A. Mcardle

R. Mestril, A. McArdle, Wolfgang H. Dillmann, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes

R. Griffiths, F. McArdle, M. Jackson, 2015, Redox biology.

Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing

A. McArdle, R. Barrett-Jolley, A. Vasilaki, 2022, Skeletal muscle.

Skeletal Muscle Damage with Exercise and Aging

A. McArdle, G. Close, A. Vasilaki, 2005, Sports medicine.

Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle.

W. Fraser, M. Jackson, W. Gregson, 2014, Free radical biology & medicine.

Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age

F. McArdle, A. McArdle, A. Vasilaki, 2006, Mechanisms of Ageing and Development.

Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity

J. Faulkner, H. Remmen, M. Jackson, 2006, Aging cell.

Exogenous glutamine: The clinical evidence

R. Griffiths, A. McArdle, T. Bongers, 2007, Critical care medicine.

Exercise and skeletal muscle ageing: cellular and molecular mechanisms

M. Jackson, A. McArdle, A. Vasilaki, 2002, Ageing Research Reviews.

Preconditioning of skeletal muscle against contraction‐induced damage: the role of adaptations to oxidants in mice

F. McArdle, M. Jackson, A. McArdle, 2004, The Journal of physiology.

Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation

C. Kahn, H. Remmen, M. Jackson, 2010, AGE.

Hyperthermia to normal human skin in vivo upregulates heat shock proteins 27, 60, 72i and 90

L. Rhodes, M. Jackson, C. Foster, 2000, Journal of cutaneous pathology.

Reduced carbohydrate availability does not modulate training-induced heat shock protein adaptations but does upregulate oxidative enzyme activity in human skeletal muscle.

T. Reilly, B. Drust, J. Bartlett, 2009, Journal of applied physiology.

Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

A. Gusnanto, A. McArdle, M. Fenech, 2020, medRxiv.

A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse

S. Espinoza, M. Jackson, A. Richardson, 2017, GeroScience.

Measurement of free radical production by in vivo microdialysis during ischemia/reperfusion injury to skeletal muscle.

R. Griffiths, A. McArdle, D. Pattwell, 2001, Free radical biology & medicine.

Aberrant redox signalling and stress response in age-related muscle decline: Role in inter- and intra-cellular signalling.

M. Jackson, A. McArdle, N. Pollock, 2019, Free radical biology & medicine.

Oxidative stress in skeletal muscle: Unraveling the potential beneficial and deleterious roles of reactive oxygen species

M. Jackson, C. Stretton, A. McArdle, 2020 .

M. Jackson, A. McArdle, A. Mcardle, 2011, The Journal of physiology.

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy

R. Griffiths, M. Jackson, A. McArdle, 2016, Scientific Reports.

Long-term administration of the mitochondria-targeted antioxidant mitoquinone mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle

R. Griffiths, M. Jackson, A. McArdle, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Effect of Vitamin C Supplements on Antioxidant Defence and Stress Proteins in Human Lymphocytes and Skeletal Muscle

R. Griffiths, D. Brodie, F. McArdle, 2003, The Journal of physiology.

Time course of responses of human skeletal muscle to oxidative stress induced by nondamaging exercise.

D. Brodie, M. Jackson, A. McArdle, 2001, Journal of applied physiology.

The Exercise-Induced Stress Response of Skeletal Muscle, with Specific Emphasis on Humans

B. Drust, A. McArdle, J. Morton, 2009, Sports medicine.

Redox Control of Signalling Responses to Contractile Activity and Ageing in Skeletal Muscle

M. Jackson, A. McArdle, N. Pollock, 2022, Cells.

Understanding the origin of non-immune cell-mediated weakness in the idiopathic inflammatory myopathies – potential role of ER stress pathways

R. Cooper, K. Nagaraju, A. McArdle, 2015, Current opinion in rheumatology.

Vitamin E and the Oxidative Stress of Exercise

F. McArdle, A. McArdle, A. Vasilaki, 2004, Annals of the New York Academy of Sciences.

Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice

M. Jackson, A. Richardson, A. McArdle, 2020, Aging cell.

A. McArdle, K. Goljanek-Whysall, Ana Soriano-Arroquia, 2016, Aging cell.

Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65–72 years

A. McArdle, H. Kröger, M. Tuppurainen, 2021, European Journal of Nutrition.

Time course and differential responses of the major heat shock protein families in human skeletal muscle following acute nondamaging treadmill exercise.

