A. George

发表

Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome.

C. Sanders, A. George, C. Tian, 2007, Biochemistry.

Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels

A. George, Dao-wu Wang, A. Mistry, 2010, Front. Pharmacol..

Malignant Perinatal Variant of Long-QT Syndrome Caused by a Profoundly Dysfunctional Cardiac Sodium Channel

P. Schwartz, W. Shimizu, T. Ikeda, 2008, Circulation. Arrhythmia and electrophysiology.

Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy.

Carlos G Vanoye, Alfred L George, A. George, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A).

A. George, Dao-wu Wang, T. Knilans, 2003, The Journal of clinical investigation.

Inherited disorders of voltage-gated sodium channels.

Alfred L George, A. George, A. George, 2005, The Journal of clinical investigation.

KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes.

Carlos G Vanoye, Alfred L George, G. Andelfinger, 2002, American journal of human genetics.

Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT

X. Estivill, D. Torrents, G. Borsani, 1999, Nature Genetics.

Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia.

R. Wakai, A. George, B. Cuneo, 2012, Heart rhythm.

Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel ß1 subunit gene SCN1B

Samuel F. Berkovic, Ingrid E. Scheffer, Robyn H. Wallace, 1998, Nature Genetics.

Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation

Hannah A. Ledford, V. Yarov-Yarovoy, A. George, 2020, The Journal of general physiology.

SCN5A allelic expression imbalance in African-Americans heterozygous for the common variant p.Ser1103Tyr

M. Ackerman, A. George, Lily Wang, 2010, BMC Medical Genetics.

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA‐B Genotype and Carbamazepine Dosing

J. Kelsoe, M. Whirl‐Carrillo, M. Pirmohamed, 2012, Clinical pharmacology and therapeutics.

Transcriptional Networks in Epithelial-Mesenchymal Transition

Terri T. Ni, A. George, E. Neilson, 2011, PloS one.

Novel Calmodulin Mutations Associated With Congenital Arrhythmia Susceptibility

Takeshi Tsuchiya, Thomas Meitinger, Tatsuhiko Tsunoda, 2014, Circulation. Cardiovascular genetics.

Mechanism of voltage-dependent gating in skeletal muscle chloride channels.

A. George, A. Rosenbohm, C. Fahlke, 1996, Biophysical journal.

An aspartic acid residue important for voltage-dependent gating of human muscle chloride channels

A. George, C. Fahlke, Ming Zhou, 1995, Neuron.

Pore stoichiometry of a voltage-gated chloride channel

A. George, C. Fahlke, T. H. Rhodes, 1998, Nature.

Calmodulin Mutations Associated With Recurrent Cardiac Arrest in Infants

Thomas Meitinger, Peter J. Schwartz, Walter J. Chazin, 2013, Circulation.

PiggyBac transposon-mediated gene transfer in human cells.

Alfred L George, A. George, C. Coates, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

A KCNH2 branch point mutation causing aberrant splicing contributes to an explanation of genotype-negative long QT syndrome.

P. Schwartz, A. George, F. Pagani, 2009, Heart rhythm.

High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot.

M. Meisler, A. George, M. Trudeau, 2003, Genomics.

Mitochondrial cardiomyopathy and ventricular arrhythmias associated with biallelic variants in C1QBP

Nicoleta C. Arva, A. George, N. Arva, 2021, American journal of medical genetics. Part A.

Use of Contemporary Genetics in Cardiovascular Diagnosis

A. George, A. George, 2014, Circulation.

Impact of genetics on the clinical management of channelopathies.

Michael J Ackerman, Arthur A M Wilde, Alfred L George, 2013, Journal of the American College of Cardiology.

Impact of Genetics on the ClinicalManagementof Channelopathies

P. Schwartz, A. Wilde, M. Ackerman, 2019 .

Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16

S. Heath, G. Lathrop, M. Farrall, 2013, Nature Genetics.

Cardiac ion channels.

Mark E. Anderson, D. Roden, J. Balser, 2002, Annual review of physiology.

Prevalence of Abnormal Heart Weight After Sudden Death in People Younger than 40 Years of Age

Lauren C. Balmert, A. George, E. McNally, 2020, Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.

Y. Shyr, A. George, B. Lehmann, 2013, PloS one.

Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy.

A. George, V. Murday, K. McLeod, 2014, Heart rhythm.

Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro

D. Roden, L. Harris, A. George, 2011, Circulation.

Divergent Biophysical Defects Caused by Mutant Sodium Channels in Dilated Cardiomyopathy With Arrhythmia

A. George, Daowen Wang, T. H. Rhodes, 2008, Circulation research.

Cardiac Sodium Channel Dysfunction in Sudden Infant Death Syndrome

P. Schwartz, A. George, M. Pedrazzini, 2007, Circulation.

Genetic Mosaicism in Calmodulinopathy.

Christopher N. Johnson, G. Carvill, J. Al-Aama, 2019, Circulation. Genomic and precision medicine.

Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome.

Yan Guo, Yu Shyr, Dan M Roden, 2014, Journal of the American College of Cardiology.

Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes

R. Altman, Yufeng Shen, Yusuke Nakamura, 2013, PloS one.

A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes

Marylyn D. Ritchie, Thomas Meitinger, Dana C. Crawford, 2012, Circulation. Cardiovascular genetics.

