Benjamin Kirsch

发表

Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence.

R. Hartmann, O. Dolezal, C. Ritter, 2013, Journal of medicinal chemistry.

Development of assay systems for the identification and functional characterization of inhibitors targeting the transcriptional regulator PqsR of Pseudomonas aeruginosa

B. Kirsch, Benjamin Kirsch, 2016 .

Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure-activity relationships.

R. Hartmann, J. D. de Jong, A. Steinbach, 2014, European journal of medicinal chemistry.

Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

R. Hartmann, J. D. de Jong, Mathias Müsken, 2012, Chemistry & biology.

From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa.

Michael P. Storz, R. Hartmann, M. Empting, 2014, Organic & biomolecular chemistry.

Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence

W. Blankenfeldt, S. Schmelz, Christine K. Maurer, 2019, ChemMedChem.

Overcoming the unexpected functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: an in vivo potent antivirulence agent targeting pqs quorum sensing.

R. Hartmann, Christine K. Maurer, A. Steinbach, 2014, Angewandte Chemie.

From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa.

Michael P. Storz, R. Hartmann, M. Empting, 2014, Organic & biomolecular chemistry.

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

Christina Zimmer, A. Steinbach, C. Henn, 2012, ACS chemical biology.