R. Griffiths, B. Drust, I. Campbell, 2006, Journal of applied physiology.

The role of hormones, cytokines and heat shock proteins during age-related muscle loss.

R. Griffiths, A. McArdle, Claire E. Lee, 2007, Clinical nutrition.

Skeletal Muscle Contractions Induce Acute Changes in Cytosolic Superoxide, but Slower Responses in Mitochondrial Superoxide and Cellular Hydrogen Peroxide

M. Jackson, J. Chamberlain, A. McArdle, 2014, PloS one.

2-Cys peroxiredoxin oxidation in response to hydrogen peroxide and contractile activity in skeletal muscle: A novel insight into exercise-induced redox signalling?

M. Jackson, C. Stretton, A. McArdle, 2020, Free radical biology & medicine.

Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.

M. Jackson, A. Richardson, A. McArdle, 2018, Antioxidants & redox signaling.

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Yun Shi, M. Jackson, Yiqiang Zhang, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase(s) in the increased skeletal muscle superoxide generation that occurs during contractile activity.

M. Jackson, A. McArdle, J. Palomero, 2013, Antioxidants & redox signaling.

Microdialysis studies of extracellular reactive oxygen species in skeletal muscle: factors influencing the reduction of cytochrome c and hydroxylation of salicylate.

M. Jackson, A. McArdle, G. Close, 2005, Free radical biology & medicine.

Role of mitochondrial superoxide dismutase in contraction-induced generation of reactive oxygen species in skeletal muscle extracellular space.

C. Epstein, J. Faulkner, M. Jackson, 2004, American journal of physiology. Cell physiology.

In vivo microdialysis—A technique for analysis of chemical activators of muscle pain

R. Edwards, M. Jackson, A. McArdle, 1999, Muscle & nerve.

How does dystrophin deficiency lead to muscle degeneration? — Evidence from the MDX mouse

M. Jackson, A. McArdle, Rachel Edwards, 1995, Neuromuscular Disorders.

Time course of changes in plasma membrane permeability in the dystrophin‐deficient mdx mouse

R. Edwards, M. Jackson, A. McArdle, 1994, Muscle & nerve.

Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes

F. McArdle, M. Jackson, A. Crozier, 2016, British Journal of Nutrition.

Effects of whey and soy protein supplementation on inflammatory cytokines in older adults: a systematic review and meta-analysis

M. Mazidi, A. McArdle, R. Sankaranarayanan, 2022, British Journal of Nutrition.

Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

C. Mazzà, M. Narici, J. V. van Dieën, 2018, Age and ageing.

Formation of 3‐nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle

J. Faulkner, R. Beynon, D. Simpson, 2007, Proteomics. Clinical applications.

The exercise-induced stress response in skeletal muscle: failure during aging.

A. McArdle, J. Morton, A. Kayani, 2008, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Heat shock factor activation in human muscles following a demanding intermittent exercise protocol is attenuated with hyperthermia

L. Nybo, B. Nielsen, M. Mohr, 2008, Acta physiologica.

dysfunction in hyperthyroid rat diaphragm Myofibrillar protein oxidation and contractile

R. Cooper, M. Jackson, T. Murase, 2015 .

Damage to developing mouse skeletal muscle myotubes in culture: protective effect of heat shock proteins

A. McArdle, A. Vasilaki, M. Jackson, 2003, The Journal of physiology.

Release of reactive oxygen and nitrogen species from contracting skeletal muscle cells. Free Radic. Biol. Med. 37:1064–1072; 2004

M. Jackson, J. Morgan, A. McArdle, 2004 .

Release of reactive oxygen and nitrogen species from contracting skeletal muscle cells.

M. Jackson, J. Morgan, A. McArdle, 2004, Free radical biology & medicine.

Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage

M. Jackson, A. McArdle, B. McDonagh, 2016, Free radical biology & medicine.

Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity

Anne McArdle, Malcolm J Jackson, Aphrodite Vasilaki, 2002, Muscle & nerve.

Skeletal muscle aging

A. McArdle, A. Vasilaki, C. Broome, 2007 .

Exercise stress leads to an acute loss of mitochondrial proteins and disruption of redox control in skeletal muscle of older subjects: An underlying decrease in resilience with aging?

Philip J. Brownridge, M. Jackson, C. Stretton, 2021, Free radical biology & medicine.

Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice.