Allelic Variants in Long-QT Disease Genes in Patients With Drug-Associated Torsades de Pointes

P. C. Viswanathan, S. Hohnloser, K. Murray, 2002, Circulation.

Inherited Arrhythmias: A National Heart, Lung, and Blood Institute and Office of Rare Diseases Workshop Consensus Report About the Diagnosis, Phenotyping, Molecular Mechanisms, and Therapeutic Approaches for Primary Cardiomyopathies of Gene Mutations Affecting Ion Channel Function

Michael J Ackerman, Colleen E Clancy, Stephan E Lehnart, 2007, Circulation.

Recent genetic discoveries implicating ion channels in human cardiovascular diseases.

A. George, A. George, 2014, Current opinion in pharmacology.

Recent Advances in Understanding the Molecular Mechanisms of the Long QT Syndrome

D. Roden, A. George, P. Bennett, 1995, Journal of cardiovascular electrophysiology.

Cardiac Sodium Channel (SCN5A) Variants Associated with Atrial Fibrillation

J. Haines, D. Roden, P. Kannankeril, 2008, Circulation.

Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart

C. D. dos Remedios, A. George, P. Moerland, 2014, PloS one.

Selective Targeting of Gain-of-Function KCNQ1 Mutations Predisposing to Atrial Fibrillation

Christopher H. Thompson, A. George, D. Darbar, 2013, Circulation. Arrhythmia and electrophysiology.

Expression and transcriptional control of human KCNE genes.

A. George, Andrew L. Lundquist, L. Ballester, 2006, Genomics.

Prevalence of Long-QT Syndrome Gene Variants in Sudden Infant Death Syndrome

Peter J. Schwartz, Alfred L. George, Lia Crotti, 2007, Circulation.

Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry.

E. Behr, P. Schwartz, G. Parati, 2019, European heart journal.

Modifier genes for sudden cardiac death

P. Schwartz, A. George, L. Crotti, 2018, European heart journal.

AKAP9 Is a Genetic Modifier of Congenital Long-QT Syndrome Type 1

P. Schwartz, J. Moolman-Smook, P. Brink, 2014, Circulation. Cardiovascular genetics.

Identification of a KCNQ1 Polymorphism Acting as a Protective Modifier Against Arrhythmic Risk in Long-QT Syndrome

P. Schwartz, D. Trégouët, W. Shimizu, 2013, Circulation. Cardiovascular genetics.

NOS1AP Is a Genetic Modifier of the Long-QT Syndrome

P. Schwartz, P. Brink, A. George, 2009, Circulation.

KCNH2-K897T Is a Genetic Modifier of Latent Congenital Long-QT Syndrome

Dan M Roden, Alessandro Vicentini, Lia Crotti, 2005, Circulation.

Erratum: The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum (Nature Genetics (2002) 32(384-392))

J. Bouchard, A. George, G. Rouleau, 2002 .

KNa1.1 gain-of-function preferentially dampens excitability of murine parvalbumin-positive interneurons

Tracy S. Gertler, A. George, Suraj Cherian, 2022, Neurobiology of Disease.

Vagal reflexes following an exercise stress test: a simple clinical tool for gene-specific risk stratification in the long QT syndrome.

P. Schwartz, M. L. La Rovere, P. Brink, 2012, Journal of the American College of Cardiology.

Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome.

P. Schwartz, M. L. La Rovere, P. Brink, 2008, Journal of the American College of Cardiology.

The genetic basis of variability in drug responses

D. Roden, A. George, A. George, 2002, Nature Reviews Drug Discovery.

Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties.

A. George, D. Conte Camerino, Andrew L. Lundquist, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance

Jens Meiler, Bian Li, Jeffrey D Blume, 2017, Circulation. Cardiovascular genetics.

Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome

C. Sanders, J. Meiler, A. George, 2020, Frontiers in Pharmacology.

Upgraded molecular models of the human KCNQ1 potassium channel

C. Sanders, J. Meiler, A. George, 2019, bioRxiv.

Protein structure aids predicting functional perturbation of missense variants in SCN5A and KCNQ1

Jeffrey L. Mendenhall, C. Sanders, D. Roden, 2019, Computational and structural biotechnology journal.

High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance

Jens Meiler, Carlos G. Vanoye, Reshma R. Desai, 2018, Circulation. Genomic and precision medicine.

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations

C. Sanders, J. Meiler, A. George, 2017, Science Advances.

Long QT syndrome-associated mutations in intrauterine fetal death.

Michael J Ackerman, Brian Brost, Alice Ghidoni, 2013, JAMA.

Structural models for the KCNQ1 voltage-gated potassium channel.

C. Sanders, J. Meiler, A. George, 2007, Biochemistry.

Human sodium channel gating defects caused by missense mutations in S6 segments associated with myotonia: S804F and V1293I

S. Cannon, A. George, D. S. Green, 1998, The Journal of physiology.

Functional expression of the Ile693Thr Na+ channel mutation associated with paramyotonia congenita in a human cell line

A. George, B. Fontaine, N. Tabti, 1998, The Journal of physiology.

Mutations in the human skeletal muscle chloride channel gene (CLCN1) associated with dominant and recessive myotonia congenita

J Zhang, R. Griggs, A. George, 1996, Neurology.

