Anass Chiki

发表

A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research

H. Lashuel, A. Chiki, Senthil T. Kumar, 2019, bioRxiv.

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

N. Guex, H. Lashuel, C. Iseli, 2022, npj Parkinson's Disease.

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

H. Lashuel, A. Chiki, Ritwik Burai, 2015, Journal of the American Chemical Society.

Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo

D. D. Di Monte, H. Lashuel, A. Chiki, 2023, bioRxiv.

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1

H. Lashuel, A. Chiki, G. Dietler, 2021, bioRxiv.

Towards deciphering the Nt17 code: How the sequence and conformation of the first 17 amino acids in Huntingtin regulate the aggregation, cellular properties and neurotoxicity of mutant Httex1

H. Lashuel, A. Chiki, G. Dietler, 2021 .

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

C. Ross, J. Auwerx, M. Dragunow, 2020, The EMBO journal.

TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington’s disease

C. Ross, J. Auwerx, A. Caricasole, 2019, bioRxiv.

Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils.

H. Lashuel, A. Chiki, Driss Boudeffa, 2022, Journal of the American Chemical Society.

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

H. Lashuel, F. Sobott, A. De Simone, 2020, Nature Communications.

Exploring the role of post‐translational modifications in regulating α‐synuclein interactions by studying the effects of phosphorylation on nanobody binding

C. Dobson, A. Mittermaier, M. Vendruscolo, 2018, Protein science : a publication of the Protein Society.

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

H. Lashuel, A. Chiki, Mohamed Fares, 2018, The Journal of Biological Chemistry.

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

J. Marsh, A. Caricasole, H. Lashuel, 2017, Proceedings of the National Academy of Sciences.

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

A. Pastore, H. Lashuel, A. Chiki, 2017, Angewandte Chemie.

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

H. Lashuel, D. Eliezer, A. Chiki, 2020, The Journal of Biological Chemistry.

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

J. Wityak, H. Lashuel, C. Scheich, 2021, Scientific Reports.

Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology

C. Sandi, H. Lashuel, A. Chiki, 2019, Neurobiology of Aging.

The structural basis of huntingtin (Htt) fibril polymorphism, revealed by cryo-EM of exon 1 Htt fibrils

H. Lashuel, A. Chiki, Driss Boudeffa, 2021, bioRxiv.

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1.

H. Lashuel, A. Chiki, G. Dietler, 2021, Journal of molecular biology.

The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions

G. Knott, C. Strand, M. Citron, 2018, bioRxiv.

Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

F. Stellacci, A. Alexander-Katz, H. Lashuel, 2019, Proceedings of the National Academy of Sciences.

Chronic corticosterone enhancement aggravates alpha-synuclein brain spreading pathology and substantia nigra neurodegeneration in mice

C. Sandi, H. Lashuel, A. Chiki, 2018, bioRxiv.

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

H. Lashuel, A. Chiki, G. Dietler, 2016, Scientific Reports.

Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity

H. Lashuel, F. Sobott, A. Chiki, 2019, bioRxiv.

N-terminal phosphorylation of Huntingtin: A molecular switch for regulating Htt aggregation, helical conformation, internalization and nuclear targeting

H. Lashuel, A. Chiki, Mohamed Fares, 2018, bioRxiv.

Deep Learning-Assisted Single-Molecule Detection of Protein Post-translational Modifications with a Biological Nanopore

Lucien F. Krapp, Pedro Magalhães, J. F. Bada Juarez, 2023, bioRxiv.

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

H. Lashuel, M. dal Peraro, A. Chiki, 2021, bioRxiv.

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

H. Lashuel, Ritwik Burai, Anass Chiki, 2015, Journal of the American Chemical Society.

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

H. Lashuel, A. Reif, A. Chiki, 2018, Journal of visualized experiments : JoVE.