Boris N Kholodenko

发表

Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

Oleksii S. Rukhlenko, Marian Anghel, Richard G Posner, 2018, PLoS Comput. Biol..

Control analysis for autonomously oscillating biochemical networks.

Hans V Westerhoff, Jacky L Snoep, Boris N Kholodenko, 2002, Biophysical journal.

Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

Tapesh Santra, Oleksii S. Rukhlenko, Nicole E Radde, 2018, Scientific Reports.

Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols.

Dirk Fey, Boris N Kholodenko, Anatoly Kiyatkin, 2017, Methods in molecular biology.

Systems biology embedded target validation: improving efficacy in drug discovery

Walter Kolch, William Fitzmaurice, Drieke Vandamme, 2022 .

Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation.

Herbert M Sauro, Vijay Chickarmane, Boris N Kholodenko, 2007, Journal of theoretical biology.

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling.

Oleksii S. Rukhlenko, Leonidas G Alexopoulos, Walter Kolch, 2018, Cell systems.

Network-based identification of feedback modules that control RhoA activity and cell migration.

Kwang-Hyun Cho, Walter Kolch, Olivier Pertz, 2015, Journal of molecular cell biology.

Bistability from double phosphorylation in signal transduction

Marta Cascante, Fernando Ortega, Boris N Kholodenko, 2006, The FEBS journal.

The APC network regulates the removal of mutated cells from colonic crypts.

Kwang-Hyun Cho, Walter Kolch, Je-Hoon Song, 2014, Cell reports.

Catching transcriptional regulation by thermostatistical modeling

Mariko Okada-Hatakeyama, Boris N Kholodenko, B. Kholodenko, 2012, Physical biology.

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments.

Walter Kolch, Boris N Kholodenko, Marc R Birtwistle, 2012, Molecular bioSystems.

Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle

Boris N Kholodenko, B. Kholodenko, N. P. Kaimachnikov, 2009, The FEBS journal.

Endocytosis and signalling: A meeting with mathematics

Boris N Kholodenko, Marc R Birtwistle, B. Kholodenko, 2009, Molecular oncology.

Signaling cascades as cellular devices for spatial computations

Jörg Stelling, Boris N Kholodenko, J. Stelling, 2009, Journal of mathematical biology.

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

Neil O Carragher, Walter Kolch, John C Dawson, 2016, Cell systems.

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.

Oleksii S. Rukhlenko, Richard G Posner, William S Hlavacek, 2019, Seminars in cancer biology.

Frequency modulation of ERK activation dynamics rewires cell fate

Dirk Fey, Olivier Pertz, Matthias Peter, 2016, Molecular systems biology.

Four‐dimensional dynamics of MAPK information‐processing systems

Boris N Kholodenko, Marc R Birtwistle, B. Kholodenko, 2009, Wiley interdisciplinary reviews. Systems biology and medicine.

Rac1 and RhoA: Networks, loops and bistability

Boris N Kholodenko, Lan K Nguyen, Alex von Kriegsheim, 2018, Small GTPases.

Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops*

Boris N Kholodenko, Anatoly Kiyatkin, Jan B Hoek, 2006, Journal of Biological Chemistry.

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

Walter Kolch, Dirk Fey, Matthias Fischer, 2015, Science Signaling.

Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains.

Boris N Kholodenko, Jan B Hoek, B. Kholodenko, 2006, Bio Systems.

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

Walter Kolch, Edina Rosta, Boris N Kholodenko, 2015, Angewandte Chemie.

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

Walter Kolch, Boris N Kholodenko, Lan K Nguyen, 2013, Cell Communication and Signaling.

Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades

Boris N Kholodenko, Jan B Hoek, B. Kholodenko, 2006, Molecular systems biology.

A dynamic model of the hypoxia-inducible factor 1&agr; (HIF-1&agr;) network

Murtaza M Tambuwala, Boris N Kholodenko, Lan K Nguyen, 2013, Journal of Cell Science.

Effects of sequestration on signal transduction cascades

Nils Blüthgen, Hanspeter Herzel, Frank J Bruggeman, 2006, The FEBS journal.

MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?

Boris N Kholodenko, B. Kholodenko, 2002, Trends in cell biology.

Systems-level interactions between insulin–EGF networks amplify mitogenic signaling

Jens Timmer, Thomas Maiwald, Jan Berkhout, 2009, Molecular systems biology.

Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law.

Hans V Westerhoff, Boris N Kholodenko, B. Kholodenko, 2002, Journal of theoretical biology.

Complexity of receptor tyrosine kinase signal processing.

Boris N Kholodenko, B. Kholodenko, N. Volinsky, 2013, Cold Spring Harbor perspectives in biology.

Spatially distributed cell signalling

Boris N Kholodenko, B. Kholodenko, 2009, FEBS letters.

Molecular Systems Biology Peer Review Process File Frequency Modulation of Erk Activation Dynamics Rewires Cell Fate Transaction Report

Noo Li Jeon, Dirk Fey, Olivier Pertz, 2022 .

An integrative computational approach for a prioritization of key transcription regulators associated with nanomaterial-induced toxicity.

Tapesh Santra, Oleksii S. Rukhlenko, Walter Kolch, 2019, Toxicological sciences : an official journal of the Society of Toxicology.