B. Park

发表

Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

C. Wolf, N. Kitteringham, B. K. Park, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome

N. Kitteringham, B. K. Park, R. Eakins, 2015, Scientific Reports.

Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen‐Induced Liver Injury

J. Dear, J. Bonventre, B. K. Park, 2015, Hepatology.

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies

M. Pirmohamed, P. Dargan, J. Dear, 2017, The lancet. Gastroenterology & hepatology.

Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury

J. Dear, B. K. Park, D. Antoine, 2015, Scientific Reports.

3 The pharmacology of the cytochrome P450 enzyme system

M. Pirmohamed, N. Kitteringham, B. K. Park, 1998 .

Idiosyncratic Drug Reactions

M. Pirmohamed, B. K. Park, S. Madden, 1996 .

Metabolism of fluorine-containing drugs.

N. Kitteringham, B. K. Park, P. O’Neill, 2001, Annual review of pharmacology and toxicology.

Toxicological Consequences of Drug–Drug Interactions

Dominic P. Williams, B. K. Park, D. Antoine, 2010 .

MDM2 regulates dihydrofolate reductase activity through monoubiquitination.

B. K. Park, R. Jenkins, M. Boyd, 2008, Cancer research.

Reduction of circulating 25-hydroxyvitamin D by antipyrine.

J. Mucklow, C. Dollery, M. Brodie, 1979, British journal of clinical pharmacology.

Quantitative analysis of pharmacological concentrations of vitamin K1 and vitamin K1 2,3-epoxide in rat liver by high-performance liquid chromatography

B. K. Park, S. Cholerton, B. Park, 1986 .

Quantitative analysis of pharmacological levels of vitamin K1 and vitamin K1 2,3-epoxide in rabbit plasma by high-performance liquid chromatography.

B. K. Park, A. Wilson, B. Park, 1983, Journal of chromatography.

Effect of isoniazid on vitamin D metabolism and hepatic monooxygenase activity

M. Brodie, A. Boobis, B. K. Park, 1981, Clinical pharmacology and therapeutics.

Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients.

B. K. Park, D. Naisbitt, R. Jenkins, 2016, Chemical research in toxicology.

Role of bioactivation in drug-induced hypersensitivity reactions

B. K. Park, D. Naisbitt, Joseph P. Sanderson, 2006, The AAPS Journal.

Reporting of adverse drug reactions by nurses

M. Pirmohamed, T. Walley, A. Breckenridge, 2003, The Lancet.

Food , drug , insect sting allergy , and anaphylaxis Stimulation of human T cells with sulfonamides and sulfonamide metabolites

B. K. Park, D. Naisbitt, W. Pichler, 2022 .

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

M. Pirmohamed, D. Naisbitt, P. O’Neill, 1996 .

Activation of Human Dendritic Cells by p-Phenylenediamine

K. L. Mathews, D. Basketter, B. K. Park, 2007, Journal of Pharmacology and Experimental Therapeutics.

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.

Mitchell R. McGill, Dominic P. Williams, J. Dear, 2012, Journal of hepatology.

Donor‐Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Cells

T. Liloglou, N. Kitteringham, B. K. Park, 2017, Stem cells translational medicine.

Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell‐Based Therapies

Dominic P. Williams, P. Andrews, D. Hay, 2015, Stem cells translational medicine.

Metabolism and bioactivation of clozapine by human liver in vitro.

Dominic P. Williams, M. Pirmohamed, B. K. Park, 1995, The Journal of pharmacology and experimental therapeutics.

The metabolism of 2,4-dibromo [6,7-3H]17β-oestradiol in the rat: Ring-A dibromination blocks male-specific 15α-hydroxylation and catechol formation

B. K. Park, J. Maggs, P. C. Page, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

Regioselective synthesis of a-ring halogenated derivatives of 17α-ethynyloestradiol

B. K. Park, J. Maggs, P. C. Page, 1991 .

The metabolism of 2,4-dibromo-17α-ethynyl[6,7-3H]oestradiol in the rat

B. K. Park, J. Maggs, F. Hussain, 1990 .

Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management.

D. Palmer, N. Kitteringham, B. K. Park, 2018, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Safety perspectives on presently considered drugs for the treatment of COVID‐19

Amy E. Chadwick, M. Pirmohamed, S. Khoo, 2020, British journal of pharmacology.

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems.

D A Smith, D. Smith, N. Kitteringham, 1995, British journal of clinical pharmacology.

Inhibition of Dapsone‐induced Methaemoglobinaemia by Cimetidine in the Presence of Trimethoprim in the Rat

R. Russell, B. K. Park, M. Coleman, 1992, The Journal of pharmacy and pharmacology.

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

Michael R. Johnson, P. Deloukas, K. Shianna, 2011, The New England journal of medicine.

Carbamazepine is not a substrate for P-glycoprotein.

M. Pirmohamed, D. Chadwick, B. K. Park, 2001, British journal of clinical pharmacology.

The biotransformation of 17 alpha-ethynyl[3H]estradiol in the rat: irreversible binding and biliary metabolites.

B. K. Park, J. Maggs, P. Grabowski, 1982, Xenobiotica; the fate of foreign compounds in biological systems.

Mechanisms of hypertransaminemia

M. Pirmohamed, B. K. Park, B. Park, 1996 .

Activation of mianserin and its metabolites by human liver microsomes.

N. Kitteringham, B. K. Park, C. Lambert, 1989, Biochemical pharmacology.

The effect of low-dose phenobarbitone on three indices of hepatic microsomal enzyme induction.

