Stephen Patterson

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Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

S. Wyllie, S. Patterson, Stephen Patterson, 2014, Trends in parasitology.

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease

I. Gilbert, D. Horn, L. S. Torrie, 2021, Antimicrobial agents and chemotherapy.

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

A. Fairlamb, S. Wyllie, D. Spinks, 2009, Molecular microbiology.

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase

I. Gilbert, D. Robinson, L. S. Torrie, 2022, ACS infectious diseases.

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2016, eLife.

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2018, Nature.

SELECTIVE CHEMICAL INTERVENTION IN BIOLOGICAL SYSTEMS : THE SMALL MOLECULE TOOL , ( S )-(-)-BLEBBISTATIN

Nicholas, López, Westwood, 2003 .

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2023, Journal of medicinal chemistry.

A comparative study of methylglyoxal metabolism in trypanosomatids

A. Fairlamb, S. Wyllie, N. Greig, 2009, The FEBS journal.

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Frederick R. C. Simeons, L. Stojanovski, K. Read, 2022, Journal of medicinal chemistry.

Biosynthetic studies on the tropane alkaloid hyoscyamine in Datura stramonium; hyoscyamine is stable to in vivo oxidation and is not derived from littorine via a vicinal interchange process.

D. O'Hagan, S. Patterson, Stephen Patterson, 2002, Phytochemistry.

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

K. Read, A. Fairlamb, S. Wyllie, 2010, Antimicrobial Agents and Chemotherapy.

Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

A. Fairlamb, S. Wyllie, S. Patterson, 2013, Molecular microbiology.

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

I. Gilbert, V. Yardley, B. Nare, 2021, Journal of medicinal chemistry.

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

Michael D. Urbaniak, M. Berriman, A. Fairlamb, 2015, PLoS neglected tropical diseases.

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Ian H. Gilbert, Alan H. Fairlamb, Paul G. Wyatt, 2011, Journal of medicinal chemistry.

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

Juan A. Bueren-Calabuig, I. Gilbert, A. Fairlamb, 2020, ACS infectious diseases.

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

S. Norval, K. Read, M. Berriman, 2016, PLoS pathogens.

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei

A. Fairlamb, S. Wyllie, S. Patterson, 2014, Molecular microbiology.

Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2023, Nature.

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

I. Gilbert, A. Fairlamb, M. Ferguson, 2021, Cell chemical biology.

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis.

A. Fairlamb, S. Patterson, Stephen Patterson, 2019, Current medicinal chemistry.

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2013, Antimicrobial Agents and Chemotherapy.

A core switching strategy to pyrrolo[2,3-b]quinolines and diazocino[1,2-a]indolinones.

A. Slawin, N. Westwood, Alan M. Jones, 2016, Organic & biomolecular chemistry.

Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

A. Fairlamb, S. Wyllie, S. Patterson, 2012, Antimicrobial Agents and Chemotherapy.

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2012, Science Translational Medicine.

Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)‐Blebbistatin

A. Straight, T. Mitchison, A. Slawin, 2005 .

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

David W. Gray, A. Hill, G. Drewes, 2018, Journal of medicinal chemistry.

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Michael D. Urbaniak, David W. Gray, G. Drewes, 2018, Nature.

Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates

Gourav Dey, S. Wyllie, S. Patterson, 2023, STAR protocols.

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020, Journal of medicinal chemistry.

Quinol derivatives as potential trypanocidal agents

I. Gilbert, A. Fairlamb, P. Wyatt, 2012, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of functionalised tetrahydro-β-carboline analogues as inhibitors of Toxoplasma gondii invasion.

A. Slawin, N. Westwood, G. Ward, 2009 .