K. Sivaraman

发表

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening

Alessandro Paiardini, Chiara Ruggeri, Sheena McGowan, 2015, PloS one.

The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage

D. Douek, S. Darko, J. Rossjohn, 2021, Science.

A metal ion–dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase

A. Buckle, Itamar Kass, S. McGowan, 2022, The Journal of biological chemistry.

A metal-dependent switch moderates activity of the hexameric M17 aminopeptidases

A. Buckle, Wei Yang, N. Borg, 2019 .

Role of dynamic cooperativity in the mechanism of hexameric M17 aminopeptidases

A. Buckle, Wei Yang, Itamar Kass, 2018, bioRxiv.

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.

S. McGowan, P. Scammells, R. Bamert, 2016, The Biochemical journal.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2014, Journal of medicinal chemistry.

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.

J. Whisstock, J. Dalton, G. Salvesen, 2012, Journal of molecular biology.

X‐ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti‐malarial drug targets PfA‐M1 and PfA‐M17

S. McGowan, A. Paiardini, R. Bamert, 2015, Proteins.

Synthesis and Structure − Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M 1 and M 17 Aminopeptidases from Plasmodium falciparum

J. Dalton, S. McGowan, A. Paiardini, 2013 .