S. Léonce

发表

Antiproliferative and anticarcinogenic effects of an aqueous preparation of Abies alba and Viscum album se abies, on a L-1210 malignant cell line and tumor-bearing Wistar rats.

A. Evangelou, A. Skaltsounis, S. Léonce, 2000, Anticancer research.

S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab

G. Ferry, J. Boutin, J. Hickman, 2013, Molecular Cancer Therapeutics.

Synthesis, cytotoxic activity, and mechanism of action of furo[2,3-c]acridin-6-one and benzo[b]furo[3,2-h]acridin-6-one analogues of psorospermin and acronycine.

B. Pfeiffer, Marie-Christine Lallemand, F. Tillequin, 2008, Journal of medicinal chemistry.

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.

B. Pfeiffer, M. Prudhomme, R. Golsteyn, 2006, Bioorganic & medicinal chemistry.

An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells.

B. Pfeiffer, J. Hickman, R. Golsteyn, 2010, Cancer letters.

Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment

J. Hickman, L. Meijer, A. Borgne, 2006, Oncogene.

MYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model.

J. Bénard, M. Barrois, S. Léonce, 2003, The American journal of pathology.

Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs

C. Bailly, J. Hickman, G. Lavielle, 2007, Molecular Pharmacology.

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework.

B. Pfeiffer, M. Prudhomme, S. Messaoudi, 2005, European journal of medicinal chemistry.

Cells Derived from Regenerated Endothelium of the Porcine Coronary Artery Contain More Oxidized Forms of Apolipoprotein-B-100 without a Modification in the Uptake of Oxidized LDL

P. Vanhoutte, J. Vilaine, S. Léonce, 2003, Journal of Vascular Research.

Synthesis and biological activities of isogranulatimide analogues.

C. Bailly, B. Pfeiffer, J. Hickman, 2007, Bioorganic & medicinal chemistry.

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione.

B. Pfeiffer, M. Prudhomme, R. Golsteyn, 2006, European journal of medicinal chemistry.

Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.

P. Peixoto, B. Pfeiffer, M. Prudhomme, 2006, Bioorganic & medicinal chemistry.

Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties.

P. Renard, B. Pfeiffer, M. Prudhomme, 2003, Bioorganic & medicinal chemistry.

Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.

C. Bailly, P. Renard, B. Pfeiffer, 2003, Journal of medicinal chemistry.

Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens.

P. Renard, B. Pfeiffer, M. Prudhomme, 2002, Journal of medicinal chemistry.

Synthesis and biological activities of indolocarbazoles bearing amino acid residues.

C. Bailly, M. Sancelme, B. Pfeiffer, 2001, European journal of medicinal chemistry.

Rebeccamycin analogues from indolo[2,3-c]carbazole.

C. Bailly, P. Colson, M. Sancelme, 2001, Bioorganic & medicinal chemistry.

In vitro cytotoxicity of S16020-2, a new olivacine derivative

E. Bisagni, A. Pierré, S. Léonce, 2004, Investigational New Drugs.

Cellular knock-down of quinone reductase 2: a laborious road to successful inhibition by RNA interference.

G. Ferry, J. Boutin, P. Delagrange, 2007, Biochimie.

Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.

C. Bailly, P. Colson, L. Kraus-Berthier, 2004, Biochemical pharmacology.

Comparison of the pharmacological profile of an olivacine derivative and a potential prodrug

S. Goldstein, L. Kraus-Berthier, A. Pierré, 2002, Cancer Chemotherapy and Pharmacology.

Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.

P. Peixoto, C. Bailly, D. Caignard, 2005, Journal of medicinal chemistry.

Synthesis and in vitro cytotoxic evaluation of N-substituted benzo[5,6]cycloheptal[b]indoles.

D. Alagille, B. Joseph, S. Léonce, 2000, Chemical & pharmaceutical bulletin.

Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis.

B. Pfeiffer, J. Hickman, M. Koch, 2001, Molecular pharmacology.

Phenotypic and functional changes in regenerated porcine coronary endothelial cells : increased uptake of modified LDL and reduced production of NO.

P. Vanhoutte, J. Vilaine, S. Léonce, 2000, Circulation research.

Synthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group.

Y. Li, P. Renard, Jian Ding, 2003, Bioorganic & medicinal chemistry.

Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and pyrano[2,3-c]thioxanthen-7-ones.

P. Renard, A. Skaltsounis, E. Mikros, 2001, Bioorganic & medicinal chemistry.

Synthesis and cytotoxic activity of 2-dialkylaminoethylamino substituted xanthenone and thioxanthenone derivatives.

A. Skaltsounis, D. Caignard, P. Marakos, 2000, Farmaco.

Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.

C. Bailly, J. Hickman, J. Kluza, 2002, Biochemical pharmacology.

Novel benzopyridothiadiazepines as potential active antitumor agents.

