Dominik Hotter

发表

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses

A. Telenti, F. Kirchhoff, P. McLaren, 2015, Retrovirology.

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

F. Kirchhoff, M. Geyer, D. Sauter, 2017, Nature Communications.

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells.

F. Kirchhoff, B. Verhasselt, F. Roesch, 2016, Cell reports.

N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

T. Noda, F. Kirchhoff, D. Standley, 2019, Nature Microbiology.

HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression

G. Schotta, F. Kirchhoff, D. Sauter, 2020, Nucleic acids research.

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

Mario Schelhaas, F. Kirchhoff, Y. Ni, 2020, PLoS pathogens.

Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread

F. Kirchhoff, C. Jolly, D. Hotter, 2020, Proceedings of the National Academy of Sciences.

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

F. Kirchhoff, M. Peeters, I. Stagljar, 2018, PLoS pathogens.

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

G. Learn, D. Fuchs, J. Billingsley, 2018, Nature Communications.

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation

C. Van Lint, F. Kirchhoff, M. Peeters, 2017, PLoS pathogens.

Modulation of viral gene expression and cellular immune responses by primate lentiviral proteins Vpu, Vpr and Nef

D. Hotter, Dominik Hotter, 2016 .

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity.

Amalio Telenti, Frank Kirchhoff, Dominik Hotter, 2016, Cell host & microbe.

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

C. Van Lint, F. Kirchhoff, B. Hahn, 2015, Cell reports.

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin.

G. Learn, P. Sharp, F. Kirchhoff, 2014, Cell host & microbe.

HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3

F. Kirchhoff, D. Sauter, D. Hotter, 2013, Journal of Virology.

A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx

B. Sitek, D. A. Megger, D. Sauter, 2018, Front. Immunol..

Interferons and beyond: Induction of antiretroviral restriction factors

F. Kirchhoff, D. Hotter, Dominik Hotter, 2017, Journal of leukocyte biology.

CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

F. Kirchhoff, B. Hahn, D. Sauter, 2020, mBio.

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.

K. Conzelmann, F. Kirchhoff, J. Münch, 2019, Cell reports.

Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1

L. Wiesmüller, F. Kirchhoff, T. Hofmann, 2020, Nature Microbiology.

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

S. Chanda, J. Fellay, F. Kirchhoff, 2019, eLife.

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.

A. Das, B. Berkhout, F. Kirchhoff, 2019, Cell host & microbe.

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

L. K. Sørensen, M. Nyegaard, F. Kirchhoff, 2017, Nature Communications.

Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins

Weiqi Wang, F. Kirchhoff, Y. Xiong, 2021, Proceedings of the National Academy of Sciences.

Emerging role of the host restriction factor tetherin in viral immune sensing.

F. Kirchhoff, D. Sauter, D. Hotter, 2013, Journal of molecular biology.

Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins

F. Kirchhoff, D. Sauter, D. Hotter, 2016, Small GTPases.

Human Cytomegalovirus Particles Treated with Specific Antibodies Induce Intrinsic and Adaptive but Not Innate Immune Responses

T. Mertens, T. Stamminger, D. Hotter, 2017, Journal of Virology.

N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

Osamu Takeuchi, Daron M Standley, Sho Miyamoto, 2019, Nature Microbiology.

A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release

F. Kirchhoff, A. Kieser, C. Kubisch, 2013, Retrovirology.

HCMV particles treated with specific antibodies induce intrinsic and adaptive 1 but not innate immune responses 2 3 Running title : HCMV-Ab induced immunity

T. Mertens, T. Stamminger, G. Frascaroli, 2017 .

Automated, label-free TCID50 assay to determine the infectious titer of virus-based therapeutics.

Daniel Hochdorfer, D. Hotter, J. Solzin, 2021, Journal of virological methods.