M. Hirama*

发表

A study on mechanisms of toxic actions of ciguatoxins: existence of functional relationship between CTX3C and charged residues of voltage sensors in Nav1.4 sodium channel

M. Inoue, M. Hirama, K. Yamaoka, 2011, Forensic Toxicology.

Addressing the analytical challenges for the detection of ciguatoxins using an electrochemical biosensor.

M. Campàs, C. O’Sullivan, J. Caixach, 2020, Analytical chemistry.

The First Total Synthesis of Gravicycle

M. Hirama, I. Sato, K. Ueda, 2012 .

Synthesis of trans-fused tetrahydrooxepins: stereoselective allylation of sulfur or fluoro-substituted tetrahydrooxepins.

M. Hirama, Shoji Kobayashi, Makiko Hori, 2008, Carbohydrate research.

A formal total synthesis of (+)-pinnatoxin A.

M. Inoue, M. Hirama, T. Noda, 2004, Angewandte Chemie.

Stereocontrolled synthesis of the ABCDE ring moiety of ciguatoxin CTX3C

M. Hirama, T. Oishi, Shoji Kobayashi, 2004 .

Synthesis of the fully functionalized ABCDE ring moiety of ciguatoxin.

H. Oguri, M. Hirama, Shoji Kobayashi, 2004, Organic letters.

Divergent synthesis of the tetracyclic ethers of 6-X-7-6 ring systems

M. Inoue, M. Hirama, J. Wang, 2003 .

Convergent synthesis of the HIJKLM ring fragment of ciguatoxin CTX3C

M. Inoue, M. Hirama, T. Oishi, 2002 .

Convergent synthesis of the EFGH ring fragment of ciguatoxin CTX3C

H. Oguri, M. Inoue, M. Hirama, 2001 .

Solution structures of C-1027 apoprotein and its complex with the aromatized chromophore.

T. Tanaka, T. Otani, M. Hirama, 2001, Journal of molecular biology.

Remarkable kinetic solvent isotope effect on the cycloaromatization of C-1027 chromophore, a 9-membered enediyne, and the thermochemistry

Ken‐ichiro Yoshida, T. Otani, M. Hirama, 1994 .

Synthesis and Reactions of Monosilylated 1,3,5-Hexatriyne and 1,3,5,7-Octatetrayne. Total Synthesis of Caryoynencins.

M. Yamaguchi, H. Nishihara, M. Hirama, 1994 .

Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells*

E. Kinoshita, M. Inoue, K. Miyazaki, 2009, Journal of Biological Chemistry.

Benzannelation alters the rate limiting step in enediyne cycloaromatization

M. Hirama, Mikihiro Takahashi, Toshio Kaneko, 1999 .

Total synthesis of avermectin B1a revisited

M. Hirama, Shuji Yamashita, Y. Hayashi, 2015, The Journal of Antibiotics.

Enantiospecific synthesis of the spiroacetal unit of avermectin b1a

M. Hirama, S. Ito, T. Nakamine, 1986 .

Enantioselective synthesis of the AB ring fragment of gambiertoxin 4B. Implication for the absolute configuration of gambiertoxin 4B and ciguatoxin

N. Harada, Toshio Suzuki, T. Yasumoto, 1991 .

Palladium catalyzed stereospecific cyclization of hydroxy epoxides. Stereocontrolled synthesis of cis- and trans-2-alkenyl-3-hydroxytetrahydropyrans

Toshio Suzuki, M. Hirama, O. Sato, 1990 .

A simple and efficient synthesis of the naphthoate moiety of neocarzinostatin chromophore

Toshio Suzuki, M. Hirama, Kazunobu Takahashi, 1992 .

Convergent synthesis of the ABC-ring moiety of zoanthenol: Intramolecular Mizoroki-Heck reaction

H. Oguri, M. Hirama, Go Hirai, 2001 .

Synthesis-based approach toward direct sandwich immunoassay for ciguatoxin CTX3C.

