N. Fawzi

发表

CLAMP and Zelda function together to promote Drosophila zygotic genome activation

Nicolas L. Fawzi, E. Larschan, Mary Mckenney, 2021, eLife.

CLAMP and Zelda function together as pioneer transcription factors to promote Drosophila zygotic genome activation

Nicolas L. Fawzi, E. Larschan, Mary Mckenney, 2020, bioRxiv.

TDP-43 α-helical structure tunes liquid–liquid phase separation and function

Nicolas L. Fawzi, Young C. Kim, J. Mittal, 2020, Proceedings of the National Academy of Sciences.

Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity

Nicolas L. Fawzi, R. Cole, F. Shewmaker, 2017, The EMBO journal.

Atomic resolution dynamics on the surface of amyloid β protofibrils probed by solution NMR

Nicolas L. Fawzi, G. Clore, Jinfa Ying, 2011, Nature.

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

Nicolas L. Fawzi, Anastasia C. Murthy, M. Naik, 2020, The EMBO journal.

SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins.

Nicolas L. Fawzi, Anastasia C. Murthy, M. Naik, 2020, bioRxiv.

Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR

Nicolas L. Fawzi, G. Clore, Jinfa Ying, 2013, Proceedings of the National Academy of Sciences.

Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway

Eric N. Anderson, Nicolas L. Fawzi, D. A. Bosco, 2021, Nature Neuroscience.

The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy

Nicolas L. Fawzi, Anastasia C. Murthy, N. Fawzi, 2020, The Journal of Biological Chemistry.

Structure and dynamics of the Abeta(21-30) peptide from the interplay of NMR experiments and molecular simulations.

Jory Z. Ruscio, Nicolas L. Fawzi, D. Wemmer, 2008, Journal of the American Chemical Society.

Protein Phase Separation: A New Phase in Cell Biology.

Nicolas L. Fawzi, P. Tompa, F. Rousseau, 2018, Trends in cell biology.

Reversible Kinetic Trapping of FUS Biomolecular Condensates

Nicolas L. Fawzi, Anastasia C. Murthy, J. Mittal, 2021, Advanced science.

Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis

Nicolas L. Fawzi, Zhijin Wu, A. Hart, 2019, Neuroscience.

An enhancer sequence in the intrinsically disordered region of FtsZ promotes polymer‐guided substrate processing by ClpXP protease

Nicolas L. Fawzi, Marissa G. Viola, Jodi L. Camberg, 2022, Protein science : a publication of the Protein Society.

An enhancer sequence in the intrinsically disordered region of the essential cell division protein FtsZ promotes conformation-guided substrate processing by ClpXP in Escherichia coli

Nicolas L. Fawzi, Marissa G. Viola, Jodi L. Camberg, 2021, bioRxiv.

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration

Nicolas L. Fawzi, A. Hart, J. Mittal, 2020, The EMBO journal.

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning & reduces neurodegeneration

Nicolas L. Fawzi, A. Hart, J. Mittal, 2020, bioRxiv.

Protofibril assemblies of the arctic, Dutch, and Flemish mutants of the Alzheimer's Abeta1-40 peptide.

Nicolas L. Fawzi, K. Kohlstedt, Yuka Okabe, 2008, Biophysical journal.

N‐terminal acetylation modestly enhances phase separation and reduces aggregation of the low‐complexity domain of RNA‐binding protein fused in sarcoma

Nicolas L. Fawzi, Anastasia C. Murthy, F. Shewmaker, 2021, Protein science : a publication of the Protein Society.

Kinetics of amyloid beta monomer-to-oligomer exchange by NMR relaxation.

Nicolas L. Fawzi, G. Clore, Jinfa Ying, 2010, Journal of the American Chemical Society.

Kinetics of Amyloid ! Monomer-to-Oligomer Exchange by NMR Relaxation

Nicolas L. Fawzi, G. Clore, Jinfa Ying, 2010 .

A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

Nicolas L. Fawzi, F. Shewmaker, T. Mittag, 2018, The EMBO journal.

ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.

Nicolas L. Fawzi, J. Mittal, Gül H. Zerze, 2016, Structure.

Determining the critical nucleus and mechanism of fibril elongation of the Alzheimer's Abeta(1-40) peptide.

Eng-Hui Yap, Yuka Okabe, T. Head‐Gordon, 2007, Journal of molecular biology.

Membrane bending by protein phase separation

Nicolas L. Fawzi, P. Rangamani, H. Alimohamadi, 2020, Proceedings of the National Academy of Sciences.

Automated sequence- and stereo-specific assignment of methyl-labeled proteins by paramagnetic relaxation and methyl–methyl nuclear overhauser enhancement spectroscopy

Nicolas L. Fawzi, G. Clore, V. Venditti, 2011, Journal of biomolecular NMR.

Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads

Nicolas L. Fawzi, Anastasia C. Murthy, J. Mittal, 2021, Nature Structural & Molecular Biology.

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II.

Nicolas L. Fawzi, Nicolas L Fawzi, Kathleen A Burke, 2015, Molecular cell.

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

Nicolas L. Fawzi, J. Ule, N. Luscombe, 2021, Cell.

TDP-43 α-helical structure tunes liquid–liquid phase separation and function

Nicolas L. Fawzi, Young C. Kim, J. Mittal, 2019, Proceedings of the National Academy of Sciences.

Molecular interactions underlying liquid-liquid phase separation of the FUS low complexity domain

Nicolas L. Fawzi, Anastasia C. Murthy, J. Mittal, 2019, Nature Structural & Molecular Biology.

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Seung Joong Kim, Nicolas L. Fawzi, A. Sali, 2018, Cell.

Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.

Nicolas L. Fawzi, J. Mittal, K. Burke, 2018, Molecular cell.

Homogeneous and heterogeneous tertiary structure ensembles of amyloid-β peptides.

Nicolas L. Fawzi, D. Wemmer, T. Head-Gordon, 2011, Biochemistry.

Biophysical studies of phase separation integrating experimental and computational methods.

Nicolas L. Fawzi, J. Mittal, S. Parekh, 2021, Current opinion in structural biology.

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

Eric N. Anderson, Nicolas L. Fawzi, Anastasia C. Murthy, 2019, bioRxiv.

Epigenetic Cell Fate in Candida albicans is Controlled by Transcription Factor Condensates Acting at Super-Enhancer-Like Elements

Ilya J. Finkelstein, Nicolas L. Fawzi, Aaron D Hernday, 2020, Nature Microbiology.

Differential Occupancy of Two GA-Binding Proteins Promotes Targeting of the Drosophila Dosage Compensation Complex to the Male X Chromosome

Nicolas L. Fawzi, M. Bulyk, M. Tolstorukov, 2018, Cell reports.

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain.

Nicolas L. Fawzi, J. Sedivy, M. Naik, 2021, Biophysical journal.

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain

J. Sedivy, Guoping Li, M. Naik, 2020, bioRxiv.

A synergy between site-specific and transient interactions drives the phase separation of a disordered, low-complexity domain.

J. Mittal, Priyesh Mohanty, Azamat Rizuan, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Molecular details of protein condensates probed by microsecond-long atomistic simulations

Nicolas L. Fawzi, R. Best, Wenwei Zheng, 2020, bioRxiv.

A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data

Nicolas L. Fawzi, G. Clore, T. Kálai, 2011, Journal of biomolecular NMR.

Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis

Eric T. Wang, Nicolas L. Fawzi, E. Wang, 2018, The EMBO journal.

Mechanistic details of a protein–protein association pathway revealed by paramagnetic relaxation enhancement titration measurements

G Marius Clore, Nicolas L. Fawzi, Nicolas L Fawzi, 2010, Proceedings of the National Academy of Sciences.

Physiological, Pathological, and Targetable Membraneless Organelles in Neurons

Nicolas L. Fawzi, Veronica H. Ryan, N. Fawzi, 2019, Trends in Neurosciences.

EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons

Nicolas L. Fawzi, Anastasia C. Murthy, J. Fallon, 2019, Biology Open.

The FXR2P low complexity domain drives assembly of multiple fibril types with differing ribosome association in neurons

Nicolas L. Fawzi, Anastasia C. Murthy, J. Fallon, 2018, bioRxiv.

The SH3 domain of Fyn kinase interacts with and induces liquid–liquid phase separation of the low-complexity domain of hnRNPA2

Nicolas L. Fawzi, Veronica H. Ryan, Joshua Amaya, 2018, The Journal of Biological Chemistry.

Synthesis and Characterization of a Magnetically Active 19F Molecular Beacon.

Nicolas L. Fawzi, E. Darling, M. Dempsey, 2018, Bioconjugate chemistry.

Contrasting disease and nondisease protein aggregation by molecular simulation.

K. Kohlstedt, Scott Brown, Eng-Hui Yap, 2008, Accounts of chemical research.

Hydrophobic potential of mean force as a solvation function for protein structure prediction.

Teresa Head-Gordon, Nicolas L. Fawzi, T. Head-Gordon, 2007, Structure.

Phase separation in fungi

Nicolas L. Fawzi, R. Bennett, C. Frazer, 2023, Nature Microbiology.

The C-Terminal Threonine of Aβ43 Nucleates Toxic Aggregation via Structural and Dynamical Changes in Monomers and Protofibrils

Nicolas L. Fawzi, Alexander E Conicella, N. Fawzi, 2014, Biochemistry.

Homogeneous and heterogeneous tertiary structure ensembles of amyloid-β peptides.

