Daniel Knappe

发表

Continuous Subcutaneous Delivery of Proline-Rich Antimicrobial Peptide Api137 Provides Superior Efficacy to Intravenous Administration in a Mouse Infection Model

R. Hoffmann, Rico Schmidt, D. Knappe, 2019, Front. Microbiol..

In vivo Efficacy and Pharmacokinetics of Optimized Apidaecin Analogs

R. Hoffmann, Rico Schmidt, D. Knappe, 2017, Front. Chem..

Identification of Api88 Binding Partners in Escherichia coli Using a Photoaffinity-Cross-Link Strategy and Label-Free Quantification.

R. Hoffmann, D. Volke, D. Knappe, 2015, Journal of proteome research.

Minibactenecins ChBac7.Nα and ChBac7. Nβ - Antimicrobial Peptides from Leukocytes of the Goat Capra hircus.

R. Hoffmann, V. Kokryakov, O. Shamova, 2016, Acta naturae.

Insect-derived proline-rich antimicrobial peptides kill bacteria by inhibiting bacterial protein translation at the 70S ribosome.

R. Hoffmann, D. Volke, N. Sträter, 2014, Angewandte Chemie.

Structural identification of DnaK binding sites within bovine and sheep bactenecin Bac7.

R. Hoffmann, M. Zahn, D. Knappe, 2014, Protein and peptide letters.

Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum

R. Hoffmann, D. Knappe, Roland Böttger, 2017, PloS one.

Epitope mapping of monoclonal antibody HPT-101: a study combining dynamic force spectroscopy, ELISA and molecular dynamics simulations

F. Kremer, R. Hoffmann, S. Angioletti-Uberti, 2015, Physical biology.

N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa

R. Hoffmann, P. Seibel, E. Veldhuizen, 2016, Front. Cell Dev. Biol..

Structure-activity relationship study using peptide arrays to optimize Api137 for an increased antimicrobial activity against Pseudomonas aeruginosa.

R. Hoffmann, D. Knappe, Martin E. Bluhm, 2015, European journal of medicinal chemistry.

Short Proline‐Rich Antimicrobial Peptides Inhibit Either the Bacterial 70S Ribosome or the Assembly of its Large 50S Subunit

R. Hoffmann, D. Knappe, Andor Krizsan, 2015, Chembiochem : a European journal of chemical biology.

Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

Ralf Hoffmann, Laszlo Otvos, John Wade, 2011, BMC biotechnology.

Insect-derived short proline-rich and murine cathelicidin-related antimicrobial peptides act synergistically on Gram-negative bacteria in vitro.

R. Hoffmann, D. Knappe, N. Herth, 2016, Future medicinal chemistry.

Blood-brain barrier transport of short proline-rich antimicrobial peptides.

K. Peremans, R. Hoffmann, E. Wynendaele, 2014, Protein and peptide letters.

Identification of New Resistance Mechanisms in Escherichia coli against Apidaecin 1b Using Quantitative Gel- and LC-MS-Based Proteomics.

R. Hoffmann, D. Volke, Rico Schmidt, 2016, Journal of proteome research.

Structural studies on the forward and reverse binding modes of peptides to the chaperone DnaK.

R. Hoffmann, N. Sträter, M. Zahn, 2013, Journal of molecular biology.

Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens.

R. Hoffmann, O. Nolte, D. Knappe, 2010, Journal of medicinal chemistry.

Optimization of adiponectin‐derived peptides for inhibition of cancer cell growth and signaling

S. Lovas, I. Kovalszky, R. Hoffmann, 2015, Biopolymers.

Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens.

R. Hoffmann, N. Sträter, G. Köhler, 2012, ACS chemical biology.

Development of a pharmacologically improved peptide agonist of the leptin receptor.

R. Hoffmann, L. Otvos, J. Wade, 2008, Biochimica et biophysica acta.

Simultaneous Chromatographic Quantitation of Drug Substance and Excipients in Nanoformulations Using a Combination of Evaporative Light Scattering and Absorbance Detectors.

R. Hoffmann, Shyh-Dar Li, D. Knappe, 2022, Molecular pharmaceutics.

Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections.