H. Oguri, T. Tsumuraya, I. Fujii, 2003, Journal of the American Chemical Society.

New convenient, enantiospecific synthesis of (S,S)- and (R,R)-2,2′-bipyrrolidine derivatives

H. Kuzume, M. Hirama, M. Shiro, 1995 .

Highly Enantioselective Dihydroxylation of Trans-Disubstituted and Monosubstituted Olefins

M. Hirama, T. Oishi, M. Hirama*, 1989 .

Concise Total Synthesis of (±)‐Lycodine

M. Hirama, C. Tsukano, Y. Takemoto, 2010 .

Enantioselective synthesis of the fully functionalized ABC ring of zoanthenol.

H. Oguri, M. Hirama, Shuji Yamashita, 2008, Chemistry, an Asian journal.

Use of the E-vinyloxyborane derived from S-phenyl propanethioate for stereospecific aldol-type condensation. A simplified synthesis of the prelog-djerassi lactonic acid

D. Garvey, M. Hirama, S. Masamune, 1980 .

A new entry into the synthesis of the strychnos indole alkaloids containing 19,20-double bond via the thio-claiser rearrangement

M. Hirama, K. Ogasawara, S. Takano, 1982 .

Solvent-mediated Tuning of the Regioselectivity of Intramolecular Diaryl Ether Formation: Total Synthesis of (+)-Aspercyclide C

M. Hirama, Shuji Yamashita, Y. Hayashi, 2014 .

Total synthesis of aspercyclides A and B via intramolecular oxidative diaryl ether formation.

M. Hirama, I. Sato, Tatsuya Yoshino, 2012, Organic letters.

Stereoselective synthesis of zoanthenol ABC-ring by radical strategy

M. Hirama, Shuji Yamashita, Y. Hayashi, 2013 .

Competent Route to Unsymmetric Dimer Architectures: Total Syntheses of (-)-Lycodine and (-)-Complanadines A and B, and Evaluation of Their Neurite Outgrowth Activities.

E. Kwon, H. Shirakawa, S. Kaneko, 2017, Chemistry.

Ciguatera incidence and fish toxicity in Okinawa, Japan.

T. Yasumoto, M. Hirama, Kentaro Yogi, 2010, Toxicon : official journal of the International Society on Toxinology.

Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons

C. Vale, M. Vieytes, L. Botana, 2018, Toxins.

A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage‐dependent sodium channels

M. Inoue, K. Miyazaki, M. Hirama, 2004, British journal of pharmacology.

Total syntheses of complanadines A and B.

E. Kwon, M. Hirama, C. Tsukano, 2013, Angewandte Chemie.

Synthetic study of the kedarcidin chromophore: Efficient construction of the aryl alkyl ether linkage

S. Kawata, M. Hirama*, 1998 .

Total synthesis and related studies of large, strained, and bioactive natural products

M. Hirama, M. Hirama*, 2016, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Recent Advances in the Synthetic Studies of Nine-membered Enediyne Antitumor Antibiotics

M. Hirama, I. Sato, M. Hirama*, 2010 .

Secure route to the epoxybicyclo[7.3.0]dodecadienediyne core of the kedarcidin chromophore.

Y. Koyama, M. Hirama, I. Sato, 2008, Chemical communications.

Synthesis of the bicyclo[7.3.0]dodecadiyne core of the maduropeptin chromophore.

Nobuki Kato, M. Inoue, M. Hirama, 2008, Chemistry, an Asian journal.

Efficient construction of the kedarcidin chromophore ansamacrolide.

Y. Koyama, M. Hirama, M. J. Lear, 2005, Organic letters.

Synthesis of the C-1027 chromophore framework through atropselective macrolactonization.

M. Inoue, M. Hirama, Suguru Hatano, 2004, Angewandte Chemie.

Synthesis of the bicyclo[7.3.0]dodecatrienediyne core of the C-1027 chromophore.

M. Inoue, M. Hirama, Suguru Hatano, 2004, Organic letters.

Convergent approach to the maduropeptin chromophore: aryl ether formation of (R)-3-aryl-3-hydroxypropanamide and cyclization of macrolactam

Nobuki Kato, M. Hirama, S. Shimamura, 2004 .

