Alicia P. Higueruelo

发表

TIMBAL v2: update of a database holding small molecules modulating protein–protein interactions

Tom L. Blundell, Harry Jubb, Alicia P. Higueruelo, 2013, Database J. Biol. Databases Curation.

Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database

Tom L. Blundell, Alicia P. Higueruelo, George R. Bickerton, 2011, BMC Bioinformatics.

SInCRe—structural interactome computational resource for Mycobacterium tuberculosis

Nagasuma R. Chandra, Ramanathan Sowdhamini, Tom L. Blundell, 2015, Database J. Biol. Databases Curation.

Fragment-Based Methods for Lead Discovery

Nikolay P. Todorov, N. P. Todorov, Alicia P. Higueruelo, 2011 .

TIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial species

Tom L. Blundell, Alicia P. Higueruelo, Grace Mugumbate, 2017, Database J. Biol. Databases Curation.

Atomic Interactions and Profile of Small Molecules Disrupting Protein–Protein Interfaces: the TIMBAL Database

Alicia P. Higueruelo, T. Blundell, G. R. Bickerton, 2009, Chemical biology & drug design.

The Discovery and Characterization of Protein–Protein Interactions

Alicia P. Higueruelo, X. Salvatella, C. Bertoncini, 2010 .

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics.

Alicia P. Higueruelo, T. Blundell, G. R. Bickerton, 2009, Molecular bioSystems.

Structural biology and drug discovery for protein-protein interactions.

Harry Jubb, Alicia P. Higueruelo, Tom L Blundell, 2012, Trends in pharmacological sciences.

What Can We Learn from the Evolution of Protein-Ligand Interactions to Aid the Design of New Therapeutics?

Alicia P. Higueruelo, T. Blundell, G. R. Bickerton, 2012, PloS one.

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

Alicia P. Higueruelo, T. Blundell, W. Pitt, 2017, Journal of molecular biology.

Biophysical and computational fragment-based approaches to targeting protein–protein interactions: applications in structure-guided drug discovery

Tom L. Blundell, Alicia P. Higueruelo, Anja Winter, 2012, Quarterly Reviews of Biophysics.

MULTIPROTEIN ASSEMBLIES: MODULATING CELL ACTIVITY THROUGH TARGETING PROTEIN-PROTEIN INTERFACES

Alicia P. Higueruelo, T. Blundell, H. Jubb, 2013 .

A DFT computational study of the bis-silylation reaction of acetylene catalyzed by palladium complexes.

Alicia P. Higueruelo, A. Bottoni, G. P. Miscione, 2002, Journal of the American Chemical Society.

IRAK-4 inhibitors. Part 1: a series of amides.

Alicia P. Higueruelo, W. Pitt, D. Parry, 2008, Bioorganic & medicinal chemistry letters.

Protein-protein interactions as druggable targets: recent technological advances.

Harry Jubb, Alicia P. Higueruelo, Tom L Blundell, 2013, Current opinion in pharmacology.

Protein-Protein Interactions: Structures and Druggability

Douglas E. V. Pires, Alicia P. Higueruelo, T. Blundell, 2015 .

IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

Alicia P. Higueruelo, W. Pitt, D. Parry, 2008, Bioorganic & medicinal chemistry letters.

IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.

Alicia P. Higueruelo, Kerry Jenkins, Colin R Groom, 2008, Bioorganic & medicinal chemistry letters.

Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918

Alicia P. Higueruelo, Flavia Autore, M. O’Brien, 2021, Heliyon.

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design

Jason C Cole, David R Spring, Richard A. Sykes, 2020, J. Chem. Inf. Model..

Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents

Alicia P. Higueruelo, T. Blundell, G. McKenzie, 2023, bioRxiv.

Biophysical and computational fragment-based approaches to targeting protein–protein interactions: applications in structure-guided drug discovery

Alicia P. Higueruelo, T. Blundell, W. Pitt, 2012, Quarterly Reviews of Biophysics.

The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders.

Alicia P. Higueruelo, M. O’Brien, S. Watson, 2023, ACS medicinal chemistry letters.

Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents

Alicia P. Higueruelo, T. Blundell, G. McKenzie, 2024, bioRxiv.