D. Edmonds

发表

Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs.

A. Kalgutkar, M. Varma, J. Litchfield, 2020, Journal of medicinal chemistry.

Cascade reactions in total synthesis.

K C Nicolaou, K. Nicolaou, David J Edmonds, 2006, Angewandte Chemie.

Kaskadenreaktionen in der Totalsynthese

K. Nicolaou, P. Bulger, D. J. Edmonds, 2006 .

Total syntheses of (+/-)-platencin and (-)-platencin.

K. Nicolaou, D. J. Edmonds, G. Tria, 2009, Journal of the American Chemical Society.

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor

Margaret S. Landis, A. Mathiowetz, P. Loria, 2020, bioRxiv.

Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.

A. Mathiowetz, P. Loria, David A. Price, 2015, Journal of medicinal chemistry.

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy

R. Kurumbail, M. Birnbaum, A. Kalgutkar, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families

Ang Li, Peng Yang, D. J. Edmonds, 2015, Nature Communications.

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase (ACC) Inhibitors Through Liver Targeting.

David A. Price, A. Kalgutkar, S. Liras, 2020, Journal of medicinal chemistry.

Recent advances in the chemistry and biology of naturally occurring antibiotics.

K. Nicolaou, Jason S. Chen, Anthony A. Estrada, 2009, Angewandte Chemie.

Samarium(II)-iodide-mediated cyclizations in natural product synthesis.

D. Procter, D. J. Edmonds, D. Johnston, 2004, Chemical reviews.

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

P. Loria, David A. Price, S. Liras, 2017, European journal of medicinal chemistry.

Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro*

D. Craik, P. Loria, David A. Price, 2016, The Journal of Biological Chemistry.

Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.

A. Mathiowetz, D. Beebe, R. L. Dow, 2013, Journal of medicinal chemistry.

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).

R. Kurumbail, A. Kalgutkar, B. Feng, 2018, Journal of medicinal chemistry.

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.

D. Craik, P. Loria, David A. Price, 2015, European journal of medicinal chemistry.

Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).

G. S. Walker, R. Kurumbail, Jake E. Delmore, 2018, Journal of medicinal chemistry.

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.

Jessica Ward, Jun Xiao, David Hepworth, 2016, Journal of medicinal chemistry.

6-Azaspiro[2.5]octanes as Small Molecule Agonists of the Human Glucagon-Like Peptide-1 Receptor.

A. Mathiowetz, C. Limberakis, Edward L. Conn, 2023, Bioorganic & Medicinal Chemistry Letters.

Endothelin Antagonists for the Treatment of Pulmonary Arterial Hypertension

D. J. Edmonds, D. Edmonds, 2010 .

Asymmetric total syntheses of platensimycin.

K. Nicolaou, Ang Li, D. J. Edmonds, 2007, Angewandte Chemie.