I. Kovalszky, R. Bonomo, R. Hoffmann, 2010, The Journal of antimicrobial chemotherapy.

Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae and Pseudomonas aeruginosa

R. Hoffmann, D. Knappe, Luzia Holfeld, 2018, The Journal of antimicrobial chemotherapy.

Correlating uptake and activity of proline-rich antimicrobial peptides in Escherichia coli

R. Hoffmann, D. Knappe, Luzia Holfeld, 2017, Analytical and Bioanalytical Chemistry.

Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System

R. Hoffmann, D. Knappe, Andor Krizsan, 2015, Antimicrobial Agents and Chemotherapy.

Novel Apidaecin 1b Analogs with Superior Serum Stabilities for Treatment of Infections by Gram-Negative Pathogens

R. Hoffmann, D. Knappe, P. Czihal, 2012, Antimicrobial Agents and Chemotherapy.

Intracellular Toxicity of Proline-Rich Antimicrobial Peptides Shuttled into Mammalian Cells by the Cell-Penetrating Peptide Penetratin

Ralf Hoffmann, Peter Seibel, R. Hoffmann, 2012, Antimicrobial Agents and Chemotherapy.

Bactericidal oncocin derivatives with superior serum stabilities.

R. Hoffmann, D. Knappe, Natalja Kabankov, 2011, International journal of antimicrobial agents.

iSPAAC: Isomer-Free Generation of a Bcl-xL -Inhibitor in Living Cells.

R. Hoffmann, T. Berg, D. Knappe, 2018, Chemistry.

Antimicrobial and Antibiofilm Activity of UP-5, an Ultrashort Antimicrobial Peptide Designed Using Only Arginine and Biphenylalanine

R. Hoffmann, Qosay A. E. Al-Balas, A. Almaaytah, 2018, Pharmaceuticals.

Novel Apidaecin 1 b Analogs with Superior Serum Stabilities for Treatment of Infections by Gram-Negative Pathogens

D. Knappe, P. Czihal, S. Fritsche, 2012 .

Immunogenicity and pharmacokinetics of short, proline-rich antimicrobial peptides.

R. Hoffmann, D. Singer, D. Knappe, 2015, Future medicinal chemistry.

Oncocin derivative Onc72 is highly active against Escherichia coli in a systemic septicaemia infection mouse model.

R. Hoffmann, G. Köhler, U. Müller, 2012, The Journal of antimicrobial chemotherapy.

Isolation, purification and de novo sequencing of TBD‐1, the first beta‐defensin from leukocytes of reptiles

R. Hoffmann, C. Stegemann, D. Knappe, 2009, Proteomics.

Proline-rich Antimicrobial Peptides Optimized for Binding to Escherichia coli Chaperone DnaK.

Nicholas Y. Palermo, S. Lovas, R. Hoffmann, 2016, Protein and peptide letters.

Effect of antimicrobial peptides from Apis mellifera hemolymph and its optimized version Api88 on biological activities of human monocytes and mast cells

R. Hoffmann, S. Hauschildt, Erik Schilling, 2013, Innate immunity.

Absence of in vitro innate immunomodulation by insect‐derived short proline‐rich antimicrobial peptides points to direct antibacterial action in vivo

R. Hoffmann, D. Knappe, S. Fritsche, 2012, Journal of peptide science : an official publication of the European Peptide Society.

Intracellular Toxicity of Proline-Rich Antimicrobial Peptides Shuttled into Mammalian Cells by the Cell-Penetrating Peptide Penetratin

R. Hoffmann, P. Seibel, Anne Hansen, 2012, Antimicrobial Agents and Chemotherapy.

Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus

R. Mikut, R. Hoffmann, K. Hilpert, 2015, Amino Acids.

Ribosomal Target‐Binding Sites of Antimicrobial Peptides Api137 and Onc112 Are Conserved among Pathogens Indicating New Lead Structures To Develop Novel Broad‐Spectrum Antibiotics

R. Hoffmann, D. Volke, N. Sträter, 2020, Chembiochem : a European journal of chemical biology.

Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics against Cryptococcus neoformans

S. Fritsche, A. Brakel, Andor Krizsan, 2024, Frontiers in microbiology.

Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High‐Resolution Structure of the Oncocin‐DnaK Complex

R. Hoffmann, N. Sträter, M. Zahn, 2011, Chembiochem : a European journal of chemical biology.

Oncocin Onc72 is efficacious against antibiotic‐susceptible Klebsiella pneumoniae ATCC 43816 in a murine thigh infection model

R. Hoffmann, D. Knappe, K. Adermann, 2015, Biopolymers.

In Vitro Properties and Pharmacokinetics of Temporarily PEGylated Onc72 Prodrugs

D. Volke, Shyh-Dar Li, Roland Böttger, 2023, Advanced healthcare materials.

Agonists and partial antagonists acting on the leptin--leptin receptor interface.

L. Otvos, J. Wade, S. Cascio, 2009, Advances in experimental medicine and biology.

Easy Strategy To Protect Antimicrobial Peptides from Fast Degradation in Serum

Kai Hilpert, Ralf Hoffmann, Petra Henklein, 2010, Antimicrobial Agents and Chemotherapy.