Joshua C. Munger

发表

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling*

S. Nadtochiy, P. Brookes, J. Munger, 2016, The Journal of Biological Chemistry.

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.

D. Green, H. Chi, D. Finkelstein, 2011, Immunity.

mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection

D. Walsh, J. Munger, N. Meade, 2019, Journal of Virology.

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

G. Reifenberger, T. Mak, A. Melnick, 2012, Nature.

The Human Cytomegalovirus UL38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2

J. Munger, X. Schafer, M. Monaghan, 2019, PLoS pathogens.

Metabolite profiles of human immunodeficiency virus infected CD4+ T cells and macrophages using LC-MS/MS analysis.

Baek Kim, J. Munger, J. Hollenbaugh, 2011, Virology.

Virology under the Microscope—a Call for Rational Discourse

Joshua R. Smith, A. Casadevall, M. Vignuzzi, 2023, mSphere.

Virology under the Microscope—a Call for Rational Discourse

Joshua R. Smith, A. Casadevall, M. Vignuzzi, 2023, mBio.

Virology under the Microscope—a Call for Rational Discourse

Joshua R. Smith, A. Casadevall, M. Vignuzzi, 2023, Journal of virology.

Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP–sugar synthesis to support viral protein glycosylation

J. Munger, L. Martínez-Sobrido, Emilio Ortiz-Riaño, 2014, Proceedings of the National Academy of Sciences.

Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation

I. Harris, J. Munger, X. Schafer, 2023, bioRxiv.

Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro

I. Harris, S. Dewhurst, J. Munger, 2020, bioRxiv.

The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins

B. Roizman, J. Munger, Bernard Roizman, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells

H. Land, Bradley Smith, J. Munger, 2016, Cell reports.

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

Xiao-Jiang Feng, Thomas Shenk, Joshua D Rabinowitz, 2008, Nature Biotechnology.

Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

L. Briant, P. Eldin, Kejia Zhang, 2023, bioRxiv.

Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling

J. Munger, X. Schafer, Isreal Moreno, 2022, bioRxiv.

A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Joerg M. Buescher, Christian M. Metallo, Jamey D. Young, 2015, Current opinion in biotechnology.

Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit To Drive Glycolytic Activation and Support Productive Viral Infection

D. Dunn, J. Munger, X. Schafer, 2020, Journal of Virology.

Inhibition of Calmodulin-Dependent Kinase Kinase Blocks Human Cytomegalovirus-Induced Glycolytic Activation and Severely Attenuates Production of Viral Progeny

J. Munger, X. Schafer, J. McArdle, 2010, Journal of Virology.

Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network

J. Munger, Shihao Xu, Christopher M. Goodwin, 2015, Trends in Microbiology.

UL26-Deficient Human Cytomegalovirus Produces Virions with Hypophosphorylated pp28 Tegument Protein That Is Unstable within Newly Infected Cells

T. Shenk, J. Munger, Dong Yu, 2006, Journal of Virology.

The Human Cytomegalovirus UL26 Protein Antagonizes NF-κB Activation

J. Munger, L. Martínez-Sobrido, X. Schafer, 2014, Journal of Virology.

Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.

S. Ghaemmaghami, S. Nadtochiy, P. Brookes, 2017, The Biochemical journal.

Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation.

S. Nadtochiy, P. Brookes, J. Munger, 2015, Journal of molecular and cellular cardiology.

Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling

J. Munger, J. Ciesla, C. M. Goodwin, 2018, Viruses.

Dynamics of the Cellular Metabolome during Human Cytomegalovirus Infection

Thomas Shenk, Joshua D Rabinowitz, Hilary A Coller, 2006, PLoS pathogens.

Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells*

John M. Ashton, Patricia Greninger, J. Settleman, 2013, The Journal of Biological Chemistry.

TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state

J. Munger, Isreal Moreno, J. Ciesla, 2022, bioRxiv.

CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages

Michael R. Elliott, W. Janssen, J. Munger, 2017, Cell Death and Differentiation.

CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages

Michael R. Elliott, W. Janssen, J. Munger, 2017, Cell Death & Differentiation.

Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation

S. Ghaemmaghami, S. Nadtochiy, P. Brookes, 2017, bioRxiv.

US3 Protein Kinase of Herpes Simplex Virus 1 Blocks Caspase 3 Activation Induced by the Products of US1.5 and UL13 Genes and Modulates Expression of Transduced US1.5 Open Reading Frame in a Cell Type-Specific Manner

B. Roizman, J. Munger, A. Poon, 2002, Journal of Virology.

FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis

Jiangbin Wu, K. C. Subbaiah, Peng Yao, 2023, bioRxiv.