M. Feely, B. K. Park, A. Hay, 1986, British journal of clinical pharmacology.

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 2000, Molecular pharmacology.

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 1997, The Journal of pharmacology and experimental therapeutics.

Clinical Implications of Enzyme Induction and Enzyme Inhibition

A. Breckenridge, B. K. Park, B. Park, 1981, Clinical pharmacokinetics.

Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells.

R. Glazer, B. K. Park, Xiao Zeng, 2001, Cancer research.

Direct and metabolism-dependent toxicity of sulphasalazine and its principal metabolites towards human erythrocytes and leucocytes.

M. Pirmohamed, A. Breckenridge, B. K. Park, 1991, British journal of clinical pharmacology.

Metabolic activation in drug allergies.

M. Pirmohamed, N. Kitteringham, B. K. Park, 2001, Toxicology.

Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity.

M Pirmohamed, M. Pirmohamed, N. Kitteringham, 2000, Toxicology.

Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2010, The Journal of investigative dermatology.

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1995, Pharmacology & therapeutics.

Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells.

M. Pirmohamed, B. K. Park, D. Antoine, 2010, Biochemical pharmacology.

Reactive metabolites and their role in drug reactions

Dominic P. Williams, M. Pirmohamed, N. Kitteringham, 2001, Current opinion in allergy and clinical immunology.

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation.

B. K. Park, C. Goldring, B. K. Park, 2013, Biochemical pharmacology.

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.

M. Pirmohamed, D. Hughes, B. K. Park, 2004, Pharmacogenetics.

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science.

Dominic P. Williams, B. K. Park, D. Antoine, 2008, Expert opinion on drug metabolism & toxicology.

PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals

P. Taupin, D. Walker, B. K. Park, 2009 .

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.

Dominic P. Williams, M. Pirmohamed, B. K. Park, 1995, The Journal of pharmacology and experimental therapeutics.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

S. Parapini, D. Taramelli, C. Davis, 2009, Journal of medicinal chemistry.

Human pluripotent stem cells for modeling toxicity.

N. Hanley, M. Cross, N. Kitteringham, 2012, Advances in pharmacology.

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

M. Ingelman-Sundberg, V. Lauschke, R. Weaver, 2016, Archives of Toxicology.

Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals.

Andrew A. White, Dominic P. Williams, M. Pirmohamed, 2010, The Journal of investigative dermatology.

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

J. S. Miles, N. Kitteringham, B. K. Park, 1992, The Biochemical journal.

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

J. Timmer, M. Schilling, Daniel Kaschek, 2018, npj Systems Biology and Applications.

Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury

Jan Snoeys, Michael J Liguori, Richard J Weaver, 2017, Expert opinion on drug metabolism & toxicology.

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

Nico P E Vermeulen, Jan Snoeys, Magnus Ingelman-Sundberg, 2016, Archives of Toxicology.

Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing

Min Wei Wong, B. K. Park, C. Goldring, 2018 .

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

Masayuki Yamamoto, J. Hayes, N. Kitteringham, 2010, Journal of proteomics.

Acyl glucuronides: biological activity, chemical reactivity, and chemical synthesis.

John C Lindon, Ian D Wilson, I. Wilson, 2006, Journal of medicinal chemistry.

British Journal of Clinical Pharmacology

B. Lipworth, P. Waller, G. Tucker, 2013 .

Selective Haptenation of Cellular or Extracellular Protein by Chemical Allergens: Association with Cytokine Polarization

N. Kitteringham, B. K. Park, D. Naisbitt, 2005 .

Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization.

N. Kitteringham, B. K. Park, D. Naisbitt, 2005, Chemical research in toxicology.

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.

H. Jaeschke, K. Dorko, S. Kumer, 2015, Toxicology and applied pharmacology.

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells

Amy E. Chadwick, R. Weaver, B. K. Park, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug‐induced liver injury and postinjury inflammation in mice

K. Tracey, Huan Yang, J. Stéen, 2016, Hepatology.

Plasma disposition of vitamin K1 in relation to anticoagulant poisoning.

A. Breckenridge, B. K. Park, A. Scott, 1984, British journal of clinical pharmacology.

A study of factors which determine the pharmacological response to vitamin K in coumarin anticoagulated rabbits.

B. K. Park, B. Haynes, J. A. Hart, 1984, Biochemical pharmacology.

A comparison of vitamin K antagonism by warfarin, difenacoum and brodifacoum in the rabbit.

B. K. Park, J. Leck, B. Park, 1982, Biochemical pharmacology.

Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration

Yongxiang Fang, S. Forbes, R. Aird, 2021, Hepatology.

Drug protein conjugates--VI. Role of glutathione in the metabolism of captopril and captopril plasma protein conjugates.

A. Breckenridge, B. K. Park, J. Yeung, 1983, Biochemical pharmacology.

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

H. Laverty, B. K. Park, D. Naisbitt, 2011, Chemico-biological interactions.

Problems of anticoagulation with warfarin in hyperthyroidism.

A. Toft, B. K. Park, S. Cholerton, 1986, The Quarterly journal of medicine.

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells*

L. Djouhri, S. Sethu, N. Kitteringham, 2012, The Journal of Biological Chemistry.

Circulating microRNAs as potential markers of human drug‐induced liver injury

Jonathan Moggs, D. Webb, J. Dear, 2011, Hepatology.

Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer

H. Grabsch, W. Greenhalf, Eithne Costello, 2010, Gut.

Are chemically reactive metabolites responsible for adverse reactions to drugs?

M. Pirmohamed, D. Smith, N. Kitteringham, 2002, Current drug metabolism.

Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells.

