D. Weinstein

发表

Assay of proteins in the presence of interfering materials.

A. Bensadoun, D. Weinstein, A Bensadoun, 1976, Analytical biochemistry.

Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.

Michael G. Yang, A. Doweyko, D. Shuster, 2014, Bioorganic & medicinal chemistry letters.

Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-7918

A. Doweyko, D. Shuster, J. Barrish, 2011, Journal of medicinal chemistry.

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

K. McIntyre, C. Chaudhry, L. Salter-Cid, 2019, Science Translational Medicine.

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.

Michael A. Galella, D. Shen, J. Barrish, 2018, Bioorganic & medicinal chemistry letters.

Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.

James Lin, K. McIntyre, D. Shuster, 2020, Journal of medicinal chemistry.

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

S. Spergel, K. McIntyre, D. Shuster, 2019, Journal of medicinal chemistry.

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).

S. Spergel, K. McIntyre, J. Tokarski, 2019, Journal of medicinal chemistry.

Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.

J. Tokarski, D. Xie, N. Araníbar, 2017, MedChemComm.

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain*

Stephen R. Johnson, M. Witmer, J. Tokarski, 2015, The Journal of Biological Chemistry.

Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.

James Lin, K. McIntyre, J. Tokarski, 2019, ACS medicinal chemistry letters.

DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.

B. Cravatt, T. Wucherpfennig, M. Dix, 2021, Journal of the American Chemical Society.

Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators.

A. Doweyko, J. Barrish, T. Huynh, 2009, Bioorganic & medicinal chemistry letters.

Development of a Practical Synthesis of Functionalized Azaxanthene-Derived Nonsteroidal Glucocorticoid Receptor Modulators

Thomas M. Razler, D. Conlon, Steven A. Tymonko, 2016 .

Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide

Michael G. Yang, Michael A. Galella, K. McIntyre, 2015, Journal of medicinal chemistry.

Determining competence in estimating energy needs.

D S Weinstein, A Skipper, A. Skipper, 1998, Journal of the American Dietetic Association.

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Saleem Ahmad, C. S. Madsen, Xing Chen, 2011, Bioorganic & medicinal chemistry letters.

Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment.

C. S. Madsen, Shaobin Zhuang, J. Robl, 2007, Bioorganic & medicinal chemistry letters.

Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.

J. Macor, N. Murugesan, Z. Gu, 2005, Bioorganic & medicinal chemistry letters.

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).

S. Spergel, K. McIntyre, J. Tokarski, 2019, Journal of medicinal chemistry.

Novel two-step, one-pot synthesis of primary acylureas

Michael A. Galella, A. Tebben, D. S. Weinstein, 2010 .

Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1.

M. Kirby, Saleem Ahmad, G. Chandrasena, 2004, Bioorganic & medicinal chemistry letters.