyrrolizidine glycomimetics and their inhibitory activities against glycosidases.

J. G. García Fernández, M. I. García-Moreno, David Rodríguez-Lucena, 2004, The Journal of organic chemistry.

Synthesis of Calystegine B2, B3, and B4 Analogues: Mapping the Structure‐Glycosidase Inhibitory Activity Relationships in the 1‐Deoxy‐6‐oxacalystegine Series

M. I. García-Moreno, J. M. Fernández, C. Mellet, 2004 .

sp2-Iminosugars as chemical mimics for glycodrug design

J. G. García Fernández, C. O. Mellet, J. M. Fernandez, 2020 .

One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2002, Carbohydrate research.

Synthesis and evaluation of calystegine B2 analogues as glycosidase inhibitors.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2001, The Journal of organic chemistry.

Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell.

C. Ortiz Mellet, P. Compain, J. Nierengarten, 2018, Chemistry.

Rigid spacer-mediated synthesis of bis-spiroketal ring systems: stereoselective synthesis of nonsymmetrical spiro disaccharides.

J. G. García Fernández, P. Balbuena, M. I. García-Moreno, 2005, Organic letters.

Intramolecular benzyl protection delivery: a practical synthesis of DMDP and DGDP from D-fructose.

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2006, Organic letters.

1,2,3-Triazoles and related glycoconjugates as new glycosidase inhibitors

C. O. Mellet, J. M. Fernandez, R. Duval, 2005 .

Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics

M. González-Cuesta, C. Ortiz Mellet, J. G. García Fernández, 2022, ACS omega.