Molecular basis of Thomsen's disease (autosomal dominant myotonia congenita)

M. Crackower, G. Ebers, A. George, 1993, Nature Genetics.

Common genetic variants in sudden cardiac death.

A. George, A. George, 2009, Heart rhythm.

CLCNKB-T481S and essential hypertension in a Ghanaian population

Scott M. Williams, Niloufar B. Gillani, A. George, 2009, Journal of hypertension.

Mutations in Kir2.1 Cause the Developmental and Episodic Electrical Phenotypes of Andersen's Syndrome

S. Subramony, S. Bendahhou, A. George, 2001, Cell.

SCN5A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study

Dan M Roden, Dana C Crawford, Kristin Brown-Gentry, 2011, Circulation. Cardiovascular genetics.

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update

M. Whirl‐Carrillo, T. Klein, B. Carleton, 2018, Clinical pharmacology and therapeutics.

Molecular and genetic basis of sudden cardiac death.

Alfred L George, A. George, A. George, 2013, The Journal of clinical investigation.

Novel SCN3A variants associated with focal epilepsy in children

A. George, K. Holland, C. Gurnett, 2014, Neurobiology of Disease.

Trafficking‐competent and trafficking‐defective KCNJ2 mutations in Andersen syndrome

Carlos G Vanoye, Alfred L George, B. Wong, 2006, Human mutation.

Molecular basis of inherited epilepsy.

Alfred L George, A. George, A. George, 2004, Archives of neurology.

Cholesterol-induced suppression of Kir2 channels is mediated by decoupling at the inter-subunit interfaces

Sang Joon Ahn, A. George, B. Akpa, 2022, iScience.

Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state‐dependent block

A. George, J. Desaphy, D. Camerino, 2004, The Journal of physiology.

Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice.

A. George, M. Madaio, E. Neilson, 2004, Kidney international.

Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC‐1 channel regulation and expression

A. De Luca, A. Liantonio, S. Pierno, 2009, British journal of pharmacology.

Cardiac Na+ Channel Dysfunction in Brugada Syndrome Is Aggravated by β1-Subunit

A. George, N. Makita, A. Kitabatake, 2000 .

Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes

Stefano Severi, Antonio Zaza, Alberto Porta, 2017, Cardiovascular research.

CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice

Christopher H. Thompson, C. H. Thompson, A. George, 2017, Proceedings of the National Academy of Sciences.

Lessons learned from genetic testing for channelopathies

A. George, 2014, The Lancet Neurology.

Identification of a mutation in the gene causing hyperkalemic periodic paralysis

Margaret Robertson, Robert L. Barchi, Robert C. Griggs, 1991, Cell.

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.

Dan M Roden, Harold Snieder, Vanessa Marshall, 2012, Journal of the American College of Cardiology.

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice

Christopher H. Thompson, A. George, A. Mistry, 2014, Neurobiology of Disease.

Neuronal modeling of alternating hemiplegia of childhood reveals transcriptional compensation and replicates a trigger-induced phenotype

J. P. Snow, A. George, K. Swoboda, 2020, Neurobiology of Disease.

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

Christopher H. Thompson, C. H. Thompson, E. Kiskinis, 2018, Neurobiology of Disease.

Research conference summary from the 2014 International Task Force on ATP1A3-Related Disorders

Frederick Andermann, Masayuki Sasaki, Allison Brashear, 2017, Neurology: Genetics.

Electrocardiographic Features in Andersen-Tawil Syndrome Patients With KCNJ2 Mutations: Characteristic T-U–Wave Patterns Predict the KCNJ2 Genotype

P. Schwartz, M. Ackerman, G. Vincent, 2005, Circulation.

CLH-3, a ClC-2 anion channel ortholog activated during meiotic maturation in C. elegans oocytes

L. Bianchi, A. George, R. Morrison, 2001, Current Biology.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

E. Petretto, F. Cambien, Y. Pinto, 2017, Genome Biology.

Factor V Leiden Protects Against Blood Loss and Transfusion After Cardiac Surgery

A. George, M. Higgins, B. Donahue, 2003, Circulation.

Potentiating α2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet Syndrome

A. George, A. Contractor, Toshihiro Nomura, 2018, bioRxiv.

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy

Tracy S. Gertler, A. George, L. Laux, 2017, Annals of clinical and translational neurology.

Apolipoprotein l1 and the genetic basis for racial disparity in chronic kidney disease.

A. George, S. Quaggin, A. George, 2011, Journal of the American Society of Nephrology : JASN.

Apolipoprotein L 1 and the Genetic Basis for Racial Disparity in Chronic Kidney Disease

A. George, S. Quaggin, A. George, 2011 .

Mink Subdomains That Mediate Modulation of and Association with Kvlqt1

A. George, A. Tapper, A. George, 2000, The Journal of general physiology.

GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

A. George, P. Burridge, D. Egecioglu, 2020, Molecular Pharmacology.

Molecular cloning of a human, hemicholinium-3-sensitive choline transporter.

R. Blakely, S. Apparsundaram, A. George, 2000, Biochemical and biophysical research communications.

Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias.

Dan M Roden, Dana C Crawford, William S Bush, 2009, Pharmacogenomics.

