L. R. Thomas

发表

Discovery and Structure-Based Optimization of Potent and Selective WD repeat domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.

S. Fesik, R. Coffey, M. Inoue, 2019, Journal of medicinal chemistry.

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

Qi Sun, Zhongming Zhao, Zhongming Zhao, 2015, Molecular cell.

MYC and Chromatin

W. Tansey, L. Thomas, L. R. Thomas, 2015 .

Interaction with WDR 5 Pro motes Target Gene Recognition and Tumorigenesis by MYC Graphical

Zhongming Zhao, E. Olejniczak, S. Fesik, 2015 .

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

S. Fesik, M. Hall, Qi Liu, 2019, Cell reports.

Dynamic regulation of antigen receptor gene assembly.

E. Oltz, L. Thomas, Robin Milley Cobb, 2009, Advances in experimental medicine and biology.

Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608

T. Aune, E. Oltz, L. Thomas, 2006, Nature Immunology.

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

Qi Liu, C. M. Eischen, J. McLean, 2021, eLife.

Discovery and Structure-Based optimization of potent and selective WDR5 inhibitors containing a dihydroisoquinolinone bicyclic core

S. Fesik, R. Coffey, J. Sai, 2020 .

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

S. Fesik, Qi Liu, C. M. Eischen, 2019, Proceedings of the National Academy of Sciences.

The C-terminal Tails of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas Receptors Have Opposing Functions in Fas-associated Death Domain (FADD) Recruitment and Can Regulate Agonist-specific Mechanisms of Receptor Activation*

A. Thorburn, John Calvin Reed, Ronald L. Johnson, 2004, Journal of Biological Chemistry.

Direct Binding of Fas-associated Death Domain (FADD) to the Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor DR5 Is Regulated by the Death Effector Domain of FADD*

A. Thorburn, John Calvin Reed, F. Salsbury, 2004, Journal of Biological Chemistry.

Proteolytic control of the oncoprotein transcription factor Myc.

W. Tansey, L. Thomas, L. R. Thomas, 2011, Advances in cancer research.

5-Oxo-ETE analogs and the proliferation of cancer cells.

M. Willingham, C. Paumi, S. Cramer, 2005, Biochimica et biophysica acta.

The MYC-WDR5 Nexus and Cancer.

Audra M. Foshage, W. Tansey, L. Thomas, 2015, Cancer research.

The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm

A. Thorburn, M. Morgan, L. Bender, 2005, Cell Death and Differentiation.

Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue

J. Pietenpol, B. Lehmann, S. Morris, 2017, BMC Cancer.

WIN site inhibition disrupts a subset of WDR5 function

S. Fesik, D. Flaherty, Qi Liu, 2022, Scientific Reports.

A common functional consequence of tumor-derived mutations within c-MYC

S. Lowe, C. Scuoppo, W. Tansey, 2014, Oncogene.

Regulation of FADD death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen

D. Stillman, A. Thorburn, L. Thomas, 2002 .

Regulation of Fas-associated Death Domain Interactions by the Death Effector Domain Identified by a Modified Reverse Two-hybrid Screen*

D. Stillman, A. Thorburn, L. Thomas, 2002, Journal of Biological Chemistry.

Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC inhibitors using fragment-based methods and structure-based design.

E. Olejniczak, S. Fesik, A. Waterson, 2020, Journal of medicinal chemistry.

Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes1

M. Reth, Y. Shinkai, E. Hobeika, 2008, The Journal of Immunology.

An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells

A. Thorburn, A. Brothman, J. Thorburn, 2001, Cell Death and Differentiation.

Tumor-derived Mutations in the TRAIL Receptor DR5 Inhibit TRAIL Signaling through the DR4 Receptor by Competing for Ligand Binding*

A. Thorburn, P. Clark, J. Thorburn, 2007, Journal of Biological Chemistry.

Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells.

A. Thorburn, S. Cramer, J. Thorburn, 2005, Molecular biology of the cell.

Targeting MYC through WDR5

S. Fesik, C. M. Eischen, C. Adams, 2020, Molecular & cellular oncology.

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Protein-Protein Interaction.

S. Fesik, A. Waterson, O. Rossanese, 2019, Journal of medicinal chemistry.

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1

Qi Liu, C. M. Eischen, S. Sherrod, 2020, bioRxiv.

Mutations in the Pho2 (Bas2) Transcription Factor That Differentially Affect Activation with Its Partner Proteins Bas1, Pho4, and Swi5*

D. Stillman, R. Rolfes, Lance R Thomas, 2002, The Journal of Biological Chemistry.

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

E. Olejniczak, S. Fesik, C. M. Eischen, 2015, Molecular cell.

Interaction of MYC with Host Cell Factor-1 is meditated by the evolutionarily-conserved Myc box IV motif

C. M. Eischen, Bethany A. Carboneau, Audra M. Foshage, 2015, Oncogene.

pRS yeast vectors with a LYS2 marker.

D. Stillman, A. Thorburn, P. Eriksson, 2004, BioTechniques.