David Kung‐Chun Chiu

发表

Neutrophil-activating therapy for the treatment of cancer.

Nathan E. Reticker-Flynn, E. Engleman, Xiangyue Zhang, 2023, Cancer cell.

CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma

D. Cescon, P. Khong, I. Ng, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3.

I. Ng, C. C. Wong, Lai Wei, 2017, Journal of hepatology.

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

Lai Wei, Jialing Shen, Chun-Ming Wong, 2018, Hepatology.

Assessment of Stabilization and Activity of the HIFs Important for Hypoxia-Induced Signalling in Cancer Cells.

C. C. Wong, D. K. Chiu, David Kung-Chun Chiu, 2019, Methods in molecular biology.

Using mouse liver cancer models based on somatic genome editing to predict immune checkpoint inhibitor responses.

Yan Zhang, C. C. Wong, D. K. Chiu, 2022, Journal of hepatology.

Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma

I. Ng, C. C. Wong, Yanping Huang, 2014, Hepatology.

Switching of Pyruvate Kinase Isoform L to M2 Promotes Metabolic Reprogramming in Hepatocarcinogenesis

I. Ng, C. C. Wong, F. H. Tsang, 2014, PloS one.

Title Switching of pyruvate kinase isoform L to M 2 promotesmetabolic reprogramming in hepatocarcinogenesis

I. Ng, C. C. Wong, D. K. Chiu, 2014 .

RNA N 6-methyladenosine methyltransferase METTL 3 promotes liver cancer progression through YTHDF 2 dependent post-transcriptional silencing of SOCS 2

I. Ng, C. C. Wong, D. Ho, 2017 .

The Amot/Integrin protein complex transmits mechanical forces required for vascular expansion

T. Barker, N. Tobin, L. Holmgren, 2021, bioRxiv.

Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer

I. Ng, C. C. Wong, D. K. Chiu, 2022, Nature communications.

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

I. Ng, C. C. Wong, I. Xu, 2017, Nature Communications.

Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer

I. Ng, C. C. Wong, F. H. Tsang, 2018, Oncogenesis.

Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer.

I. Ng, C. C. Wong, Lai Wei, 2021, Cell reports.

Polo‐like kinase 4 inhibitor CFI‐400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity

D. Cescon, T. Mak, P. Khong, 2022, Hepatology.

Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma

I. Ng, C. C. Wong, F. H. Tsang, 2017, The Journal of clinical investigation.

Hypoxia induces myeloid‐derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C‐C motif) ligand 26

I. Ng, C. C. Wong, D. K. Chiu, 2016, Hepatology.

Inhibition of CMTM4 Sensitizes Cholangiocarcinoma and Hepatocellular Carcinoma to T Cell–Mediated Antitumor Immunity Through PD‐L1

I. Ng, C. C. Wong, D. K. Chiu, 2021, Hepatology communications.

Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species

I. Ng, C. C. Wong, F. H. Tsang, 2021, Hepatology.

Title Folate cycle enzyme MTHFD 1 L confers metabolic advantages inhepatocellular carcinoma

I. Ng, C. C. Wong, Derek Lee, 2022 .

Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer

I. Ng, C. C. Wong, D. K. Chiu, 2022, Nature Communications.

NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma

I. Ng, C. C. Wong, M. Wong, 2016, Clinical Cancer Research.

Transketolase counteracts oxidative stress to drive cancer development

Chun-Ming Wong, Zongwei Cai, I. Ng, 2016, Proceedings of the National Academy of Sciences.

Hepatocellular Carcinoma Cells Upregulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice.

I. Ng, T. Yau, C. C. Wong, 2020, Gastroenterology.

Induction of Oxidative Stress Through Inhibition of Thioredoxin Reductase 1 Is an Effective Therapeutic Approach for Hepatocellular Carcinoma

S. Lowe, I. Ng, C. C. Wong, 2019, Hepatology.

NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma

I. Ng, C. C. Wong, M. Wong, 2016, Clinical Cancer Research.

Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development

I. Ng, C. C. Wong, D. K. Chiu, 2023, Science advances.