Progress in Understanding and Treating SCN2A-Mediated Disorders

Stephan J Sanders, D. Malhotra, W. Chung, 2018, Trends in Neurosciences.

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Christopher H. Thompson, J. Kearney, L. Anderson, 2017, Scientific Reports.

Antiepileptic activity of preferential inhibitors of persistent sodium current

Christopher H. Thompson, W. Frankel, A. George, 2014, Epilepsia.

Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytes.

Lia Crotti, Christopher N. Johnson, Nicole Sekarski, 2016, Heart rhythm.

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.

R. Coffey, A. George, Guan-qing Wu, 2008, Journal of the American Society of Nephrology : JASN.

Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women.

R. Kim, A. George, G. Gervasini, 2003, Pharmacogenetics.

Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant

J. Trimmer, A. George, Sunita N. Misra, 2020, Neurobiology of Disease.

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.

D. Roden, A. George, P. Weeke, 2014, Cardiovascular research.

Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation

Ming Zhou, Mohamed Chahine, Richard Horn, 1994, Neuron.

Human sodium channel myotonia: slowed channel inactivation due to substitutions for a glycine within the III‐IV linker.

H. Lerche, N. Mitrović, T. Weiss, 1993, The Journal of physiology.

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

R Horn, M E Gellens, R. Horn, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita

M. Leppert, R. Griggs, M. Robertson, 1992, Neuron.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity

Alfred L George, E. Kaufman, A. George, 2018, The Journal of clinical investigation.

Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels

R. Horn, A. George, N. Yang, 1996, Neuron.

Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility

A. George, C. Gurnett, J. Kearney, 2011, Proceedings of the National Academy of Sciences.

Clinical, Genetic, and Biophysical Characterization of SCN5A Mutations Associated With Atrioventricular Conduction Block

P. C. Viswanathan, J. Balser, A. George, 2002, Circulation.

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse.

A. George, A. De Luca, A. Liantonio, 2002, Brain : a journal of neurology.

Skeletal muscle disuse induces fibre type-dependent enhancement of Na(+) channel expression.

A. George, A. De Luca, S. Pierno, 2001, Brain : a journal of neurology.

Impact of CYP2C9‐Interacting Drugs on Warfarin Pharmacogenomics

J. Pacheco, A. George, Maureen E. Smith, 2020, Clinical and translational science.

Functional analysis of mutations in SLC7A9, and genotype-phenotype correlation in non-Type I cystinuria.

X. Estivill, G. Borsani, A. Ballabio, 2001, Human molecular genetics.

A common polymorphism associated with antibiotic-induced cardiac arrhythmia.

D M Roden, K. Murray, S. Priori, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Epilepsy-Associated Dysfunction in the Voltage-Gated Neuronal Sodium Channel SCN1A

O. Devinsky, A. George, Daowen Wang, 2003, The Journal of Neuroscience.

Molecular mechanism for an inherited cardiac arrhythmia

A. George, N. Makita, P. Bennett, 1995, Nature.

Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21.

D C Ward, D. Ward, H. Drabkin, 1995, Cytogenetics and cell genetics.

The K–Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum

J. Bouchard, A. George, G. Rouleau, 2002, Nature Genetics.

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function.

Christopher N. Johnson, Jonathan P. Davis, R. Pattanayek, 2019, Cell calcium.

Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks).

Carlos G Vanoye, Alfred L George, K. Murray, 2005, Journal of molecular and cellular cardiology.

Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome.

A. George, Dao-wu Wang, P. Bennett, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Strategy for encoding and comparison of gene expression signatures

Chun Li, Yajun Yi, Alfred L George, 2007, Genome Biology.

Coupled analysis of gene expression and chromosomal location.

Yu Shyr, Yajun Yi, Alfred L George, 2005, Genomics.

Inherited Channelopathies Associated with Epilepsy

A. George, A. George, 2004, Epilepsy currents.

KCNE4 Juxtamembrane Region Is Required for Interaction with Calmodulin and for Functional Suppression of KCNQ1*

A. George, R. Welch, C. Vanoye, 2010, The Journal of Biological Chemistry.

Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits

C. Sanders, R. Welch, A. Tapper, 2009, The Journal of general physiology.

Azithromycin Causes a Novel Proarrhythmic Syndrome

Wei Zhang, K. Murray, D. Roden, 2017, Circulation: Arrhythmia and Electrophysiology.

Functional BSND variants in essential hypertension.

Scott M. Williams, Niloufar B. Gillani, A. George, 2007, American journal of hypertension.

Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity.

Wesley L. McKeithan, J. Cashman, K. Sampson, 2020, Cell stem cell.

Genomic organization of a human cystine transporter gene (SLC3A1) and identification of novel mutations causing cystinuria.

A. George, K. Hruska, J. Phillips, 1997, Kidney international.

Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes.

K. Murray, A. George, J. Yi, 2000, Circulation research.

Oocytes Xenopus Channel in Activation of Protein Kinase A Modulates Trafficking of the Human Cardiac Sodium

K. Murray, A. George, J. Yi, 2000 .

Arrhythmia / Electrophysiology Striking In Vivo Phenotype of a Disease-Associated Human SCN 5 A Mutation Producing Minimal Changes in Vitro

D. Roden, L. Harris, A. George, 2011 .

Voltage-dependent regulation of modal gating in the rat SkM1 sodium channel expressed in Xenopus oocytes

R. Horn, A. George, W. Sun, 1994, The Journal of general physiology.

Expression of the sodium channel β 1 subunit in rat skeletal muscle is selectively associated with the tetrodotoxin-sensitive α subunit isoform

A. George, N. Makita, P. Bennett, 1993, Neuron.

Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene.