Synthetic studies toward C-1027 chromophore: construction of a highly unsaturated macrocycle

M. Inoue, M. Hirama, Takeo Sasaki, 2001 .

A Direct and Efficient α-Selective Glycosylation Protocol for the Kedarcidin Sugar, L-Mycarose: AgPF6 as a Remarkable Activator of 2-Deoxythioglycosides.

M. Hirama, M. J. Lear, Fumihiko Yoshimura, 2001, Angewandte Chemie.

Synthetic study of kedarcidin chromophore: atropselective construction of the ansamacrolide

S. Kawata, Fumihiko Yoshimura, M. Hirama*, 1999 .

Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine

M. Hirama, M. J. Lear, M. Hirama*, 1999 .

Synthetic Study of C - 1027 Chromophore: Enantioselective Synthesis of β - Tyrosine Moiety and Effective Aryl Ether Formation

M. Hirama, I. Sato, Tsukasa Kikuchi, 1999 .

Synthetic Study of the Kedarcidin Chromophore: Efficient Construction of the Aryl Alkyl Ether Linkage.

S. Kawata, M. Hirama*, 1999 .

Synthetic Study of Kedarcidin Chromophore: Revised Structure

M. Hirama, S. Kawata, S. Ashizawa, 1997 .

Palladium-catalyzed coupling of alkenyl iodides with ethynyl oxiranes: Synthesis of epoxy enediyne core intermediates related to neocarzinostatin chromophore

M. Hirama, Shoji Kobayashi, R. S. Reddy, 1996 .

Synthesis and Characterization of Nine-Membered Cyclic Enediynes, Models of the C-1027 and Kedarcidin Chromophores: Equilibration with a p-Benzyne Biradical and Kinetic Stabilization

M. Hirama, K. Iida, M. Hirama*, 1995 .

EFFICIENT ROUTE TO THE NINE-MEMBERED CYCLIC DIYNE SYSTEM : TUNING OF THE EXTREMELY FACILE COPE REARRANGEMENT OF 1,5-DIYNE

M. Hirama, K. Iida, M. Hirama*, 1994 .

Synthesis of the entire carbon framework of the kedarcidin chromophore aglycon.

Y. Koyama, M. J. Lear, Fumihiko Yoshimura, 2007, Chemical communications.

Use of polystyrene-supported DBU in the synthesis and alpha-selective glycosylation study of the unstable Schmidt donor of L-kedarosamine.

M. Hirama, M. J. Lear, Fumihiko Yoshimura, 2004, Organic letters.

Convenient Route to Both Enantiomerically Pure Forms of trans-4,5-Dihydroxy-2-cyclopenten-1-one: Efficient Synthesis of the Neocarzinostatin Chromophore Core

M. Hirama, T. Oishi, H. Sakazaki, 2001 .

The 10-membered ring analogs of neocarzinostatin chromophore: design, synthesis and mode of decomposition

M. Hirama, K. Fujiwara, Y. Fukazawa, 1989 .

Asymmetric total synthesis of (-)-merrilactone A: use of a bulky protecting group as long-range stereocontrolling element.

Takaaki Sato, M. Inoue, M. Hirama, 2006, Angewandte Chemie.

Total Synthesis of Limonin.

M. Hirama, Shuji Yamashita, Y. Hayashi, 2015, Angewandte Chemie.

A concise synthesis of the pentacyclic framework of cortistatins.

M. Hirama, Shuji Yamashita, K. Iso, 2008, Organic letters.

Asymmetric Michael addition of nitroalkanes to prochiral acceptors catalyzed by proline rubidium salts

M. Yamaguchi, T. Shiraishi, M. Hirama, 1997 .

CATALYTIC ASYMMETRIC MICHAEL ADDITION OF NITROALKANE TO ENONE AND ENAL

M. Yamaguchi, T. Shiraishi, M. Hirama, 1994 .

Cell immunolocalization of ciguatoxin-like compounds in the benthic dinoflagellate Gambierdiscus australes M. Chinain & M.A. Faust by confocal microscopy.

