G. McGown

发表

Alkylated DNA damage flipping bridges base and nucleotide excision repair

John A Tainer, Oliver Fleck, J. Tainer, 2009, Nature.

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

Aaron S. Gajadhar, K. Aldape, J. Sarkaria, 2012, The Journal of clinical investigation.

Quantitative trait locus analysis reveals two intragenic sites that influence O 6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells

S. Lewis, P. Barber, G. Margison, 2005 .

Low rate of TP53 germline mutations in breast cancer/sarcoma families not fulfilling classical criteria for Li-Fraumeni syndrome

D. Evans, J. Varley, J. Birch, 2002, Journal of medical genetics.

Characterization of germline TP53 splicing mutations and their genetic and functional analysis

J. Varley, J. Boyle, J. Birch, 2001, Oncogene.

Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors.

D. Evans, J. Varley, G. Margison, 1999, American journal of human genetics.

Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families.

D. Evans, J. Varley, M. Santibanez-Koref, 1997, Cancer research.

Allelic imbalance of chromosome 6q in ovarian tumours.

M. Santibanez-Koref, Y. Hey, J. Boyle, 1995, British Journal of Cancer.

Proximal 6q, a region showing allele loss in primary breast cancer.

M. Santibanez-Koref, Y. Hey, J. Boyle, 1995, British Journal of Cancer.

A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours

J. Larkin, M. Gore, P. Lorigan, 2011, British Journal of Cancer.

Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

J. Tainer, M. Santibanez-Koref, G. Margison, 2012, Molecular cell.

Genetic and cytogenetic studies in inherited cancer: Li Fraumeni syndrome

D. Evans, J. Varley, J. Boyle, 2000 .

An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.

D. Evans, J. Varley, M. Santibanez-Koref, 1995, Journal of medical genetics.

Identification of a rare polymorphism in the human TP53 promoter.

J. Varley, J. Birch, M. Thorncroft, 2002, Cancer genetics and cytogenetics.

Significance of intron 6 sequence variations in the TP53 gene in Li-Fraumeni syndrome.

J. Varley, J. Birch, G. Mcgown, 2001, Cancer genetics and cytogenetics.

Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li–Fraumeni syndrome

J. Varley, J. Birch, G. Mcgown, 1999, British Journal of Cancer.

A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene

D. Evans, J. Varley, J. Birch, 1997, Oncogene.

A previously undescribed mutation within the tetramerisation domain of TP53 in a family with Li-Fraumeni syndrome.

D. Evans, J. Varley, J. Boyle, 1996, Oncogene.

Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells.

S. Lewis, P. Barber, M. Santibanez-Koref, 2005, Carcinogenesis.

Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6‐alkylguanine–DNA alkyltransferase

S. Lewis, P. Barber, M. Santibanez-Koref, 2008, International journal of cancer.

Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1

Adrian L Harris, A. Harris, A. Boddy, 2005, Clinical Cancer Research.

O6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib

P. Hersey, R. Kefford, P. Lorigan, 2009, British Journal of Cancer.

A novel TP53 splicing mutation in a Li-Fraumeni syndrome family: a patient with Wilms' tumour is not a mutation carrier.

D. Evans, J. Varley, J. Birch, 1998, British Journal of Cancer.