Steven Wink

发表

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

A. Kopp-Schneider, F. Bois, B. van de Water, 2018, Front. Genet..

Toxicogenomics directory of chemically exposed human hepatocytes

R. Stierum, G. Myatt, J. Rahnenführer, 2014, Archives of Toxicology.

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Bob van de Water, Harry Vrieling, Giel Hendriks, 2014, Chemical research in toxicology.

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

J. Foekens, M. Timmermans, M. Smid, 2019, Nature Communications.

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Giulia Callegaro, Bob van de Water, Maarten Coonen, 2019, Archives of Toxicology.

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

B. van de Water, S. Wink, S. Hiemstra, 2018, Archives of Toxicology.

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

G. Groothuis, E. Danen, B. van de Water, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes.

C. Verfaillie, B. van de Water, R. Boon, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

User-friendly high-content imaging analysis on a single desktop: R package H5CellProfiler

Sylvia E. Le Dévédec, B. van de Water, S. L. Le Dévédec, 2022, bioRxiv.

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

B. van de Water, G. Hendriks, H. Vrieling, 2015, Archives of Toxicology.

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Bob van de Water, Steven Wink, B. van de Water, 2016, Archives of Toxicology.

Integration of temporal single cell cellular stress response activity with Logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.

Sylvia E. Le Dévédec, J. Saez-Rodriguez, J. Hengstler, 2021, Biochemical pharmacology.

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

Sylvia E. Le Dévédec, J. Foekens, M. Timmermans, 2019, Nature Communications.

Mining a human transcriptome database for chemical modulators of NRF2

J. Corton, D. Bell, B. van de Water, 2020, PloS one.

FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells.

Sylvia E. Le Dévédec, Yinghui Zhang, B. van de Water, 2019, Biochemical pharmacology.

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

Bob van de Water, Steven Wink, B. van de Water, 2018, Archives of Toxicology.

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

Bas ter Braak, Bob van de Water, Jan Willem van der Laan, 2015, Breast Cancer Research.

Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

J. C. Gómez-Tamayo, G. V. van Westen, U. Norinder, 2023, J. Chem. Inf. Model..

Systems Microscopy Approaches in Unraveling and Predicting Drug-Induced Liver Injury (DILI)

B. Water, S. Wink, B. T. Braak, 2018 .

Toxicogenomics directory of chemically exposed human hepatocytes

R. Stierum, G. Myatt, J. Rahnenführer, 2014, Archives of Toxicology.

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses.

B. van de Water, B. Ter Braak, S. Wink, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

SYSTEMIC COMPARISON OF DICLOFENAC INDUCED GENE EXPRESSION CHANGES IN DIVERSE IN VITRO AND IN VIVO MODELS AND SPECIES

G. Groothuis, J. Meerman, M. Luijten, 2014 .

Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage.

B. Water, S. Wink, S. Hiemstra, 2017, Chemical research in toxicology.

The integrated stress response‐related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability

J. Eakins, G. Callegaro, Gerhard A. Burger, 2024, Liver international : official journal of the International Association for the Study of the Liver.