M. Campàs, M. Pelin, T. Tsumuraya, 2022, Harmful algae.

Total synthesis of a protected aglycon of the kedarcidin chromophore.

Y. Koyama, I. Sato, Isao Ohashi, 2009, Angewandte Chemie.

Friedel–Crafts β‐Silylvinylations

M. Yamaguchi, M. Hirama, A. Hayashi, 1997 .

Enantio-Controlled Synthesis of the AB Ring Moiety of Ciguatoxin

S. Hishiyama, H. Oguri, T. Oishi, 1995 .

A convergent total synthesis of the kedarcidin chromophore: 20-years in the making

Shuji Yamashita, M. J. Lear, K. Hirai, 2019, The Journal of Antibiotics.

Investigation of the total synthesis of N1999-A2: implication of stereochemistry.

Y. Sugiura, S. Kobayashi, D. Sasaki, 2001, Journal of the American Chemical Society.

Total synthesis of cortistatins A and J.

M. Hirama, Shuji Yamashita, K. Iso, 2011, The Journal of organic chemistry.

Inhibition of brevetoxin binding to the voltage-gated sodium channel by gambierol and gambieric acid-A.

M. Satake, T. Yasumoto, M. Inoue, 2003, Toxicon : official journal of the International Society on Toxinology.

Structure of Adduct Formed from α-Trichlorostannyl Ketone and Trichloroethynyltin a Direct Evidence for the Carbostannylation of Alkynyl Metals

M. Yamaguchi, M. Hirama, C. Kabuto, 1993 .

Carbamate mediated 1,3-asymmetric induction. A stereoselective synthesis of acyclic 1,3-diol systems

M. Hirama, Mitsuko Uei, M. Hirama*, 1982 .

Neocarzinostatin Complex: Chromophore Analogs, Binding Structure and Stabilization Mechanism.

M. Hirama*, 1994 .

Synthesis and Chemistry of Nine Membered Cyclic Enediyne Chromophores of Chromoprotein Antitumor Antibiotics

M. Hirama, M. Hirama*, 1997 .

Production of monoclonal antibodies for sandwich immunoassay detection of Pacific ciguatoxins.

T. Tsumuraya, I. Fujii, M. Hirama, 2010, Toxicon : official journal of the International Society on Toxinology.

Production of monoclonal antibodies for sandwich immunoassay detection of ciguatoxin 51-hydroxyCTX3C.

M. Inoue, T. Tsumuraya, I. Fujii, 2006, Toxicon : official journal of the International Society on Toxinology.

Untitled Document

K. Maeda, H. Oguri, M. Hirama, 2001 .

Effect of ciguatoxin 3C on voltage-gated Na+ and K+ currents in mouse taste cells.

T. Yasumoto, G. Rossini, M. Inoue, 2006, Chemical senses.

Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology.

T. Hishinuma, M. Mizugaki, Toshio Suzuki, 2003, Prostaglandins, leukotrienes, and essential fatty acids.

Total synthesis of the maduropeptin chromophore aglycon.

M. Inoue, S. Shimamura, Kazuo Komano, 2007, Journal of the American Chemical Society.

Synthesis and preliminary biological evaluation of truncated zoanthenol analogues.

M. Hayashi, H. Oguri, M. Hirama, 2004, Bioorganic & medicinal chemistry letters.

Chemistry and antimicrobial activity of caryoynencins analogs.

H. J. Park, M. Yamaguchi, M. Hirama, 1995, Journal of medicinal chemistry.

First toxin profile of ciguateric fish in Madeira Arquipelago (Europe).

C. Vale, L. Botana, P. Vale, 2010, Analytical chemistry.

Proton NMR studies on the chromophore binding structure in neocarzinostatin complex

M. Mizugaki, Toŝhiyuki Tanaka, S. Imajo, 1991 .

Phage-display selection of antibodies to the left end of CTX3C using synthetic fragments.

K. Tsumoto, I. Kumagai, M. Mizugaki, 2004, Journal of immunological methods.

Formal total synthesis of neocarzinostatin chromophore.

