D. Defeo-jones

发表

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.

A. Kral, G. Hartman, H. Huber, 2008, Bioorganic & medicinal chemistry letters.

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors.

Zhijian Zhao, Craig W Lindsley, J. Huff, 2005, Bioorganic & medicinal chemistry letters.

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.

Zhijian Zhao, Craig W Lindsley, J. Huff, 2005, Bioorganic & medicinal chemistry letters.

Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity.

C. Lindsley, G. Hartman, H. Huber, 2008, Bioorganic & medicinal chemistry letters.

Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling

Hans E. Huber, Sarat Chandarlapaty, Neal Rosen, 2008, PloS one.

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Pearl S Huang, H. Huber, D. Defeo-Jones, 1991, Nature.

Mammalian and yeast ras gene products: biological function in their heterologous systems.

L. C. Robinson, D. Lowy, E. Scolnick, 1985, Science.

Expression and characterization of ras mRNAs from Saccharomyces cerevisiae

E. Scolnick, K. Tatchell, D. Defeo-Jones, 1984, Molecular and cellular biology.

Requirement of either of a pair of ras-related genes of Saccharomyces cerevisiae for spore viability

E. Scolnick, K. Tatchell, D. Defeo-Jones, 1984, Nature.

Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals

E. Scolnick, A. Papageorge, D. Defeo-Jones, 1984, Molecular and cellular biology.

E. Scolnick, D. Defeo-Jones, R. Koller, 1983, Nature.

Nucleotide sequence of two rasH related-genes isolated from the yeast Saccharomyces cerevisiae.

E. Scolnick, D. Defeo-Jones, R. Koller, 1984, Nucleic acids research.

Tumors secreting human TNF/cachectin induce cachexia in mice

A. Oliff, D. Martinez, D. Defeo-Jones, 1987, Cell.

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members.

C. Lindsley, K. Leander, H. Huber, 2005, Molecular cancer therapeutics.

Assignment of three rat cellularRAS oncogenes to chromosomes 1, 4, and X

G. Levan, C. Szpirer, J. Szpirer, 1985, Somatic cell and molecular genetics.

Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.

I. Pastan, S. Stirdivant, D. Heimbrook, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Androgen ablation augments human HLA2.1‐restricted T cell responses to PSA self‐antigen in transgenic mice

M. Sanda, K. Leander, B. Hollenbeck, 2010, The Prostate.

Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts

M. Ivey-Hoyle, J. Brandsma, D. Defeo-Jones, 1993, Journal of virology.

The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy.

R. Freidinger, V. Garsky, P. Lumma, 2001, Journal of medicinal chemistry.

Nucleotide sequence of the two rat cellular rasH genes

E. Scolnick, R. Wolford, R. Ellis, 1986, Molecular and cellular biology.

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

E. Harlow, G. Edwards, D. Defeo-Jones, 1991, Molecular and cellular biology.

Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins

D. Heimbrook, A. Oliff, D. Patrick, 1989, Molecular and cellular biology.

Characterization of the retinoblastoma binding proteins RBP1 and RBP2.

K. Helin, N. Dyson, A. Fattaey, 1993, Oncogene.

Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein.

V. Garsky, D. Heimbrook, D. Patrick, 1990, The Journal of biological chemistry.

An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

Q. She, N. Rosen, K. Leander, 2010, Cancer biology & therapy.

Spontaneously transformed NRK cells lose their mitogenic response to epidermal growth factor.

D. Heimbrook, A. Oliff, R. Wegrzyn, 1989, Growth factors.

Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product

S. Stirdivant, V. Garsky, D. Heimbrook, 1992, Molecular and cellular biology.

Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha.

V. Garsky, L. Payne, J. Y. Tai, 1988, Molecular and cellular biology.

Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha

V. Garsky, L. Payne, J. Y. Tai, 1988 .

The Prostate 70 : 1002 ^ 1011 ( 2010 ) AndrogenAblationAugmentsHuman HLA 2 . 1-RestrictedT cell Responses to PSASelf-Antigen inTransgenicMice

M. Sanda, K. Leander, B. Hollenbeck, 2010 .

Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.

Jun Liang, E. Hu, P. Prasit, 2009, Bioorganic & medicinal chemistry letters.

Breast tumor cells withPI3Kmutation orHER2amplification are selectively addicted to Akt signaling.

S. Chandarlapaty, Q. She, N. Rosen, 2009 .

A peptide–doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

R. Freidinger, V. Garsky, P. Lumma, 2000, Nature Medicine.

Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells

R. Wegrzyn, D. Defeo-Jones, A. Oliff, 1991, Molecular and cellular biology.

Design and Synthesis of a Selective PSA Cleavable Peptide-Doxorubicin Prodrug Which Targets PSA Positive Tumor Cells

R. Freidinger, V. Garsky, P. Lumma, 2001 .

PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites.

V. Garsky, J. Lin, A. Oliff, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Development of pyridopyrimidines as potent Akt1/2 inhibitors.

A. Kral, G. Hartman, H. Huber, 2008, Bioorganic & medicinal chemistry letters.

Substitution of lysine for arginine at position 42 of human transforming growth factor-alpha eliminates biological activity without changing internal disulfide bonds

J. Y. Tai, R. Wegrzyn, M. W. Riemen, 1989, Molecular and cellular biology.

Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.

Kathleen Haskell, K. Leander, G. Hartman, 2008, Bioorganic & medicinal chemistry letters.

Rapid assembly of diverse and potent allosteric Akt inhibitors.

A. Kral, N. Kohl, G. Hartman, 2008, Bioorganic & medicinal chemistry letters.

Abstract #3714: In vitro and in vivo antitumor activities of MK-2206, a new allosteric Akt inhibitor

P. Majumder, K. Leander, H. Hatch, 2009 .

Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product.

M. Ivey-Hoyle, D. Defeo-Jones, K. Haskell, 1993, The Journal of general virology.

Characterization of functional HPV-16 E7 protein produced in Escherichia coli.

D. Heimbrook, K. Zhang, A. Oliff, 1992, The Journal of biological chemistry.