Maurizio Pellecchia

发表

High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.

Bainan Wu, Elisa Barile, Surya K De, 2015, Current topics in medicinal chemistry.

Solution nuclear magnetic resonance spectroscopy techniques for probing intermolecular interactions.

Maurizio Pellecchia, M. Pellecchia, 2005, Chemistry & biology.

Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL

Maurizio Pellecchia, Marilisa Leone, Thomas J. Kipps, 2004 .

NMR-based structural characterization of large protein-ligand interactions

Maurizio Pellecchia, Daniel S Sem, D. Sem, 2002, Journal of biomolecular NMR.

Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox.

Maurizio Pellecchia, Daniel S Sem, H. Villar, 2004, Chemistry & biology.

Structure- and fragment-based approaches to protease inhibition.

Maurizio Pellecchia, M. Pellecchia, Sherida L Johnson, 2006, Current topics in medicinal chemistry.

The solution structure of the bacterial HSP70 chaperone protein domain DnaK(393–507) in complex with the peptide NRLLLTG

Maurizio Pellecchia, E. Zuiderweg, M. Pellecchia, 2003, Protein science : a publication of the Protein Society.

NMR-based techniques in the hit identification and optimisation processes

Dawoon Jung, Maurizio Pellecchia, Lutz Tautz, 2004, Expert opinion on therapeutic targets.

Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules.

Bainan Wu, Maurizio Pellecchia, Martin G Pomper, 2012, Anti-cancer agents in medicinal chemistry.

A fragment-based approach for the discovery of isoform-specific p38? inhibitors

Maurizio Pellecchia, Ziming Zhang, John L. Stebbins, 2007 .

Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.

Stefan Vasile, Maurizio Pellecchia, Fabio Cerignoli, 2009, Journal of medicinal chemistry.

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

Nunzio Bottini, Maurizio Pellecchia, Tomas Mustelin, 2004, Nature Genetics.

Virtual docking approaches to protein kinase B inhibition.

Dawoon Jung, Maurizio Pellecchia, Peter J Houghton, 2005, Journal of medicinal chemistry.

Efficient synthetic inhibitors of anthrax lethal factor.

Dawoon Jung, Maurizio Pellecchia, Alex Y Strongin, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

Maurizio Pellecchia, Giovanni Solinas, Michael Karin, 2008, Proceedings of the National Academy of Sciences.

Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.

Kristiina Vuori, Maurizio Pellecchia, Lutz Tautz, 2007, Journal of medicinal chemistry.

The Nuclear Overhauser Effect in the lead identification process.

Maurizio Pellecchia, Marilisa Leone, H. Freeze, 2006, Current drug discovery technologies.

Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.

Bainan Wu, Maurizio Pellecchia, Kate Welsh, 2008, Journal of medicinal chemistry.

Structure–activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid

Maurizio Pellecchia, Marilisa Leone, John C Reed, 2006, Proceedings of the National Academy of Sciences.

Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors.

Bainan Wu, Maurizio Pellecchia, Ziming Zhang, 2007, Journal of medicinal chemistry.

A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors.

Maurizio Pellecchia, Ziming Zhang, M. Pellecchia, 2007, ACS chemical biology.

Nmr in drug discovery

Kurt Wüthrich, Maurizio Pellecchia, Daniel S. Sem, 2002, Nature Reviews Drug Discovery.

Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach.

Dawoon Jung, Maurizio Pellecchia, M. Pellecchia, 2005, Journal of medicinal chemistry.

Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.

Maurizio Pellecchia, Marilisa Leone, John C Reed, 2004, Chemistry & biology.

SAR by ILOEs: an NMR-based approach to reverse chemical genetics.

Maurizio Pellecchia, M. Pellecchia, B. Becattini, 2006, Chemistry.

Selective Incorporation of 19F‐Labeled Trp Side Chains for NMR‐Spectroscopy‐Based Ligand–Protein Interaction Studies

Maurizio Pellecchia, Marilisa Leone, Ricard A Rodriguez-Mias, 2003, Chembiochem : a European journal of chemical biology.

Luminescent silica nanobeads: characterization and evaluation as efficient cytoplasmatic transporters for T-lymphocytes.

Maurizio Pellecchia, Marilisa Leone, Fabio Cerignoli, 2007, Journal of the American Chemical Society.

Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Li Yang, Maurizio Pellecchia, Hongbin Yuan, 2009, Journal of medicinal chemistry.

A Structure-based Approach to Retinoid X Receptor-α Inhibition*

Maurizio Pellecchia, Marilisa Leone, John L. Stebbins, 2006, Journal of Biological Chemistry.

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.

Maurizio Pellecchia, Gabriel Pineda, Christian L. Barrett, 2016, Cell stem cell.

Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase.

Elisa Barile, Maurizio Pellecchia, Hongbin Yuan, 2009, Journal of medicinal chemistry.

Use of selective Trp side chain labeling to characterize protein-protein and protein-ligand interactions by NMR spectroscopy.

Maurizio Pellecchia, Ricard A Rodriguez-Mias, M. Pellecchia, 2003, Journal of the American Chemical Society.

Structural insights into substrate binding by the molecular chaperone DnaK

Shawn Y. Stevens, Maurizio Pellecchia, Lila M. Gierasch, 2000, Nature Structural Biology.

Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach.

Maurizio Pellecchia, Giuseppe Bifulco, Andrea Basso, 2009, Journal of medicinal chemistry.