Debra M. Hunter

发表

UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

D. Newton, S. Frye, W. Janzen, 2014, Journal of medicinal chemistry.

UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo

S. Frye, W. Janzen, H. Earp, 2013, Molecular Cancer Therapeutics.

Data-driven construction of anti-tumor agents with controlled polypharmacology.

Laura E. Herring, S. Frye, M. Miley, 2019, Journal of the American Chemical Society.

TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti–PD-1 Therapy in Melanoma

S. Frye, Yuewei Zhang, Xiaodong Wang, 2019, Cancer Immunology Research.

Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group.

S. Frye, D. Drewry, Yuewei Zhang, 2018, Journal of medicinal chemistry.

Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

L. Caskey, H. Earp, Alisha Holtzhausen, 2018, The Journal of clinical investigation.

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.

Melissa A. Sandahl, Kristen M. Jacobsen, H. Earp, 2013, The Journal of clinical investigation.

UNC1062, a new and potent Mer inhibitor.

S. Frye, W. Janzen, H. Earp, 2013, European journal of medicinal chemistry.

Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.

S. Frye, W. Janzen, M. Machius, 2012, ACS medicinal chemistry letters.

Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation

Melissa A. Sandahl, H. Earp, M. Sandahl, 2010, BMC Developmental Biology.

The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.

Melissa A. Sandahl, H. Earp, K. Elenius, 2006, Molecular Biology of the Cell.

ErbB4 Splice Variants Cyt1 and Cyt2 Differ by 16 Amino Acids and Exert Opposing Effects on the Mammary Epithelium In Vivo

Melissa A. Sandahl, L. Chodosh, H. Earp, 2009, Molecular and Cellular Biology.

The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

Melissa A. Sandahl, L. Caskey, K. Miyazawa, 2008, Molecular and Cellular Biology.

Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation.

Melissa A. Sandahl, H. Earp, M. Sandahl, 2008, Molecular endocrinology.

The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation.

L. Caskey, H. Earp, C. Sartor, 2007, Molecular endocrinology.

HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4.

Melissa A. Sandahl, H. Earp, M. Sandahl, 2007, Cancer research.

HER 4 D-Box Sequences Regulate Mitotic Progression and Degradation of the Nuclear HER 4 Cleavage Product s 80 HER 4

Melissa A. Sandahl, H. Earp, M. Sandahl, 2007 .

Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.

S. Frye, W. Janzen, M. Machius, 2013, Journal of medicinal chemistry.

Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.

S. Frye, W. Janzen, M. Machius, 2013, Journal of medicinal chemistry.

Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

Amy Lynnette Van Deusen, S. Frye, W. Janzen, 2012 .

UNC 569 , a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo

S. Frye, W. Janzen, H. Earp, 2013 .

Regulation of a Calcium-dependent Tyrosine Kinase in Vascular Smooth Muscle Cells by Angiotensin II and Platelet-derived Growth Factor

L. Graves, B. Herman, H. Earp, 1998, The Journal of Biological Chemistry.

Heregulin-Dependent Delay in Mitotic Progression Requires HER4 and BRCA1

Melissa A. Sandahl, L. Caskey, K. Cowan, 2006, Molecular and Cellular Biology.

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.

Melissa A. Sandahl, Kristen M. Jacobsen, H. Earp, 2013, The Journal of clinical investigation.

SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)

Stephen J. Capuzzi, T. Willson, S. Knapp, 2018, bioRxiv.

Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.

S. Frye, M. Machius, M. Miley, 2013, Journal of medicinal chemistry.

The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.

Melissa A. Sandahl, H. Earp, K. Elenius, 2006, Molecular biology of the cell.