J. Somoza

发表

Clinical targeting of HIV capsid protein with a long-acting small molecule

J. R. Somoza, W. Sundquist, Xiaohong Liu, 2020, Nature.

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.

W. Jacobs, A. Banerjee, E. Dubnau, 1994, Science.

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.

J. R. Somoza, D. McRee, Biching Sang, 2004, Structure.

Peptide ketobenzoxazole inhibitors bound to cathepsin K.

J. R. Somoza, M. Mcgrath, J. Palmer, 2003, Biochemistry.

Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV.

Todd C Appleby, J. R. Somoza, Xiaohong Liu, 2011, Journal of molecular biology.

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.

J. Chandrasekhar, J. R. Somoza, M. Mcgrath, 2016, Journal of medicinal chemistry.

Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.

R J Fletterick, H Luecke, R. Fletterick, 1997, Biochemistry.

The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.

J. R. Somoza, J. Palmer, J. Ho, 2002, Journal of molecular biology.

Crystal structure of human cathepsin V.

J. R. Somoza, M. Mcgrath, J. Palmer, 2000, Biochemistry.

Crystal structure of human cathepsin S

J T Palmer, J. R. Somoza, M. Mcgrath, 1998, Protein science : a publication of the Protein Society.

3-heterocyclyl quinolone inhibitors of the HCV NS5B polymerase.

J. Janc, J. Ho, K. Brameld, 2012, Bioorganic & medicinal chemistry letters.

Quinolones as HCV NS5B polymerase inhibitors.

J. R. Somoza, J. Janc, K. Brameld, 2011, Bioorganic & medicinal chemistry letters.

Expression, purification, crystallization and preliminary X-ray diffraction studies of human cathepsin F complexed with an irreversible vinyl sulfone inhibitor.

J. R. Somoza, J. Palmer, K. Mortara, 2002, Acta crystallographica. Section D, Biological crystallography.

Coupling between trans/cis proline isomerization and protein stability in staphylococcal nuclease

J. R. Somoza, J. Markley, K. Prehoda, 1996, Protein science : a publication of the Protein Society.

The characterization of idelalisib binding to PI3Kδ 1 Structural, biochemical and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta*

J. R. Somoza, Melanie H. Wong, M. Mcgrath, 2015 .

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.

J. R. Somoza, Melanie H. Wong, W. Tse, 2015, Biochemistry.

The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.

J. R. Somoza, M. Mcgrath, B. Katz, 2003, Structure.

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.

J. R. Somoza, Melanie H. Wong, W. Tse, 2015, Biochemistry.

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

J. R. Somoza, Dan Wang, J. Falgueyret, 2005, Journal of medicinal chemistry.