A. George, N. Makita, P. Bennett, 1994, The Journal of biological chemistry.

Spectrum of KV2.1 Dysfunction in KCNB1‐Associated Neurodevelopmental Disorders

Ethan M. Goldberg, Katarina L. Fabre, Robert P. Carson, 2019, Annals of neurology.

Genetics of kidney disease.

A. George, E. Neilson, A. George, 2000, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Web-based interrogation of gene expression signatures using EXALT

Jian Yu, Jun Wu, Shyr Yu, 2009, BMC Bioinformatics.

Functional repair of a mutant chloride channel using a trans-splicing ribozyme.

B. Sullenger, C. Rogers, C. Vanoye, 2002, The Journal of clinical investigation.

A novel muscle sodium channel mutation causes painful congenital myotonia

A. George, J. Rosenfeld, K. Sloan-Brown, 1997, Annals of neurology.

Subunit Stoichiometry of Human Muscle Chloride Channels

K. Campbell, A. George, C. Fahlke, 1997, The Journal of general physiology.

Masseter Muscle Rigidity Associated with Glycine1306-to- Alanine Mutation in the Adult Muscle Sodium Channel α-Subunit Gene

A. George, A. Olckers, A. Jedlicka, 1995 .

Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro.

R Horn, M. Zhou, R. Horn, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Nonsense and missense mutations of the muscle chloride channel gene in patients with myotonia congenita.

G. Fenichel, A. George, G. Mitchell, 1994, Human molecular genetics.

Pore-forming segments in voltage-gated chloride channels

A. George, C. Fahlke, C. L. Beck, 1997, Nature.

Phenotypic Variability and Unusual Clinical Severity of Congenital Long-QT Syndrome in a Founder Population

D. Roden, P. Schwartz, P. Brink, 2005, Circulation.

Pharmacological targeting of long QT mutant sodium channels.

A. George, N. Makita, Dao-wu Wang, 1997, The Journal of clinical investigation.

The cardiac ion channels: relevance to management of arrhythmias.

D. Roden, A. George, A. George, 1996, Annual review of medicine.

Probing the outer vestibule of a sodium channel voltage sensor.

R. Horn, A. George, N. Yang, 1997, Biophysical journal.

Sudden cardiac death, genes, and arrhythmogenesis: consideration of new population and mechanistic approaches from a National Heart, Lung, and Blood Institute workshop, Part II.

R. Elston, C. Albert, E. Benjamin, 2001, Circulation.

AKAP 9 is a Genetic Modifier of Congenital Long-QT Syndrome Type 1 Running title

P. Schwartz, J. Moolman-Smook, P. Brink, 2014 .

Hereditary dysfunction of voltage-gated sodium channels: from clinical phenotype to molecular mechanisms.

A. George, A. George, 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Pharmacogenomics in pregnancy.

A. George, Hannah K. Betcher, A. George, 2020, Seminars in perinatology.

Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus.

I. Scheffer, S. Berkovic, D. Lev, 2001, American journal of human genetics.

Cardiac potassium channel dysfunction in sudden infant death syndrome.

Dan M Roden, Carlos G Vanoye, Lia Crotti, 2007, Journal of molecular and cellular cardiology.

50 – Mechanisms in Heritable Sodium Channel Diseases

A. George, T. Nguyen, A. George, 2018 .

Mechanisms in Heritable Sodium Channel Diseases

A. George, A. George, 2013 .

A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study

Janina M. Jeff, D. Roden, D. Crawford, 2011 .

SCN 5 A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study

Janina M. Jeff, D. Roden, D. Crawford, 2011 .

Divergent sodium channel defects in familial hemiplegic migraine

M. Ferrari, M. Dichgans, A. George, 2008, Proceedings of the National Academy of Sciences.

Molecular Basis of an Inherited Epilepsy

A. George, Daowen Wang, Christoph Lossin, 2002, Neuron.

Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.

A. George, N. Vázquez, D. Mount, 2002, Brain research. Molecular brain research.

The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome.

E. Behr, D. Roden, P. Schwartz, 2008, The Journal of clinical investigation.

Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

Donald M Bers, Hyun Seok Hwang, Kafa Walweel, 2014, Circulation research.

Nav1.1 dysfunction in genetic epilepsy with febrile seizures‐plus or Dravet syndrome

Alfred L George, H. Stroink, A. George, 2011, The European journal of neuroscience.

Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice

Christopher H. Thompson, K. Bender, A. George, 2021, bioRxiv.

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

Christopher H. Thompson, K. Bender, A. George, 2020, The Journal of general physiology.

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.

R. Coronel, J. D. de Bakker, C. D. dos Remedios, 2014, Journal of the American College of Cardiology.

Functional zinc finger/sleeping beauty transposase chimeras exhibit attenuated overproduction inhibition

A. George, Matthew H. Wilson, J. Kaminski, 2005, FEBS letters.

New approaches to antiarrhythmic therapy: emerging therapeutic applications of the cell biology of cardiac arrhythmias(1).