J. Faulkner, M. Jackson, A. Richardson, 2019, Free radical biology & medicine.

Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing

M. Jackson, A. Richardson, A. McArdle, 2017, The Journal of physiology.

The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function.

M. Jackson, A. McArdle, A. Mcardle, 2017, Essays in biochemistry.

Role of reactive oxygen species in age‐related neuromuscular deficits

M. Jackson, A. McArdle, A. Mcardle, 2016, The Journal of physiology.

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype

K. Sataranatarajan, M. Jackson, Yiqiang Zhang, 2015, Redox biology.

Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice

Yun Shi, M. Jackson, Yiqiang Zhang, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of superoxide–nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase

F. McArdle, M. Jackson, A. Richardson, 2011, Aging cell.

M. Jackson, A. Richardson, A. McArdle, 2010, Aging cell.

Deletion of Sod1 in Motor Neurons Exacerbates Age-Related Changes in Axons and Neuromuscular Junctions in Mice

A. McArdle, H. Van Remmen, Alex Richardson, 2023, eNeuro.

Deletion of Sod1 in motor neurons exacerbates age-related changes in axons and NMJs associated with premature muscle atrophy in aging mice

A. McArdle, H. Van Remmen, A. Vasilaki, 2022, bioRxiv.

Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide

M. Jackson, A. McArdle, T. Pearson, 2015, Free radical biology & medicine.

Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal muscle fibers at rest, but not during contractions

M. Jackson, A. McArdle, J. Palomero, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Effect of lifelong overexpression of HSP70 in skeletal muscle on age‐related oxidative stress and adaptation after nondamaging contractile activity

M. Jackson, R. Mestril, A. McArdle, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

HyPer2 imaging reveals temporal and heterogeneous hydrogen peroxide changes in denervated and aged skeletal muscle fibers in vivo

M. Jackson, A. McArdle, R. Barrett-Jolley, 2019, Scientific Reports.

Accelerated age-related loss of muscle mass in homozygotic SOD1 knockout mice is not associated with neuronal oxidative damage

H. Remmen, M. Jackson, S. Brooks, 2013, Free Radical Biology and Medicine.

Intracellular generation of reactive oxygen species by contracting skeletal muscle cells.

F. McArdle, M. Jackson, A. McArdle, 2005, Free radical biology & medicine.

Hydrogen peroxide as a signal for skeletal muscle adaptations to exercise: What do concentrations tell us about potential mechanisms?

M. Jackson, C. Stretton, A. McArdle, 2020, Redox biology.

Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation

J. Viña, M. Gómez-Cabrera, A. McArdle, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Enhanced recovery from contraction-induced damage in skeletal muscles of old mice following treatment with the heat shock protein inducer 17-(allylamino)-17-demethoxygeldanamycin.

M. Jackson, A. McArdle, G. Close, 2008, Rejuvenation research.

Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits.

M. Jackson, A. McArdle, G. Close, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells.

M. Csete, J. Faulkner, F. McArdle, 2006, Free Radical Biology & Medicine.

Cellular mechanisms underlying oxidative stress in human exercise.

M. Jackson, A. McArdle, A. Vasilaki, 2016, Free radical biology & medicine.

Markers of oxidative stress in the skeletal muscle of patients on haemodialysis.

G. Kemp, R. Griffiths, F. McArdle, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Release of superoxide from skeletal muscle of adult and old mice: an experimental test of the reductive hotspot hypothesis

M. Jackson, A. McArdle, G. Close, 2007, Aging cell.

Keeping Up Defenses

R. Griffiths, A. McArdle, A. Mcardle, 2004, Science's STKE.

Contraction-induced injury to the extensor digitorum longus muscles of rats: the role of vitamin E.

J. Faulkner, M. Jackson, A. McArdle, 1997, Journal of applied physiology.

Reactive Oxygen Species Generation and Skeletal Muscle Wasting – Implications for Sarcopenia

M. Jackson, A. McArdle, A. Mcardle, 2011 .

Free radical activity following contraction-induced injury to the extensor digitorum longus muscles of rats.

J. Faulkner, M. Jackson, M. Catapano, 1999, Free radical biology & medicine.

Older mice show decreased regeneration of neuromuscular junctions following lengthening contraction-induced injury

M. Jackson, A. McArdle, S. Brooks, 2023, GeroScience.

Redox responses in skeletal muscle following denervation

M. Jackson, A. McArdle, S. Brooks, 2019, Redox biology.

The effect of lengthening contractions on neuromuscular junction structure in adult and old mice

M. Jackson, T. Pearson, A. Vasilaki, 2016, AGE.

An Introduction to a Special Issue of Free Radical Biology and Medicine - "Reactive Oxygen Species and Musculoskeletal Aging".

