Dominic J. Corkill

发表

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

B. Kemp, T. Vaughan, Elizabeth England, 2023, Scientific reports.

Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

J. Cossins, A. Gearing, J. Clements, 1997, Journal of Neuroimmunology.

Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage

J. Erjefält, J. Majithiya, D. Corkill, 2018, Scientific Reports.

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

T. Mustelin, C. Brightling, N. Bond, 2015, Nature Communications.

Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

David Baker, M. Welland, P. Vicini, 2017, Nature Communications.

Tozorakimab (MEDI3506): a dual-pharmacology anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

B. Kemp, T. Vaughan, Elizabeth England, 2022, bioRxiv.

Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview

S. Chandler, J. Clements, K. Miller, 1997, Journal of Neuroimmunology.

The synthesis of novel matrix metalloproteinase inhibitors employing the Ireland-Claisen rearrangement.

A. H. Drummond, J. Cossins, M. Whittaker, 1998, Bioorganic & medicinal chemistry letters.

Self-assembled GLP-1/glucagon peptide nanofibrils prolong inhibition of food intake

M. Welland, A. L. Gomes dos Santos, Myriam M. Ouberai, 2023, Frontiers in endocrinology.

Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis

J. Campbell, P. Tak, A. van Nieuwenhuijze, 2014, Annals of the rheumatic diseases.

Chronic pharmacological antagonism of murine GM-CSF-R-alpha does not replicate the Pulmonary Alveolar Proteinosis phenotype but does alter lung surfactant turnover.

M. Rebelatto, L. Roskos, M. Sleeman, 2021, Clinical science.

Monovalent IgG4 molecules

S. Fowler, D. Hayes, D. Corkill, 2013, mAbs.

LATE-BREAKING ABSTRACT: Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

T. Mustelin, L. Rapley, I. Scott, 2015 .

Development of a mouse model mimicking key aspects of a viral asthma exacerbation.

D. Clarke, M. Sleeman, N. H. Davis, 2014, Clinical science.

Autoantibodies are associated with disease progression in idiopathic pulmonary fibrosis

S. Chevret, V. Cottin, V. Besnard, 2023, European Respiratory Journal.