J. Camm, C. January, D. Roden, 2001, Cardiovascular research.

Functional evaluation of human ion channel variants using automated electrophysiology.

Christopher H. Thompson, Jean-Marc DeKeyser, Leah J Welty, 2021, Methods in enzymology.

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Christopher N. Johnson, W. Chazin, A. George, 2018, Structure.

A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel.

A. George, C. Fahlke, C. L. Beck, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity.

J. Haines, M. Ritchie, R. Kim, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study.

M. Hirsch, T. Merigan, R. Shafer, 2005, The Journal of infectious diseases.

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.

P. Munroe, E. Behr, D. Roden, 2012, Journal of the American College of Cardiology.

Novel Rare Variants in Congenital Cardiac Arrhythmia Genes are Frequent in Drug-induced Torsades de Pointes

M. Rieder, D. Nickerson, D. Roden, 2012, The Pharmacogenomics Journal.

Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro

D. Roden, L. Harris, M. Magnuson, 2011, Circulation.

Cardiac Sodium Channel (SCN5A) Variants Associated with Atrial Fibrillation

D. Roden, P. Kannankeril, D. Darbar, 2008, Circulation.

Personalized Biochemistry and Biophysics

C. Sanders, J. Meiler, A. George, 2015, Biochemistry.

Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

C. Sanders, J. Meiler, A. George, 2020, eLife.

Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

E. Kiskinis, A. George, P. Penzes, 2021, eLife.

A missense mutation in canine ClC‐1 causes recessive myotonia congenita in the dog 1

C. Vite, A. George, C. Fahlke, 1999, FEBS letters.

Voltage Sensors in Domains III and IV, but Not I and II, Are Immobilized by Na+ Channel Fast Inactivation

Francisco Bezanilla, Alfred L George, F. Bezanilla, 1999, Neuron.

Defective fast inactivation recovery and deactivation account for sodium channel myotonia in the I1160V mutant.

P. Ruben, D. Featherstone, A. George, 1997, Biophysical journal.

Enhanced Na(+) channel intermediate inactivation in Brugada syndrome.

J. Balser, A. George, N. Makita, 2000, Circulation research.

Functional effects of protein kinase C activation on the human cardiac Na+ channel.

K. Murray, A. George, Hyeon-Gyu Shin, 1997, Circulation research.

Gating-Dependent Mechanisms for Flecainide Action in SCN5A-Linked Arrhythmia Syndromes

P. C. Viswanathan, D. Roden, J. Balser, 2001, Circulation.

Functional consequences of a domain 1/S6 segment sodium channel mutation associated with painful congenital myotonia

P. Ruben, A. George, Dao-wu Wang, 1999, FEBS letters.

The E 1784 K mutation in SCN 5 A is associated with mixed clinical phenotype of type 3 long QT syndrome

E. Behr, D. Roden, P. Schwartz, 2008 .

Sudden cardiac death, genes, and arrhythmogenesis : consideration of new population and mechanistic approaches from a national heart, lung, and blood institute workshop, part I.

R. Elston, C. Albert, E. Benjamin, 2001, Circulation.

Cardiac Na(+) channel dysfunction in Brugada syndrome is aggravated by beta(1)-subunit.

A. George, N. Makita, Dao-wu Wang, 2000, Circulation.

Congenital long QT syndrome aggravated by salt-wasting nephropathy.

A. George, D. Darbar, F. Fish, 2005, Heart rhythm.

Multiscale Complexity Analysis of the Cardiac Control Identifies Asymptomatic and Symptomatic Patients in Long QT Syndrome Type 1

Pere Caminal, Sergio Cerutti, Alberto Porta, 2014, PloS one.

New approaches to establish genetic causality.

A. George, E. McNally, A. George, 2015, Trends in cardiovascular medicine.

Molecular determinants of state‐dependent block of voltage‐gated sodium channels by pilsicainide

A. George, G. Lentini, C. Franchini, 2010, British journal of pharmacology.

Reply: Familial Hypercholesterolemia Causes Sudden Death.

Lauren C. Balmert, L. Balmert, G. Webster, 2019, Journal of the American College of Cardiology.

Cloning and Characterization of KCC3 and KCC4, New Members of the Cation-Chloride Cotransporter Gene Family*

A. George, E. Delpire, D. Mount, 1999, The Journal of Biological Chemistry.

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.

Rosy Joshi-Mukherjee, Alfred L George, M. Overgaard, 2014, Journal of molecular and cellular cardiology.

Extracellular Sodium Interacts with the HERG Channel at an Outer Pore Site

Reshma R. Desai, Alfred L. George, Jeffrey R. Balser, 2002, The Journal of general physiology.

Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine.

D. Surmeier, W. Shen, A. George, 2020, The Journal of clinical investigation.

Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca2+ Regulation by Distinct Mechanisms

Peter J. Schwartz, Alfred L. George, Lia Crotti, 2014, Journal of the American Heart Association.

Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria

Christopher H. Thompson, C. H. Thompson, A. George, 2020, bioRxiv.

Molecular basis of inherited epilepsy.

A. George, 2004, Archives of neurology.

Appraising the value of genomic association studies.