Eithne Costello, J. Neoptolemos, S. Tonack, 2010, Carcinogenesis.

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.

Paul J Thornalley, Masayuki Yamamoto, N. Kitteringham, 2012, The Biochemical journal.

Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.

B. K. Park, P. O’Neill, J. Maggs, 2013, Organic & biomolecular chemistry.

Roles of Nrf2 in drug and chemical toxicity

B. K. Park, I. Copple, James Murray, 2016 .

The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity.

N. Kitteringham, B. K. Park, C. Goldring, 2010, Handbook of experimental pharmacology.

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

Dave T. Gerrard, L. Sundstrom, N. Hanley, 2013, Hepatology.

HIV and drug allergy

M Pirmohamed, M. Pirmohamed, B. K. Park, 2001, Current opinion in allergy and clinical immunology.

The role of metabolic activation in drug-induced hepatotoxicity.

Munir Pirmohamed, Dominic P. Williams, M. Pirmohamed, 2005, Annual review of pharmacology and toxicology.

CDDO-Imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1.

M. Sporn, A. Lister, B. K. Park, 2020, Journal of medicinal chemistry.

Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor.

J. Ashby, P. Lefevre, W. Pennie, 2000, Biochemical pharmacology.

The effect of 2,2'-substitution on the metabolism and toxicity of dapsone in vitro and in vivo.

B. K. Park, S. Ward, M. Coleman, 1998, Environmental toxicology and pharmacology.

Role of Nrf2 in protection against acute kidney injury.

B. K. Park, I. Copple, Luke M. Shelton, 2013, Kidney international.

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo

M. Pirmohamed, B. K. Park, D. Naisbitt, 2001, British journal of pharmacology.

Time course toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration.

D. Smith, R. Walsh, P. Brain, 2004, Chemical Research in Toxicology.

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.

M. Pirmohamed, D. Chadwick, M. Britschgi, 2003, Molecular pharmacology.

Cortisol metabolism in vitro—II. Species difference

B. K. Park, D. Back, J. Maggs, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Dexamethasone metabolism in vitro: Species differences

B. K. Park, E. Tomlinson, D. Back, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

Dexamethasone Metabolism in Species Differences Vitro

B. K. Park, E. Tomlinson, D. Back, 1997 .

Cortisol metabolism by human liver in vitro—I. Metabolite identification and inter-individual variability

B. K. Park, D. Back, J. Maggs, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.

B. K. Park, D. Back, J. Maggs, 1987, British journal of clinical pharmacology.

Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy

B. K. Park, P. Friedmann, L. Rhodes, 1995, The British journal of dermatology.

The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man.

A. Breckenridge, B. K. Park, M. Coleman, 1990, British journal of clinical pharmacology.

Managing the challenge of chemically reactive metabolites in drug development

Ian D. Wilson, Alan Boobis, Chris E. P. Goldring, 2011, Nature Reviews Drug Discovery.

Stereoselective interaction between the R enantiomer of warfarin and cimetidine.

A. Breckenridge, B. K. Park, S. Cholerton, 1986, British journal of clinical pharmacology.

Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase.

B. K. Park, D. Naisbitt, R. Jenkins, 2015, Chemical research in toxicology.

Immune pathomechanism of drug hypersensitivity reactions.

B. K. Park, D. Naisbitt, W. Pichler, 2011, The Journal of allergy and clinical immunology.

Activation of T cells by carbamazepine and carbamazepine metabolites.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2006, The Journal of allergy and clinical immunology.

T cell responses to drugs and drug metabolites.

B. K. Park, D. Naisbitt, C. Earnshaw, 2014, Experientia supplementum.

Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals1

M. Pirmohamed, B. K. Park, D. Naisbitt, 2000, The Journal of Immunology.

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.

J. Bibby, N. Kitteringham, B. K. Park, 2016, Journal of medicinal chemistry.

Effect of chloroquine and primaquine on antipyrine metabolism.

B. K. Park, D. Back, S. Ward, 1983, British journal of clinical pharmacology.

Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis.

J. Dear, B. K. Park, C. Goldring, 2014, British journal of clinical pharmacology.

The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers

P. Watkins, D. Pisetsky, B. K. Park, 2012, Clinical pharmacology and therapeutics.

Catecholestrogens as mediators of carcinogenesis: correlation of aromatic hydroxylation of estradiol and its fluorinated analogs with tumor induction in Syrian hamsters.

B. K. Park, J. Maggs, T. L. Gilchrist, 1994, Molecular pharmacology.

“Danger” Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells

B. K. Park, D. Naisbitt, S. Lavergne, 2009, Journal of Pharmacology and Experimental Therapeutics.

Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells

A. Pettitt, F. Falciani, N. Kitteringham, 2021, Scientific Reports.

J. Dear, B. K. Park, C. Goldring, 2012 .

Efficient synthesis of 1β-O-acyl glucuronides via selective acylation of allyl or benzyl d-glucuronate

John R. Harding, B. K. Park, J. Maggs, 2007 .

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Yongxiang Fang, L. Rainbow, J. Sutherland, 2018, Archives of Toxicology.

Assessing the safety of stem cell therapeutics.

Jens Kurth, Gopalan Narayanan, Hugh Laverty, 2011, Cell stem cell.

Vesicular stomatitis virus infection induces a nuclear DNA-binding factor specific for the interferon-stimulated response element

J. Coligan, Y. Kanno, K. Ozato, 1995, Journal of virology.

The relationship between inhibition of vitamin K1 2,3-epoxide reductase and reduction of clotting factor activity with warfarin.

