Anders Poulsen

发表

Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.

A. Poulsen, Boping Liu, Jeffrey Hill, 2021, Bioorganic & medicinal chemistry.

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies

A. Poulsen, A. William, B. Dymock, 2011, Leukemia.

Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors.

Chang Kai Soh, A. Poulsen, Meredith Williams, 2012, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.

J. Yen, A. Poulsen, B. Dymock, 2016, Journal of medicinal chemistry.

SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents

A. Poulsen, Haishan Wang, Xukun Wang, 2006, Journal of biomolecular screening.

Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lympho

Anders Poulsen, Stéphanie Blanchard, Harish Nagaraj, 2011, Journal of medicinal chemistry.

Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.

J. Yen, A. Poulsen, B. Dymock, 2018, European journal of medicinal chemistry.

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.

J. Yen, A. Poulsen, B. Dymock, 2017, Journal of medicinal chemistry.

Structure-based design of Aurora A & B inhibitors

Eric Sun, Anders Poulsen, Anthony William, 2008, J. Comput. Aided Mol. Des..

Structure and Ligand-Based Design of mTOR and PI3-Kinase Inhibitors Leading to the Clinical Candidates VS-5584 (SB2343) and SB2602

Anders Poulsen, Stéphanie Blanchard, Angeline Lee, 2014, J. Chem. Inf. Model..

Discovery of a novel Mycobacterial F-ATP synthase inhibitor and its potency in combination with diarylquinolines.

W. Saw, G. Grüber, Joon Shin, 2020, Angewandte Chemie.

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques.

Rong Li, E. Guccione, Jianhe Peng, 2014, The Biochemical journal.

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Rong Li, Sugunavathi Sepramaniam, A. Poulsen, 2019, ACS medicinal chemistry letters.

Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

E. Rubin, A. Poulsen, T. Dick, 2015, mBio.

Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome

A. Poulsen, B. Dymock, T. Dick, 2017, Antimicrobial Agents and Chemotherapy.

Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.

Shi Hua Ang, C. Verma, S. Kannan, 2015, Biochemistry.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

Hong Kee Tan, D. Tenen, Y. S. Tan, 2018, Proceedings of the National Academy of Sciences.

Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.

J. Kwiatkowski, J. Cherian, Jeffrey Hill, 2019, ACS medicinal chemistry letters.

Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening.

Kay Lin Goh, Z. Bonday, J. Wood, 2012, Bioorganic & medicinal chemistry letters.

Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthr

J. Wood, A. Poulsen, A. William, 2012, Journal of medicinal chemistry.

nonaene ( SB 1578 ) , a Potent Inhibitor of Janus Kinase 2 / Fms-LikeTyrosine Kinase-3 ( JAK 2 / FLT 3 ) for the Treatment of Rheumatoid Arthritis

Anders Poulsen, Harish Nagaraj, Evelyn Tan, 2012 .

Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-

J. Wood, A. Poulsen, Meredith Williams, 2012, Journal of medicinal chemistry.

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity

D. Herr, A. Poulsen, B. Dymock, 2016, Peptides.

Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.

Kay Lin Goh, Z. Bonday, J. Wood, 2011, Journal of medicinal chemistry.

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.

Z. Bonday, Haishan Wang, Xukun Wang, 2009, Bioorganic & medicinal chemistry letters.

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Shi Hua Ang, Eldwin Sum Wai Tan, C. Chuah, 2018, Journal of medicinal chemistry.

Intranasal administration of a stapled relaxin‐3 mimetic has anxiolytic‐ and antidepressant‐like activity in rats

R. Kini, A. Poulsen, B. Dymock, 2019, British journal of pharmacology.

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

Xiao Han, A. Pobbati, W. Hong, 2015, Structure.

Discovery of Kinase Spectrum Selective Macrocycle

J. Wood, A. Poulsen, Meredith Williams, 2011 .

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

J. Kwiatkowski, A. Poulsen, Jeffrey Hill, 2020, Journal of medicinal chemistry.

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors.

Rong Li, A. Poulsen, S. Yao, 2021, Angewandte Chemie.

Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria.

Shi Hua Ang, G. Basarab, A. Poulsen, 2018, European journal of medicinal chemistry.

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption

A. Poulsen, T. Dick, Jeffrey Hill, 2018, Front. Microbiol..

Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4.

Rong Li, A. Pobbati, W. Hong, 2018, The Biochemical journal.

Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

A. Poulsen, J. Cherian, Boping Liu, 2016, Journal of medicinal chemistry.

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.

Shi Hua Ang, Eldwin Sum Wai Tan, A. Poulsen, 2017, Journal of medicinal chemistry.

Discovery and Optimization of a Porcupine Inhibitor.

Shi Hua Ang, Eldwin Sum Wai Tan, A. Poulsen, 2015, Journal of medicinal chemistry.

Pharmacophore and receptor models for neurokinin receptors

Klaus Gundertofte, Tommy Liljefors, Irina D. Pogozheva, 2003, J. Comput. Aided Mol. Des..

Fragment-based ligand design of novel potent inhibitors of tankyrases.

P. Nordlund, A. Poulsen, F. Ng, 2013, Journal of medicinal chemistry.

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

Xiao Han, A. Pobbati, W. Hong, 2015, Structure.

Supporting Information: Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl- ethoxy)-14,19-dioxa-5,7,26-triaza- tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa- 1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment o

Harish, J. Wood, Meredith Williams, 2011 .

Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease

A. Poulsen, F. Ng, Jeffrey Hill, 2016, Journal of enzyme inhibition and medicinal chemistry.

Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: a P3 and N-cap optimization study.

Jeffrey Hill, Wen-Yang Wu, J. Joy, 2013, European journal of medicinal chemistry.

Nutrient content in plant-based protein products intended for food composition databases

E. Trolle, A. Poulsen, J. Jakobsen, 2021, Journal of Food Composition and Analysis.

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

Shi Hua Ang, Eldwin Sum Wai Tan, J. Kwiatkowski, 2018, Journal of medicinal chemistry.

Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex.

S. Cohen, Wei Zhang, A. Poulsen, 2015, Cellular signalling.

Discovery and characterisation of the automethylation properties of PRDM9.

Rong Li, E. Guccione, Jianhe Peng, 2017, The Biochemical journal.

Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6).

A. Poulsen, B. Dymock, Lianbin Yao, 2018, Bioorganic & medicinal chemistry letters.