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

P. Brookes, J. Munger, Yves T. Wang, 2018, Cell reports.

The IκB Kinases Restrict Human Cytomegalovirus Infection

J. Munger, C. M. Goodwin, Joshua C. Munger, 2019, Journal of Virology.

Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.

R. Schinazi, Baek Kim, J. Munger, 2016, Virology.

Inhibition of Arenavirus by A3, a Pyrimidine Biosynthesis Inhibitor

M. Shaw, J. C. de la Torre, D. Eggink, 2013, Journal of Virology.

Mutation of ataxia–telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia

M. Noble, J. Munger, Jared S. Bushman, 2016, Glia.

HCMV Targets the Metabolic Stress Response through Activation of AMPK Whose Activity Is Important for Viral Replication

Nathaniel J. Moorman, J. Munger, J. McArdle, 2012, PLoS pathogens.

Transformation with Oncogenic Ras and the Simian Virus 40 T Antigens Induces Caspase-Dependent Sensitivity to Fatty Acid Biosynthetic Inhibition

J. Munger, Shihao Xu, C. Spencer, 2015, Journal of Virology.

Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection

D. Dunn, J. Munger, Diana M. Dunn, 2020, Frontiers in Cellular and Infection Microbiology.

Glutathione supports lipid abundance in vivo

Ying Chen, V. Vasiliou, I. Harris, 2023, bioRxiv.

Bcl-2 Blocks a Caspase-Dependent Pathway of Apoptosis Activated by Herpes Simplex Virus 1 Infection in HEp-2 Cells

B. Roizman, R. Brandimarti, J. Munger, 2000, Journal of Virology.

The Herpes Simplex Virus 1 US3 Protein Kinase Blocks Caspase-Dependent Double Cleavage and Activation of the Proapoptotic Protein BAD

B. Roizman, J. Munger, L. Benetti, 2003, Journal of Virology.

Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis.

B. Roizman, J. Munger, R. Hagglund, 2003, Virology.

The US3 Protein Kinase Blocks Apoptosis Induced by the d120 Mutant of Herpes Simplex Virus 1 at a Premitochondrial Stage

B. Roizman, J. Munger, A. V. Chee, 2001, Journal of Virology.

Human Cytomegalovirus Induces the Activity and Expression of Acetyl-Coenzyme A Carboxylase, a Fatty Acid Biosynthetic Enzyme Whose Inhibition Attenuates Viral Replication

Nathaniel J. Moorman, J. Munger, X. Schafer, 2011, Journal of Virology.

Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells*

Patricia Greninger, J. Settleman, C. Benes, 2013, Journal of Biological Chemistry.

Myelogenous Leukemia Cells Metabolism to Eradicate Human Acute Targeting Aberrant Glutathione Molecular Bases of Disease :

Patricia Greninger, J. Settleman, Lei Shi, 2014 .

Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism

J. Munger, Irene Rodríguez-Sánchez, Joshua C. Munger, 2019, Viruses.

Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons

M. Noble, J. Munger, C. Proschel, 2014, EMBO molecular medicine.

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.

S. Nadtochiy, P. Brookes, J. Munger, 2018, Journal of molecular and cellular cardiology.

UL26 Attenuates IKKβ-Mediated Induction of Interferon-Stimulated Gene (ISG) Expression and Enhanced Protein ISGylation during Human Cytomegalovirus Infection

C. M. Goodwin, Xenia L. Schafer, Joshua C. Munger, 2019, Journal of Virology.

The Human Cytomegalovirus UL26 Protein Antagonizes NF-κB Activation

L. Martínez-Sobrido, Chun Mathers, Xenia L. Schafer, 2014, Journal of Virology.

Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection

J. Munger, X. Schafer, Shihao Xu, 2016, Journal of Virology.

VIRAL MANIPULATION OF CELLULAR METABOLIC SIGNAL TRANSDUCTION PATHWAYS

J. Munger, Joshua C. Munger, 2012 .

Raf1 promotes successful Human Cytomegalovirus replication and is regulated by AMPK-mediated phosphorylation during infection

J. Munger, Diana M. Dunn, Ludia J. Pack, 2023, bioRxiv.

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling*

S. Nadtochiy, P. Brookes, K. Nehrke, 2016, The Journal of Biological Chemistry.

FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.

Jiangbin Wu, K. C. Subbaiah, Peng Yao, 2023, Cardiovascular research.

Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

L. Briant, J. Munger, P. Eldin, 2024, eLife.

Contributions of the Human Cytomegalovirus UL30-Associated Open Reading Frames to Infection

J. Munger, M. Monaghan, Joshua C. Munger, 2021, Journal of Virology.

Inhibition of Arenavirus by A3, a Pyrimidine Biosynthesis Inhibitor

M. Shaw, J. C. de la Torre, L. Martínez-Sobrido, 2013, Journal of Virology.