A. Breckenridge, B. K. Park, C. Hay, 1988, British journal of clinical pharmacology.

Clinical application of whole-genome sequenc- ing in patients with primary immunodeficiency

B. K. Park, D. Naisbitt, R. Jenkins, 2015 .

Characterization of Clozapine-Responsive Human T Cells

M. Pirmohamed, B. K. Park, D. Naisbitt, 2020, The Journal of Immunology.

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.

B. K. Park, James Chadwick, P. O’Neill, 2009, Bioorganic & medicinal chemistry.

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Dominic P. Williams, B. K. Park, James Chadwick, 2004, Journal of medicinal chemistry.

Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC)

N. Kitteringham, B. K. Park, C. Goldring, 2008, Phytotherapy research : PTR.

Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore

Ian D. Wilson, John R. Harding, Dominic P. Williams, 2008, Journal of Pharmacology and Experimental Therapeutics.

Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation.

B. K. Park, J. Maggs, B K Park, 2000, Chemico-biological interactions.

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

B. K. Park, D. Naisbitt, A. Owen, 2015, AIDS.

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2013, Chemical research in toxicology.

Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats.

Alison J. Foster, Dominic P. Williams, A. Czich, 2016, Toxicology letters.

Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro.

N. Kitteringham, B. K. Park, C. Goldring, 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

The enterohepatic circulation of the metabolites of 17α-ethynyl[3H]estradiol in the rat

J. Maggs, P. Grabowski, B. Park, 1983 .

Characterisation of the toxic metabolite(s) of naphthalene.

M Pirmohamed, Dominic P. Williams, M. Pirmohamed, 1996, Toxicology.

The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine

Amy E. Chadwick, Dominic P. Williams, M. Monshouwer, 2020, Toxicology and applied pharmacology.

Drug-protein conjugates--X. The role of protein conjugation in the disposition of dinitrofluorobenzene.

N. Kitteringham, J. Maggs, P. Grabowski, 1986, Biochemical pharmacology.

A comparative study of biliary and urinary 2-hydroxylated metabolites of [6,7-3H]17 alpha-ethynylestradiol in women.

J. Maggs, B. Park, 1985, Contraception.

Drug-protein conjugates--V. Sex-linked differences in the metabolism and irreversible binding of 17 alpha-ethinylestradiol in the rat.

B. K. Park, J. Maggs, P. Grabowski, 1983, Biochemical pharmacology.

Drug protein conjugates--III. Inhibition of the irreversible binding of ethinylestradiol to rat liver microsomal protein by mixed-function oxidase inhibitors, ascorbic acid and thiols.

J. Maggs, P. Grabowski, B. Park, 1983, Journal of steroid biochemistry.

Protection of catechol oestrogen from oxidation during enzymic hydrolysis of biliary conjugates.

B. K. Park, J. Maggs, P. Grabowski, 1983, Journal of steroid biochemistry.

Drug-protein conjugates--II. An investigation of the irreversible binding and metabolism of 17 alpha-ethinyl estradiol in vivo.

B. K. Park, J. Maggs, P. Grabowski, 1983, Biochemical pharmacology.

The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore

Julian Blagg, Iain Gardner, Dominic P. Williams, 2007, Journal of Pharmacology and Experimental Therapeutics.

Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide

B. K. Park, D. Back, H. Mönig, 2004, European Journal of Clinical Pharmacology.

Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.

K. Neftel, N. Kitteringham, B. K. Park, 1991, International archives of allergy and applied immunology.

Immunogenicity of amodiaquine in the rat.

N. Kitteringham, B. K. Park, J. Maggs, 1990, International archives of allergy and applied immunology.

Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1992, British journal of clinical pharmacology.

Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.

M. Pirmohamed, A. Breckenridge, N. Kitteringham, 1992, British journal of clinical pharmacology.

Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.

M. Pirmohamed, A. Breckenridge, D. Chadwick, 1991, British journal of clinical pharmacology.

Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues.

N. Kitteringham, B. K. Park, M. Coleman, 1990, British journal of clinical pharmacology.

Metabolism of ciamexon by human liver microsomes: an investigation into the formation of stable, chemically reactive and cytotoxic metabolites.

B. K. Park, M. Tingle, B. Park, 1990, British journal of clinical pharmacology.

A stereochemical investigation of the cytotoxicity of mianserin metabolites in vitro.

N. Kitteringham, B. K. Park, R. Riley, 1989, British journal of clinical pharmacology.

An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin.

N. Kitteringham, B. K. Park, J. Maggs, 1988, British journal of clinical pharmacology.

Role of reactive metabolites in drug-induced hepatotoxicity.

D A Smith, Dominic P. Williams, D. Smith, 2010, Handbook of experimental pharmacology.

Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation.

B. K. Park, D. Naisbitt, R. Jenkins, 2009, Chemical research in toxicology.

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

M Pirmohamed, M. Pirmohamed, N. Kitteringham, 1999, British journal of pharmacology.

Paracetamol (acetaminophen) poisoning.

J. Dear, D. Antoine, B. Park, 2015, BMJ clinical evidence.

Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitis.

N. Kitteringham, B. K. Park, J. G. Kenna, 1995, British journal of clinical pharmacology.

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity

M. Pirmohamed, B. K. Park, D. Ostrov, 2015, The Journal of allergy and clinical immunology.

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

Andrew R. Jones, M. Pirmohamed, B. K. Park, 2012, Genome Medicine.

Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions

B. K. Park, D. Naisbitt, A. Sullivan, 2018, Expert opinion on drug metabolism & toxicology.

Human leukocyte antigen (HLA)‐B*57:01‐restricted activation of drug‐specific T cells provides the immunological basis for flucloxacillin‐induced liver injury

M. Pirmohamed, Andrew Gibson, B. K. Park, 2013, Hepatology.

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress

B. K. Park, F. Mutter, I. Copple, 2015, Biochemical Society transactions.

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

N. Kitteringham, B. K. Park, C. Goldring, 2014, Journal of proteomics.

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus

D. Tuveson, I. Jacobs, U. Menon, 2015, Clinical Cancer Research.

TNF-α promoter region gene polymorphisms in HIV-positive patients with lipodystrophy

M. Pirmohamed, B. K. Park, A. Alfirevic, 2002 .

TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy.

M. Pirmohamed, B. K. Park, A. Alfirevic, 2002, AIDS.

Relative and absolute quantitative expression profiling of cytochromes P450 using isotope‐coded affinity tags

Rod B. Watson, Dominic P. Williams, N. Kitteringham, 2006, Proteomics.

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

Fiona Campbell, Andrew Owen, Eithne Costello, 2011, Molecular Cancer.

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.

Munir Pirmohamed, Steven Lane, Leon Aarons, 2012, British journal of clinical pharmacology.

Parsing interindividual drug variability: an emerging role for systems pharmacology

M. Pirmohamed, B. K. Park, R. Turner, 2015, Wiley interdisciplinary reviews. Systems biology and medicine.

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

B. K. Park, C. Goldring, M. Searle, 2013, Bone.

MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility.

C. Rubbi, B. K. Park, R. Jenkins, 2011, Carcinogenesis.

N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity.

B. K. Park, M. Tingle, H. Gill, 1995, British journal of clinical pharmacology.

Drug-protein conjugates--VII. Disposition of [3H]-ethinylestradiol-protein conjugates in the rat.

P. Grabowski, B. Park, 1984, Biochemical Pharmacology.

Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

N. Hanley, N. Kitteringham, B. K. Park, 2013, British journal of clinical pharmacology.

Validation of the isolation and quantification of kidney enriched miRNAs for use as biomarkers

B. K. Park, D. Antoine, J. Sharkey, 2012, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Cytochrome P450 enzyme polymorphisms and adverse drug reactions.

Munir Pirmohamed, M. Pirmohamed, B. K. Park, 2003, Toxicology.

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

M. Pirmohamed, A. Marson, B. K. Park, 2020, British journal of clinical pharmacology.

Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study

P. Ghaneh, G. Poston, N. Kitteringham, 2013, Cancer Chemotherapy and Pharmacology.

Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study

M. Pirmohamed, J. Bonventre, T. Farragher, 2012, PloS one.

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01

M. Pirmohamed, A. Lister, B. K. Park, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component

B. K. Park, D. Naisbitt, S. Ward, 1996, Antimicrobial agents and chemotherapy.

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

B. K. Park, S. Ward, P. O’Neill, 1996, Biochemical pharmacology.

Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine.

B. K. Park, S. Ward, P. Bray, 1996, Molecular and biochemical parasitology.

verapamil-sensitive chloroquine resistance amodiaquine to overcome the Manipulation of the N-alkyl substituent in

B. K. Park, D. Naisbitt, P. O’Neill, 1996 .

Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.

B. K. Park, P. O’Neill, J. Maggs, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Drug disposition and drug hypersensitivity.

N. Kitteringham, B. K. Park, J. Coleman, 1987, Biochemical pharmacology.

Drug protein conjugates--I. A study of the covalent binding of [14C]captopril to plasma proteins in the rat.

A. Breckenridge, B. K. Park, P. Grabowski, 1982, Biochemical pharmacology.

Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications.

M. Pirmohamed, G. Tucker, N. Kitteringham, 2003, British journal of clinical pharmacology.

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

Andreas Luch, Thomas Rustemeyer, Andrea Cavani, 2010, Cellular and Molecular Life Sciences.

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

B. K. Park, James Chadwick, P. Stocks, 2010, Bioorganic & medicinal chemistry.

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.

B. K. Park, S. Ward, P. O’Neill, 2002, Journal of medicinal chemistry.

Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues

B. K. Park, S. Ward, P. O’Neill, 2001 .

Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis.

M. Pirmohamed, A. Breckenridge, B. K. Park, 1993, British journal of rheumatology.

Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men.

B. K. Park, R. Vestal, J. Koup, 1988, The Journal of pharmacology and experimental therapeutics.

The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1999, Pharmacogenetics.

Urinary excretion of 6β-hydroxycortisol and the time course measurement of enzyme induction in man

A. Breckenridge, B. K. Park, E. Ohnhaus, 2004, European Journal of Clinical Pharmacology.

Promiscuous T-cell responses to drugs and drug-haptens.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2015, The Journal of allergy and clinical immunology.

Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.

N. Kitteringham, C. Goldring, C. Rowe, 2010, Journal of proteome research.

14. MIST AND THE FUTURE

B. K. Park, Dennis A. Smith, B. Park, 2016 .

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1.

B. K. Park, C. Goldring, D. Naisbitt, 2009, Toxicology and applied pharmacology.

Metabolic Models of Cytotoxicity

M. Pirmohamed, B. K. Park, B. Park, 1999 .

Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation.

B. K. Park, E. Tomlinson, D. Back, 1996, The Journal of pharmacology and experimental therapeutics.

Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.

A. Breckenridge, B. K. Park, M. Coleman, 1989, British journal of clinical pharmacology.

Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity

Dominic P. Williams, H. Laverty, A. Kipar, 2010, Molecular medicine.

Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development

Chris S. Pridgeon, R. Pieters, M. Ingelman-Sundberg, 2017 .

LC determination of carbamazepine in murine brain.

M. Pirmohamed, B. K. Park, A. Owen, 2001, Journal of pharmaceutical and biomedical analysis.

Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements.

M. Pirmohamed, B. K. Park, C. Goldring, 2006, British journal of clinical pharmacology.

Immune drug-induced liver disease and drugs

B. K. Park, D. Naisbitt, X. Meng, 2017, Current Opinion in Toxicology.

Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans.

J. Ashby, B. K. Park, J. Maggs, 2001, The Journal of pharmacology and experimental therapeutics.

Species variation in the bioactivation of tacrine by hepatic microsomes.

B. K. Park, S. Madden, T. Woolf, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Polymorphisms in the TNF‐α and TNF‐receptor genes in patients with coronary artery disease

M. Pirmohamed, B. K. Park, R. Allen, 2001 .

From mice to men: Murine models of colorectal cancer for use in translational research.

Eithne Costello, D. Palmer, N. Kitteringham, 2016, Critical reviews in oncology/hematology.

Costimulatory Signaling Sulfamethoxazole Stimulate Dendritic Cell Sulfamethoxazole and Its Metabolite Nitroso

Charlotte A. Ashby, M. Pirmohamed, M. Rieder, 2007 .

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies

Neal C Burton, Julie Holder, Neal C. Burton, 2017, npj Regenerative Medicine.

Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method.

M. Pirmohamed, I. Wilson, M. Coen, 2014, Bioanalysis.

Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice

Dominic P. Williams, K. Itoh, Masayuki Yamamoto, 2004, Hepatology.

Effect of sodium valproate on carbamazepine disposition and psychomotor profile in man.

B. K. Park, G. Macphee, M. Brodie, 1988, British journal of clinical pharmacology.

Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi*

M. Chamberlain, C. Wolf, N. Kitteringham, 2003, Journal of Biological Chemistry.

Assessing the safety of stem cell therapeutics.

N. Benvenisty, H. Laverty, P. Andrews, 2011, Cell stem cell.

S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility

Eithne Costello, J. Neoptolemos, P. Navarro, 2009, British Journal of Cancer.

MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity

J. Bowes, N. Hanley, J. Sidaway, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

Yongxiang Fang, A. Odermatt, N. Kitteringham, 2015, Kidney international.

FORMATION AND PROTEIN BINDING OF THE ACYL GLUCURONIDE OF A LEUKOTRIENE B4 ANTAGONIST (SB-209247): RELATION TO SPECIES DIFFERENCES IN HEPATOTOXICITY

B. K. Park, J. Maggs, J. Kenny, 2005, Drug Metabolism and Disposition.

Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22–Secreting T Cells and the Influence of PD-1 on Effector T Cell Function

Andrew Gibson, B. K. Park, D. Naisbitt, 2014, The Journal of Immunology.

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis

M. Pirmohamed, B. K. Park, D. Naisbitt, 2012, Journal of Pharmacology and Experimental Therapeutics.

Cell Function Cells and the Influence of PD-1 on Effector T Secreting T − Drug-Specific Priming of IL-22 Negative Regulation by PD-L 1 during

Andrew Gibson, B. K. Park, D. Naisbitt, 2014 .

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes.

B. K. Park, S. Madden, T. Woolf, 1993, Biochemical pharmacology.

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus

D. Tuveson, I. Jacobs, U. Menon, 2015, Clinical Cancer Research.

Determination of human hepatic cytochrome P4501A2 activity in vitro use of tacrine as an isoenzyme-specific probe.

R J Edwards, R. Edwards, D. Davies, 1995, Drug metabolism and disposition: the biological fate of chemicals.

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes.

B. K. Park, S. Madden, T. Woolf, 1994, British journal of clinical pharmacology.

The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials*

B. K. Park, P. O’Neill, J. Maggs, 2010, The Journal of Biological Chemistry.

Stem cell models as an in vitro model for predictive toxicology

B. K. Park, C. Goldring, Parveen Sharma, 2019, The Biochemical journal.

Glutathione S-transferase mu genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1995, British journal of clinical pharmacology.

Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.

J. Parsons, D. Palmer, N. Kitteringham, 2018, Journal of proteomics.

Warfarin: metabolism and mode of action.

B. K. Park, B. Park, 1988, Biochemical pharmacology.

An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1993, Biochemical pharmacology.

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.

Paul J Thornalley, Masayuki Yamamoto, N. Kitteringham, 2012, The Biochemical journal.

Optimising the use of medicines to reduce acute kidney injury in children and babies

B. K. Park, M. Turner, M. Beresford, 2017, Pharmacology & therapeutics.

Are we closer to finding biomarkers for identifying acute drug-induced liver injury?

B. K. Park, C. Goldring, D. Antoine, 2013, Biomarkers in medicine.

A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction

B. K. Park, P. Murray, Lauren Scarfe, 2019, Stem cells international.

Development of an imaging toolbox to assess the therapeutic potential and biodistribution of macrophages in a mouse model of multiple organ dysfunction

B. K. Park, P. Murray, N. Brillant, 2018, bioRxiv.

Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.

C. Davis, B. K. Park, Peter D Gibbons, 2009, Journal of medicinal chemistry.

A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

B. K. Park, G. Biagini, N. Berry, 2006, Current topics in medicinal chemistry.

Ruth H. Hughes, B. K. Park, P. Stocks, 2003, Journal of medicinal chemistry.

