Melvin J. Yu

发表

Simulating the drug discovery pipeline: a Monte Carlo approach

Melvin J. Yu, 2012, Journal of Cheminformatics.

Druggable chemical space and enumerative combinatorics

Melvin J. Yu, 2013, Journal of Cheminformatics.

Predicting Total Clearance in Humans from Chemical Structure

Melvin J. Yu, 2010, J. Chem. Inf. Model..

Natural Product-Like Virtual Libraries: Recursive Atom-Based Enumeration

Melvin J. Yu, 2011, J. Chem. Inf. Model..

Enzymic and nonenzymic lipid peroxidation: inhibition by substituted phenoxazines

Melvin J. Yu, J. Mccowan, Jefferson Ray Mccowan, 1991 .

Novel second generation analogs of eribulin. Part III: Blood-brain barrier permeability and in vivo activity in a brain tumor model.

Melvin J. Yu, E. Schuck, Yongbo Hu, 2011, Bioorganic & medicinal chemistry letters.

Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility.

Melvin J. Yu, Yongbo Hu, Karen Tendyke, 2011, Bioorganic & medicinal chemistry letters.

Chapter 8. Treatment of Acute Myocardial Ischemia

Melvin J. Yu, P. J. Simpson, 1990 .

Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo

Melvin J. Yu, F. Gusovsky, E. Latz, 2014, Molecular Pharmacology.

Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389

Melvin J. Yu, Karen Tendyke, G. Kuznetsov, 2004, Cancer Research.

Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions.

Melvin J. Yu, M. Towle, B. Littlefield, 2011, Cancer research.

Broad spectrum preclinical antitumor activity of eribulin (Halaven(R)): optimal effectiveness under intermittent dosing conditions.

Melvin J. Yu, M. Towle, B. Littlefield, 2012, Anticancer research.

Atrial natriuretic peptide modulators: Dissociation of receptor binding and particulate guanylate cyclase activity

Melvin J. Yu, J. Mccowan, V. Wyss, 1991 .

Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B

Melvin J. Yu, B. Littlefield, Y. Kishi, 2005 .

Case History: Discovery of Eribulin (HALAVEN™), a Halichondrin B Analogue That Prolongs Overall Survival in Patients with Metastatic Breast Cancer

Melvin J. Yu, B. Littlefield, Y. Kishi, 2011 .

Antiproliferative effects of halichondrin B analog eribulin mesylate (E7389) against paclitaxel-resistant human cancer cells in vitro

Melvin J. Yu, Karen Tendyke, G. Kuznetsov, 2007 .

From micrograms to grams: scale-up synthesis of eribulin mesylate.

Melvin J. Yu, Wanjun Zheng, Boris M Seletsky, 2013, Natural product reports.

Macrocyclic ketone analogues of halichondrin B.

Lynda Tremblay, Melvin J. Yu, Yoshito Kishi, 2004, Bioorganic & medicinal chemistry letters.

Structurally simplified macrolactone analogues of halichondrin B.

Melvin J. Yu, Y. Wang, M. Towle, 2004, Bioorganic & medicinal chemistry letters.

Cationic cyclizations initiated by electrocyclic cleavage of cyclopropanes. Synthesis of lactones, tetrahydropyrans, and tetrahydrofurans

Melvin J. Yu, J. M. Morin, A. Basak, 1982 .

In Vitro and In Vivo Anticancer Activities of Synthetic Macrocyclic Ketone Analogues of Halichondrin B 1

Melvin J. Yu, Y. Wang, D. Quincy, 2001 .

A Phenothiazine Derivative Reduces Rat Brain Damage After Global or Focal Ischemia

Melvin J. Yu, J. Clemens, J. Mccowan, 1992, Stroke.

Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo.

Melvin J. Yu, E. Schuck, Yongbo Hu, 2011, Bioorganic & medicinal chemistry letters.

In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.

Melvin J. Yu, J. J. Chen, D. Quincy, 2001, Cancer research.

Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38.

Melvin J. Yu, Y. Wang, W. Christ, 2000, Bioorganic & medicinal chemistry letters.

A Phenothiazine Derivative Reduces Rat Brain Damage After Global or Focal Ischemia

Melvin J. Yu, J. Mccowan, J. Clemens, 1992, Stroke.

Phenothiazine and phenoxazine derivatives of nafazatrom. In vitro evaluation as 5-lipoxygenase and iron-dependent lipid peroxidation inhibitors.

Melvin J. Yu, P. J. Simpson, T. Lindstrom, 1992 .