D. Wemmer, P. Nerenberg, Aaron H. Phillips, 2011, Biochemistry.

Structure and dynamics of the Abeta(21-30) peptide from the interplay of NMR experiments and molecular simulations.

Jory Z. Ruscio, D. Wemmer, Aaron H. Phillips, 2008, Journal of the American Chemical Society.

Refining All-Atom Protein Force Fields for Polar-Rich, Prion-like, Low-Complexity Intrinsically Disordered Proteins.

Nicolas L. Fawzi, J. Mittal, Wai Shing Tang, 2020, The journal of physical chemistry. B.

How hot? Systematic convergence of the replica exchange method using multiple reservoirs

Teresa Head-Gordon, Jory Z. Ruscio, Nicolas L. Fawzi, 2009, J. Comput. Chem..

Fibril formation and ordering of disordered FUS LC driven by hydrophobic interactions

Nicolas L. Fawzi, Anastasia C. Murthy, M. Bonn, 2023, Nature Chemistry.

Probing exchange kinetics and atomic resolution dynamics in high-molecular-weight complexes using dark-state exchange saturation transfer NMR spectroscopy

Nicolas L. Fawzi, G. Clore, Jinfa Ying, 2012, Nature Protocols.

Characterizing methyl-bearing side chain contacts and dynamics mediating amyloid β protofibril interactions using ¹³C(methyl)-DEST and lifetime line broadening.

Nicolas L. Fawzi, G. Clore, Jinfa Ying, 2014, Angewandte Chemie.

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

Laura R. Ganser, Anastasia C. Murthy, S. Myong, 2023, bioRxiv.

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II.

K. Burke, Christy L Rhine, Abigail M. Janke, 2015, Molecular cell.

A coarse-grained model for position-specific effects of post-translational modifications on disordered protein phase separation.

Nicolas L. Fawzi, Young C. Kim, J. Mittal, 2021, Biophysical journal.

A predictive coarse-grained model for position-specific effects of post-translational modifications on disordered protein phase separation

J. Mittal, G. Dignon, T. M. Perdikari, 2020, bioRxiv.

Interactions between FUS and the C-terminal domain of Nup62 are sufficient for their co-phase separation into amorphous assemblies.

James B. Munro, Nicolas L. Fawzi, Anastasia C. Murthy, 2023, Journal of molecular biology.

Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid–liquid phase separation and aggregation

Nicolas L. Fawzi, V. Venditti, Balabhadra Khatiwada, 2020, Nucleic acids research.

Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin—resistant Staphylococcus aureus

Nicolas L. Fawzi, Bumsup Kwon, M. Gilmore, 2018, Scientific Reports.

Automated sequence- and stereo-specific assignment of methyl-labeled proteins by paramagnetic relaxation and methyl–methyl nuclear overhauser enhancement spectroscopy

G. Clore, V. Venditti, N. Fawzi, 2011, Journal of biomolecular NMR.

A complex network of interdomain interactions underlies the conformational ensemble of monomeric TDP‐43 and modulates its phase behavior

J. Mittal, Priyesh Mohanty, Azamat Rizuan, 2023, Protein science : a publication of the Protein Society.

Structural details of helix-mediated TDP-43 C-terminal domain multimerization

J. Mittal, Priyesh Mohanty, Yuna M. Ayala, 2024, bioRxiv.

Differential Occupancy of Two GA-Binding Proteins Promotes Targeting of the Drosophila Dosage Compensation Complex to the Male X Chromosome

M. Bulyk, M. Tolstorukov, E. Larschan, 2018, Cell reports.

An efficient protocol for incorporation of an unnatural amino acid in perdeuterated recombinant proteins using glucose-based media

Nicolas L. Fawzi, G. Clore, V. Venditti, 2012, Journal of biomolecular NMR.

An efficient protocol for incorporation of an unnatural amino acid in perdeuterated recombinant proteins using glucose-based media

G. Clore, V. Venditti, N. Fawzi, 2012, Journal of Biomolecular NMR.

Dual DNA/RNA-binding factor regulates dynamics of hnRNP splicing condensates

A. M. Conard, Pranav Mahableshwarkar, Smriti Vaidyanathan, 2024, bioRxiv.

Phase separation in biology and disease—a symposium report

Luke E. Berchowitz, Nicolas L. Fawzi, R. Pappu, 2019, Annals of the New York Academy of Sciences.

Protein quality and miRNA slicing get into phase

Nicolas L. Fawzi, T. Mittag, N. Fawzi, 2018, Nature Cell Biology.

The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation

Nicolas L. Fawzi, F. Shewmaker, R. Kortum, 2021, bioRxiv.

Molecular insights into the effect of alkanediols on FUS liquid-liquid phase separation

Nicolas L. Fawzi, Anastasia C. Murthy, T. M. Perdikari, 2022, bioRxiv.