M. Jackson, A. McArdle, A. Mcardle, 2019, Free radical biology & medicine.

Removal of p16 INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice

J. Markworth, A. McArdle, H. Van Remmen, 2022, Frontiers in Aging.

Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle Cross-Sectional Area.

M. Jackson, R. Mestril, A. McArdle, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Workshop report: Can an understanding of the mechanisms underlying age-related loss of muscle mass and function guide exercise and other intervention strategies?

Anne McArdle, Malcolm J Jackson, Aphrodite Vasilaki, 2012, Longevity & healthspan.

fibers during development increased force generation by rat diaphragm muscle Selected Contribution: Mechanisms underlying

H. Remmen, C. Mantilla, G. Sieck, 2015 .

Effects of calcium on protein turnover of incubated muscles from mdx mice.

R. Edwards, P. MacLennan, A. McArdle, 1991, The American journal of physiology.

Understanding the origin of non-immune cell-mediated weakness in the idiopathic inflammatory myopathies – potential role of ER stress pathways

R. Cooper, K. Nagaraju, Adam P Lightfoot, 2015, Current opinion in rheumatology.

Muscle in defense

R. Griffiths, Adam P Lightfoot, A. Mcardle, 2009, Critical care medicine.

Elevated core and muscle temperature to levels comparable to exercise do not increase heat shock protein content of skeletal muscle of physically active men

R. Griffiths, B. Drust, I. Campbell, 2007, Acta physiologica.

Interactions of Short-Term and Chronic Treadmill Training With Aging of the Left Ventricle of the Heart

K. Rostron, A. McArdle, R. Walton, 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

‘Molecular habituation’ as a potential mechanism of gradual homeostatic loss with age

Ciaran M. Welsh, D. Shanley, C. Proctor, 2017, Mechanisms of Ageing and Development.

Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor κB activation

M. Jackson, L. Larkin, S. Brooks, 2008, The Journal of physiology.

Time course of responses of human skeletal muscle to exercise-induced oxidative stress

R. Griffiths, M. Jackson, A. Mcardle, 2001 .

Exercise training–induced gender‐specific heat shock protein adaptations in human skeletal muscle

A. McArdle, J. Morton, Kathryn Holloway, 2009, Muscle & nerve.

Trained men display increased basal heat shock protein content of skeletal muscle.

B. Drust, I. Campbell, A. McArdle, 2008, Medicine and science in sports and exercise.

Gathering insights on disease etiology from gene expression profiles of healthy tissues

J. de Magalhães, S. Wood, Sipko van Dam, 2011, Bioinform..

R. Griffiths, M. Jackson, T. Pearson, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Ischaemic preconditioning of skeletal muscle 2. Investigation of the potential mechanisms involved.

L. Klenerman, I. Grierson, M. Jackson, 2002, The Journal of bone and joint surgery. British volume.

Reliability of maximal muscle force and voluntary activation as markers of exercise-induced muscle damage

Greg Atkinson, Barry Drust, Anne McArdle, 2005, European Journal of Applied Physiology.

M. Jackson, J. Palomero, A. Vasilaki, 2013, Antioxidants & redox signaling.

Studies of mitochondrial and non‐mitochondrial sources implicate NADPH oxidase(s) in the increased skeletal muscle superoxide generation that occurs during contractile activity

M. Jackson, J. Palomero, A. Vasilaki, 2012 .

Free Radicals, Muscle Fatigue and Damage

M. Jackson, A. McArdle, S. O'Farrell, 1995 .

oxidative stress induced by nondamaging exercise Time course of responses of human skeletal muscle to

G. Lamb, D. Brodie, A. Lucia, 2013 .

Cristian Esanu and oxidative stress induced by nondamaging exercise Time course of responses of human skeletal muscle to

D. Brodie, M. Jackson, A. McArdle, 2000 .

Accumulation of calcium by normal and dystrophin-deficient mouse muscle during contractile activity in vitro.

R. Edwards, M. Jackson, A. McArdle, 1992, Clinical science.

Antioxidant micronutrients and gene expression

F. McArdle, M. Jackson, A. McArdle, 1998, Proceedings of the Nutrition Society.