M. Hirama, Shoji Kobayashi, Makiko Hori, 2006, The Journal of organic chemistry.

Sensitized photooxidation of gurjunene: cleavages of the cyclopropane ring

M. Hirama, Y. Fukazawa, H. Takeshita, 1972 .

Binding of glycoglycerolipid derived from membranes of Acholeplasma laidlawii PG8 and synthetic analogues to lymphoid cells.

Y. Zhang, M. Hirama, T. Oishi, 2000, Microbiology.

Total synthesis of (+)-monacolin K (mevinolin)

M. Hirama, M. Iwashita, M. Hirama*, 1983 .

A chiral total synthesis of compactin

M. Hirama, Mitsuko Uei, M. Hirama*, 1982 .

SbF5-Promoted Addition of Aldehydes to Alkynes

M. Yamaguchi, M. Hirama, A. Hayashi, 1995 .

Ortho-Vinylation Reaction of Phenols with Ethyne.

M. Yamaguchi, M. Hirama, T. Uchimaru, 1998, The Journal of organic chemistry.

Ortho-Vinylation and Ortho-Alkenylation of Phenols

M. Yamaguchi, M. Hirama, A. Hayashi, 1995 .

Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A

M. Hirama, Shuji Yamashita, K. Iso, 2009 .

Design and synthesis of a conformationally restricted analogue of the EFGH-ring system of ciguatoxin

M. Inoue, M. Hirama, N. Lee, 2009 .

Total synthesis of TMC-95A.

M. Inoue, M. Hirama, H. Sakazaki, 2003, Angewandte Chemie.

Remote C–H bond functionalization of androstane C-ring: C12-amination

M. Hirama, Shuji Yamashita, Y. Hayashi, 2013 .

Synthesis of the LMN-ring fragment of the Caribbean ciguatoxin C-CTX-1

M. Inoue, M. Hirama, Keita Yoshikawa, 2007 .

Synthesis of chiral 2,3-disubstituted 1,4-diazabicyclo [2.2.2] octane. New ligand for the osmium-catalyzed asymmetric dihydroxylation of olefins

M. Hirama, T. Oishi, M. Hirama*, 1992 .

Stereospecific total synthesis of dl-pentalenolactone

S. Danishefsky, M. Hirama, T. Harayama, 1978 .

Total Synthesis of Ciguatoxin CTX3C

M. Satake, H. Oguri, M. Inoue, 2001, Science.

Glycoglycerolipid from the Membranes of Acholeplasma laidlawii Binds to Human Immunodeficiency Virus-1 (HIV-1) and Accelerates Its Entry into Cells

Takashi Shimizu, A. Koito, M. Hirama, 2004, Current Microbiology.

Direct Formation of Reactive Alkynyltrichlorotins from 1-Alkynes, SnCl4, and Bu3N. A Mild Alkynylation Reagent of Aldehydes, Acetals, and Enones

M. Yamaguchi, M. Hirama, A. Hayashi, 1992 .

Structural factors governing stereoselective heck reaction for the construction of the oxindole portion of TMC-95A

M. Inoue, M. Hirama, H. Furuyama, 2006 .

TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells.

Masayuki Inoue, Masahiro Hirama, Haifeng Zhai, 2004, Bioorganic & medicinal chemistry letters.

Stereocontrolled synthesis of the northern part of potent proteasome inhibitor TMC-95A.

M. Inoue, M. Hirama, H. Sakazaki, 2001, Organic letters.

Convergent synthesis of the trans-fused 6-n-6-6 (n = 7–10) tetracyclic ether system based on a ring-closing metathesis reaction

M. Hirama, T. Oishi, Y. Nagumo, 1998 .

Convergent synthesis of the ABCDE-ring fragment of the Caribbean ciguatoxin C-CTX-1

M. Inoue, M. Hirama, Yuuki Ishihara, 2007 .

Practical entry into the HIJKLM ring segment of ciguatoxin CTX3C

M. Hirama, T. Oishi, M. Shoji, 2001 .

Stereocontrolled synthesis of the HIJ ring system ofciguatoxin

K. Maeda, M. Hirama, T. Oishi, 1997 .