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

T. Iwawaki, C. Goldring, S. Forootan, 2017, Scientific Reports.

Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models.

Amy E. Chadwick, B. K. Park, Neil S French, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

Rifampicin and vitamin D metabolism

M. Brodie, A. Boobis, D. Brown, 1980, Clinical pharmacology and therapeutics.

Investigation of the immunogenicity of diclofenac and diclofenac metabolites.

B. K. Park, D. Naisbitt, X. Meng, 2007, Toxicology letters.

α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro

B. K. Park, J. Maggs, D. Boocock, 1999 .

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.

Dominic P. Williams, W. Hillen, C. Berens, 2006, American journal of physiology. Cell physiology.

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients.

M. Pirmohamed, A. Marson, B. K. Park, 2017, Chemical research in toxicology.

Structural basis for the haemotoxicity of dapsone: the importance of the sulphonyl group.

J. Dearden, M. Cronin, B. K. Park, 1997, Toxicology.

The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system

J. Hayes, N. Kitteringham, C. Goldring, 2008, Hepatology.

Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore

Dominic P. Williams, I. Wilson, J. Maggs, 2008, Journal of Pharmacology and Experimental Therapeutics.

Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency

Dominic P. Williams, M. Pirmohamed, A. Breckenridge, 1996, AIDS.

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2013, Chemical research in toxicology.

TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients

M. Pirmohamed, B. K. Park, D. Chadwick, 2001, Neurology.

Lipodystrophy in Patients with HIV-1 Infection: Effect of Stopping Protease Inhibitors on Tnf-α and Tnf-Receptor Levels, and on Metabolic Parameters

M. Pirmohamed, W. Fraser, B. K. Park, 2004, Antiviral therapy.

No association between tacrine transaminitis and the glutathione transferase theta genotype in patients with Alzheimer's disease.

M. Pirmohamed, N. Kitteringham, B. K. Park, 1998, Pharmacogenetics.

University of Dundee Chemical tuning enhances both potency toward Nrf 2 and in vitro therapeutic index of triterpenoids

A. Odermatt, D. Kratschmar, A. Lister, 2014 .

Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

B. K. Park, S. Powell, G. Edwards, 1998, British journal of pharmacology.

The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro.

B. K. Park, S. Ward, G. Edwards, 2001, Biochemical pharmacology.

Erratum: Characterisation of the toxic metabolite(s) of naphthalene (Toxicology 114 (1996) (233)) PII S0300483X96035159

Dominic P. Williams, M. Pirmohamed, C. Davis, 1997 .

Assessment of the drug metabolism capacity of the liver.

B. K. Park, B. Park, 1982, British journal of clinical pharmacology.

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011, The Journal of Immunology.

Drug metabolite-specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis.

D. Naisbitt, D. Peckham, S. Lavergne, 2010, Chemical research in toxicology.

Food , drug , insect sting allergy , and anaphylaxis Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis

D. Naisbitt, W. Pichler, J. Farrell, 2011 .

The metabolism of 2- and 4-fluoro-17 beta-oestradiol in the rat and its implications for oestrogen carcinogenesis.

B. K. Park, J. Maggs, P. Morgan, 1992, Biochemical pharmacology.

Drug-protein conjugates--VIII. The metabolic fate of the dinitrophenyl hapten conjugated to albumin.

N. Kitteringham, B. K. Park, J. Maggs, 1985, Biochemical pharmacology.

Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway.

N. Kitteringham, B. K. Park, C. Goldring, 2007, Life sciences.

TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.

Clive E. Bowman, W. Thomson, M. Pirmohamed, 2009, Pharmacogenomics.

Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men.

B. K. Park, R. Vestal, B. Cusack, 1987, The Journal of pharmacology and experimental therapeutics.

Characterisation of flucloxacillin and 5‐hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo

M. Pirmohamed, N. Kitteringham, B. K. Park, 2009, Proteomics. Clinical applications.

Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.

M. Pirmohamed, W. Rapeport, B. K. Park, 2001, Chemical research in toxicology.

Assessment of urinary 6 beta-hydroxycortisol as an in vivo index of mixed-function oxygenase activity.

B. K. Park, B. Park, 1981, British journal of clinical pharmacology.

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging.

B. K. Park, J. G. Kenna, S. Stahl, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

The importance of hapten–protein complex formation in the development of drug allergy

B. K. Park, D. Naisbitt, L. Faulkner, 2014, Current opinion in allergy and clinical immunology.

Haloarene derivatives of carbamazepine with reduced bioactivation liabilities: 2-monohalo and 2,8-dihalo derivatives.

Dominic P. Williams, B. K. Park, L. Parry, 2012, Journal of medicinal chemistry.

The effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes.

M. Pirmohamed, A. Breckenridge, N. Kitteringham, 1992, Biochemical pharmacology.

An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro.

M. Pirmohamed, A. Breckenridge, N. Kitteringham, 1992, Biochemical pharmacology.

Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation.

B. K. Park, P. O’Neill, J. Maggs, 1999, The Journal of pharmacology and experimental therapeutics.

Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.

Dominic P. Williams, M. Pirmohamed, B. K. Park, 1997, The Journal of pharmacology and experimental therapeutics.

Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity

Amy E. Chadwick, Dominic P. Williams, M. Monshouwer, 2019, Current protocols in toxicology.

Polymorphisms in the TNF-alpha and TNF-receptor genes in patients with coronary artery disease.

M. Pirmohamed, B. K. Park, R. Allen, 2001, European journal of clinical investigation.

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.