A. George, A. George, 2008, Journal of the American Society of Nephrology : JASN.

Treatment of calmodulinopathy with verapamil

A. George, G. Webster, Zachary J. Schoppen, 2017, BMJ Case Reports.

Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytes.

Christopher N. Johnson, W. Chazin, L. Crotti, 2016, Heart rhythm.

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.

Wen-Chin Tsai, M. Rubart, Peng-Sheng Chen, 2016, Heart rhythm.

Calmodulinopathy: a genetic trilogy.

A. George, A. George, 2015, Heart rhythm.

Divergent Regulation of Ryr2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

D. Bers, W. Chazin, A. George, 2014 .

Novel Calmodulin (CALM2) Mutations Associated with Congenital Arrhythmia Susceptibility

Christopher N. Johnson, Toshihiro Tanaka, T. Tsunoda, 2022 .

Nav1.1 dysfunction in genetic epilepsy with febrile seizures‐plus or Dravet syndrome

H. Stroink, D. Lindhout, B. Koeleman, 2011, The European journal of neuroscience.

Impaired Inactivation Gate Stabilization Predicts Increased Persistent Current for an Epilepsy-Associated SCN1A Mutation

Alfred L. George, Kristopher M. Kahlig, Sunita N. Misra, 2006, The Journal of Neuroscience.

Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation

J. L. Haines, J. Sutcliffe, J. Haines, 2001, Neurology.

Role of Domain 4 in Sodium Channel Slow Inactivation

R. Horn, A. George, N. Mitrović, 2000, The Journal of general physiology.

Independent Versus Coupled Inactivation in Sodium Channels

R. Horn, A. George, N. Mitrović, 1998, The Journal of general physiology.

In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.

Dan M Roden, Ping Yang, Alfred L George, 2004, Proceedings of the National Academy of Sciences of the United States of America.

IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines

D. Roden, J. Balser, A. George, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

NOS1AP Is a Genetic Modifier of the Long-QT Syndrome

P. Schwartz, P. Brink, L. Crotti, 2009, Circulation.

Allelic Complexity in Long QT Syndrome: A Family-Case Study

A. George, N. Detta, F. Salvatore, 2017, International journal of molecular sciences.

Arrhythmic Risk in Long-QT Syndrome Polymorphism Acting as a Protective Modifier Against KCNQ 1 Identification of a

P. Schwartz, D. Trégouët, W. Shimizu, 2013 .

Measuring Drug Metabolism Kinetics and Drug-Drug Interactions Using Self-Assembled Monolayers for Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry.

A. George, M. Mrksich, Eric J. Berns, 2016, Analytical chemistry.

Abstract 12560: Targeted Next Generation Exomic Sequencing of Cardiac Electrophysiology Genes in Cases of Drug-Induced Torsades de Pointes

D. Roden, S. Levy, A. Ramirez, 2010 .

Congenital long-QT syndrome caused by a novel mutation in a conserved acidic domain of the cardiac Na+ channel.

D M Roden, D. Roden, A. George, 1999, Circulation.

The K–Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum

J. Bouchard, A. George, G. Rouleau, 2002, Nature Genetics.

Misplaced brain sodium channels in heart kindle sudden death in epilepsy.

A. George, A. George, 2015, Circulation. Arrhythmia and electrophysiology.

Myotonic dystrophy kinase modulates skeletal muscle but not cardiac voltage‐gated sodium channels

M. Chahine, A. George, 1997, FEBS letters.

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.

R. Coffey, Guan-qing Wu, Zhong-Ping Feng, 2008, Journal of the American Society of Nephrology : JASN.

Nadolol Block of Nav1.5 Does Not Explain Its Efficacy in the Long QT Syndrome

P. Schwartz, A. George, Dao-wu Wang, 2012, Journal of cardiovascular pharmacology.

Mechanism of Ion Permeation in Skeletal Muscle Chloride Channels

A. George, C. Fahlke, Christine Dürr, 1997, The Journal of general physiology.

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Christopher H. Thompson, C. H. Thompson, A. George, 2017, Scientific Reports.

Use-Dependent Block of Human Cardiac Sodium Channels by GS967

A. George, C. Vanoye, F. Potet, 2016, Molecular Pharmacology.

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update

M. Whirl‐Carrillo, T. Klein, B. Carleton, 2018, Clinical pharmacology and therapeutics.

Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-à-go-go-related Gene (hERG)-related Drug-induced Arrhythmias*

J. Balser, C. Lindsley, Beiyan Zou, 2012, The Journal of Biological Chemistry.

Protein Kinase A Phosphorylation Alters Kvβ1.3 Subunit-mediated Inactivation of the Kv1.5 Potassium Channel*

K. Murray, A. George, M. Tamkun, 1999, The Journal of Biological Chemistry.

Association of a common KCNE1 variant with heart failure.

A. George, A. George, 2010, Heart rhythm.

Genomic organization of the human skeletal muscle sodium channel gene.

A. George, R. Kallen, R L Barchi, 1993, Genomics.

Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine

M. Bellis, A. George, P. Delmas, 2009, PAIN®.

Novel SCN1A frameshift mutation with absence of truncated NaV1.1 protein in severe myoclonic epilepsy of infancy

A. George, Jennifer D. Kunic, J. Kunic, 2008, American journal of medical genetics. Part A.

Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal‐infantile seizures

Kristopher M. Kahlig, Sunita N. Misra, A. George, 2008, Epilepsia.

Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic–clonic seizures

K. Yamakawa, A. George, I. Ohmori, 2005, The Journal of physiology.

Epilepsy and neurobehavioral abnormalities in mice with a KCNB1 pathogenic variant that alters conducting and non-conducting functions of KV2.1

J. Trimmer, A. George, Sunita N. Misra, 2019, bioRxiv.

Chromosome 17 Candidate Gene Analysis in a Population Referred Because of Suspected Susceptibility to Malignant Hyperthermia

A. George, A. Olckers, A. Jedlicka, 1996 .

Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels.

K. Murray, K. Wells, A. George, 2012, American journal of physiology. Heart and circulatory physiology.

Molecular physiology of renal ClC chloride channels/transporters

A. George, S. Sile, C. Vanoye, 2006, Current opinion in nephrology and hypertension.

Ranolazine selectively blocks persistent current evoked by epilepsy‐associated NaV1.1 mutations

A. George, S. Rajamani, Kristopher M. Kahlig, 2010, British journal of pharmacology.

Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy

Carlos G. Vanoye, Alfred L. George, A. George, 2017, Neurology: Genetics.

Autonomic control of heart rate and QT interval variability influences arrhythmic risk in long QT syndrome type 1.

A. Porta, P. Schwartz, P. Brink, 2015, Journal of the American College of Cardiology.

Single-channel Properties of Human NaV1.1 and Mechanism of Channel Dysfunction in SCN1A-associated Epilepsy

A. George, Christoph Lossin, C. Vanoye, 2006, The Journal of general physiology.

Common KCNH2 Polymorphism (K897T) as a genetic modifier of congenital long QT syndrome

D. Roden, P. Schwartz, Ping Yang, 2005 .

A common polymorphism in KCNH2 (HERG) eliminates gender differences in drug-induced QT prolongation

Niloufar B. Gillani, D. Roden, P. Kannankeril, 2005 .

Polymorphisms in Beta‐Adrenergic Receptor Genes in the Acquired Long QT Syndrome

D. Roden, R. Kim, Hong-Guang Xie, 2002, Journal of cardiovascular electrophysiology.

Aging‐associated down‐regulation of ClC‐1 expression in skeletal muscle: phenotypic‐independent relation to the decrease of chloride conductance

A. George, A. De Luca, S. Pierno, 1999, FEBS letters.

Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.

Jens Meiler, Carlos G Vanoye, Charles R Sanders, 2008, Biochemistry.

Molecular genetics of ion channel diseases.

A. George, A. George, 1995, Kidney international.

Differential effects of homologous S4 mutations in human skeletal muscle sodium channels on deactivation gating from open and inactivated states

P. Ruben, A. George, E. Fujimoto, 1999, The Journal of physiology.

Multiplexed transposon-mediated stable gene transfer in human cells

A. George, Matthew H. Wilson, Kristopher M. Kahlig, 2010, Proceedings of the National Academy of Sciences.

Functional consequences of a KCNT1 variant associated with status dystonicus and early‐onset infantile encephalopathy

Christopher H. Thompson, C. H. Thompson, Tracy S. Gertler, 2019, Annals of clinical and translational neurology.

Nonfunctional SCN1A Is Common in Severe Myoclonic Epilepsy of Infancy

A. George, Dao-wu Wang, I. Ohmori, 2006, Epilepsia.

Chloride channels and endocytosis: ClC-5 makes a dent.

A. George, A. George, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Designing and testing chimeric zinc finger transposases.

Matthew H. Wilson, A. George, 2010, Methods in molecular biology.

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

Christopher H. Thompson, E. Kiskinis, K. Swoboda, 2018, Neurobiology of Disease.

Low-Pass Filtering Approach via Empirical Mode Decomposition Improves Short-Scale Entropy-Based Complexity Estimation of QT Interval Variability in Long QT Syndrome Type 1 Patients

Sergio Cerutti, A. Porta, Vlasta Bari, 2014, Entropy.

High Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance

Alfred L. George, Carlos G. Vanoye, Reshma R. Desai, 2017, bioRxiv.

Disease-linked supertrafficking of a potassium channel

C. Sanders, J. Meiler, A. George, 2021, The Journal of biological chemistry.

Antiepileptic activity of preferential inhibitors of persistent sodium current

Christopher H. Thompson, W. Frankel, S. Rajamani, 2014, Epilepsia.

Disease-Linked Super-Trafficking of a Mutant Potassium Channel

C. Sanders, J. Meiler, A. George, 2020, bioRxiv.

Leaky channels make weak muscles.

A. George, 2012, The Journal of clinical investigation.

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

C. Sanders, J. Meiler, A. George, 2020, eLife.

Location and orientation of minK within the I(Ks) potassium channel complex.

A. George, A. Tapper, A. George, 2001, The Journal of biological chemistry.

Ranolazine Reduces Neuronal Excitability by Interacting with Inactivated States of Brain Sodium Channels

A. George, S. Rajamani, L. Belardinelli, 2014, Molecular Pharmacology.

Azithromycin Causes a Novel Proarrhythmic Syndrome

Wei Zhang, K. Murray, D. Roden, 2017, Circulation. Arrhythmia and electrophysiology.