P. Renard, B. Pfeiffer, P. Chavatte, 2005, Journal of medicinal chemistry.

Synthesis and Conformational Analysis of Some New Pyrano[2,3-c]xanthen-7-one and Pyrano[3,2-b]xanthen-6-one Derivatives with Cytotoxic Activity

A. Skaltsounis, D. Caignard, P. Marakos, 2000 .

Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1.

C. Bailly, C. Tardy, M. Kouach, 2003, European journal of biochemistry.

SYNTHESIS AND ANTIANGIOGENIC ACTIVITY OF NEW CARBOHYDRATE DERIVATIVES

D. Billington, S. Léonce, G. Atassi, 1996 .

Synthesis and cytotoxic activity of psorospermin and acronycine analogues in the 3-propyloxy-acridin-9(10H)-one and -benzo[b]acridin-125H-one series.

B. Pfeiffer, Marie-Christine Lallemand, F. Tillequin, 2010, European journal of medicinal chemistry.

Characterization of novel checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors.

G. Ferry, J. Boutin, B. Pfeiffer, 2011, Life sciences.

Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage.

S. Léonce, G. de Nanteuil, M. Sabatini, 2000, Biochemical and biophysical research communications.

Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle.

P. Renard, D. Caignard, P Renard, 2001, Bioorganic & medicinal chemistry letters.

In vitro andin vivo circumvention of multidrug resistance by Servier 9788, a novel triazinoaminopiperidine derivative

L. Kraus-Berthier, A. Pierré, S. Léonce, 1992, Investigational New Drugs.

Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.

S. Léonce, G. Atassi, V. Pérez, 1992, Biochemical pharmacology.

Multicentric evaluation of the MDR phenotype in leukemia

J. Rossi, F. Pinguet, B. Drénou, 1997, Leukemia.

Cytotoxic and antitumoral properties in a series of new, ring D modified, olivacine analogues.

S. Goldstein, L. Kraus-Berthier, A. Pierré, 2005, Bioorganic & medicinal chemistry.

New triazine derivatives as potent modulators of multidrug resistance.

J. Prost, L. Kraus-Berthier, S. Léonce, 1992, Journal of medicinal chemistry.

Synthesis and cytotoxic and antitumor activity of esters in the 1,2-dihydroxy-1,2-dihydroacronycine series.

A. Skaltsounis, F. Tillequin, L. Kraus-Berthier, 1996, Journal of medicinal chemistry.

Benzopyridooxathiazepine derivatives as novel potent antimitotic agents.

P. Renard, B. Pfeiffer, S. Gallet, 2009, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors.

B. Pfeiffer, S. E. Kazzouli, S. El Kazzouli, 2006, Bioorganic & medicinal chemistry.

Synthesis and in vitro antitumour evaluation of benzothiazole-2-carbonitrile derivatives

B. Pfeiffer, T. Besson, J. Guillard, 1999 .

Relationship between the cellular accumulation and the cytotoxicity of S12363, a new vinca alkaloid derivative

J. Boutin, G. Lavielle, A. Pierré, 2004, Cancer Chemotherapy and Pharmacology.

Cytotoxic activities of novel hexahydroindolizino[8,7-b]indole derivatives prepared by 1,3-dipolar cycloaddition reactions of 3,4-dihydro-beta-carboline ylides.

P. Renard, B. Pfeiffer, G. Werner, 2001, Bioorganic & medicinal chemistry.

Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin.

C. Bailly, J. Hickman, W. Laine, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.

P. Renard, B. Pfeiffer, C. Monneret, 2005, Journal of medicinal chemistry.

Synthesis and biological evaluation of aristolactams.

P. Renard, B. Pfeiffer, A. Couture, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds.

P. Renard, B. Pfeiffer, C. Monneret, 2006, European journal of medicinal chemistry.

First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin

Eric Deniau, Pierre Renard, Axel Couture, 2000 .

Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.

C. Bailly, P. Colson, B. Pfeiffer, 2004, Bioorganic & medicinal chemistry.

An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells.

B. Pfeiffer, J. Hickman, R. Golsteyn, 2010, Cancer letters.

Synthesis of Some 5′-Thiopentofuranosylpyrimidines as Potential Anti-tumor Agents.

L. Agrofoglio, S. Léonce, F. Girard, 1997 .

Synthesis and cytotoxic activity of pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents.

A. Fontana, J. Vaquero, D. Caignard, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of Pyrido[2,3-b]indole Derivatives via Diels–Alder Reactions of 2- and 3-Vinylpyrrolo[2,3-b]pyridines

B. Joseph, S. Léonce, J. Mérour, 2000 .

Characterization of novel checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors.

G. Ferry, J. Boutin, B. Pfeiffer, 2011, Life sciences.

Design, synthesis and antiproliferative activity of tripentones: a new series of antitubulin agents.

P. Renard, S. Rault, V. Lisowski, 2001, Bioorganic & medicinal chemistry letters.

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of dipyrrolo[3,4-a:3,4-c]carbazole-triones

B. Pfeiffer, M. Prudhomme, R. Golsteyn, 2006 .

Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.

D. Caignard, S. Routier, A. Pierré, 2010, Bioorganic & medicinal chemistry letters.