M. Pirmohamed, B. K. Park, D. Naisbitt, 2011, The Journal of allergy and clinical immunology.

The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide.

B. K. Park, P. O’Neill, J. Maggs, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling*

L. Djouhri, S. Sethu, N. Kitteringham, 2013, The Journal of Biological Chemistry.

Co(thd)2: a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes

B. K. Park, P. Stocks, S. Ward, 2003 .

Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical.

B. K. Park, S. Ward, P. O’Neill, 2000, The Journal of organic chemistry.

Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene.

M. Pirmohamed, N. Kitteringham, C. Davis, 1996, The Journal of pharmacology and experimental therapeutics.

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.

M. Pirmohamed, D. Grant, B. Burchell, 1995, Biochemical pharmacology.

The pharmacokinetics of levonorgestrel and ethynylestradiol in women - studies with Ovran and Ovranette.

A. Breckenridge, B. K. Park, D. Back, 1981, Contraception.

Oxidative bioactivation of abacavir in subcellular fractions of human antigen presenting cells.

D. Naisbitt, P. O’Neill, J. Maggs, 2013, Chemical research in toxicology.

Enantiomers of warfarin and vitamin K1 metabolism.

A. Breckenridge, B. K. Park, S. Cholerton, 1986, British journal of clinical pharmacology.

Albumin and immunoglobulin depletion of human plasma.

N. Kitteringham, B. K. Park, R. Jenkins, 2008, Methods in molecular biology.

The use of a three compartment in vitro model to investigate the role of hepatic drug metabolism in drug-induced blood dyscrasias.

B. K. Park, M. Tingle, B. Park, 1993, British journal of clinical pharmacology.

New Approaches to Investigate Drug-Induced Hypersensitivity.

M. Pirmohamed, Andrew Gibson, A. Norris, 2017, Chemical research in toxicology.

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

J. Baird, I. Piantanida, B. K. Park, 2009, Bioorganic & medicinal chemistry letters.

Optimal dose identification: predicting a safe dose in man from animal studies

M. Pirmohamed, I. White, N. Kitteringham, 2001 .

Dapsone and Nitroso Dapsone Activation of Naı̈ve T-Cells from Healthy Donors.

D. Naisbitt, M. Ogese, J. Maggs, 2017, Chemical research in toxicology.

Development of a monoclonal antibody to 6β-hydroxycortisol and its application in an enzyme-linked immunosorbent assay (ELISA) for 6β-hydroxycortisol in urine

B. K. Park, J. Yeung, J. Wong, 1997 .

Assessment of enzyme induction and enzyme inhibition in humans: toxicological implications.

N. Kitteringham, B. K. Park, B. Park, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

A method for the rapid depletion of albumin and immunoglobulin from human plasma

M. Pirmohamed, S. Pennington, N. Kitteringham, 2004, Proteomics.

Effect of low-dose phenobarbitone on five indirect indices of hepatic microsomal enzyme induction and plasma lipoproteins in normal subjects.

E. Perucca, D. Betteridge, B. K. Park, 1981, British journal of clinical pharmacology.

Vitamin K1 metabolism in relation to pharmacodynamic response in anticoagulated patients.

A. Breckenridge, B. K. Park, S. Cholerton, 1985, British journal of clinical pharmacology.

Effects of cimetidine on carbamazepine auto- and hetero-induction in man.

B. K. Park, G. Macphee, K. McColl, 1984, British journal of clinical pharmacology.

Interaction between warfarin and propranolol.

A. Breckenridge, B. K. Park, A. Scott, 1984, British journal of clinical pharmacology.

Cimetidine potentiates the anticoagulant effect of warfarin by inhibition of drug metabolism.

A. Breckenridge, B. K. Park, M. Serlin, 1980, Biochemical pharmacology.

Vitamin K1metabolism inrelation topharmacodynamic response inanticoagulated patients

A. Breckenridge, B. K. Park, S. Cholerton, 1985 .

The effect of enzyme induction on diazepam metabolism in man.

B. K. Park, P. Heizmann, E. Ohnhaus, 1979, British journal of clinical pharmacology.

A study of the relationship between the pharmacokinetics and the pharmacodynamics of the 4-hydroxycoumarin anticoagulants warfarin, difenacoum and brodifacoum in the rabbit.

A. Breckenridge, B. K. Park, S. Cholerton, 1985, British journal of pharmacology.

Enzyme induction by phenobarbitone and vitamin K1 disposition in man.

G. Kaatz, B. K. Park, E. Ohnhaus, 1984, British journal of clinical pharmacology.

Hepatic enzyme induction and vitamin K1 elimination in man

B. K. Park, A. Scott, E. Ohnhaus, 2004, European Journal of Clinical Pharmacology.

Therelationship between inhibition ofvitamin K12,3-epoxide reductase andreduction ofclotting factor activity withwarfarin

A. Breckenridge, B. K. Park, C. Hay, 1988 .

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries

Dominic P. Williams, M. Pirmohamed, L. Lian, 2010, Drug Metabolism and Disposition.

Detection and biochemical characterisation of a novel polymorphism in the human GSTP1 gene.

L. Lian, N. Kitteringham, B. K. Park, 2007, Biochimica et biophysica acta.

Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay.

J. Ashby, J. Sumpter, D. Paton, 2001, The Journal of pharmacology and experimental therapeutics.

The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors

M. Pirmohamed, B. K. Park, Andrew Gibson, 2017, The Journal of Immunology.

The effect of rifampicin on norethisterone pharmacokinetics

B. K. Park, D. Back, M. Maciver, 1979, European Journal of Clinical Pharmacology.