Mohamed-Ali Hakimi

发表

Apicomplexan parasites and subversion of the host cell microRNA pathway.

M. Hakimi, D. Cannella, Mohamed-Ali Hakimi, 2011, Trends in parasitology.

Reinforcement of silencing at transposons and highly repeated sequences requires the concerted action of two distinct RNA polymerases IV in Arabidopsis.

S. Lerbs-Mache, V. Colot, G. Yahubyan, 2005, Genes & development.

The aspartyl protease TgASP5 mediates the export of the Toxoplasma GRA16 and GRA24 effectors into host cells

A. Bougdour, M. Hakimi, L. Braun, 2016, Cellular microbiology.

A core–BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes

R. Shiekhattar, William Arbuthnot Sir Lane, G. Mandel, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

A. Bougdour, P. Ortet, M. Barakat, 2017, eLife.

Assembly of the Novel Five-Component Apicomplexan Multi-Aminoacyl-tRNA Synthetase Complex Is Driven by the Hybrid Scaffold Protein Tg-p43

Y. Couté, J. Murat, M. Hakimi, 2014, PloS one.

Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components.

S. Jacobsen, Claire Picart, D. Pontier, 2007, Genes & development.

A Candidate X-linked Mental Retardation Gene Is a Component of a New Family of Histone Deacetylase-containing Complexes*

R. Shiekhattar, William Arbuthnot Sir Lane, D. Speicher, 2003, The Journal of Biological Chemistry.

Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection

A. van Dorsselaer, I. Callebaut, C. Slomianny, 2016, Nature Communications.

miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain.

Michael S. Behnke, L. Sibley, A. Bougdour, 2014, Cell reports.

Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression

A. Bougdour, M. Hakimi, I. Tardieux, 2014, Cellular microbiology.

Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.

A. Bougdour, P. Ortet, M. Barakat, 2013, Cell host & microbe.

Toxoplasma GRA15 limits parasite growth in IFNγ‐activated fibroblasts through TRAF ubiquitin ligases

M. Hakimi, L. Braun, D. Mukhopadhyay, 2020, The EMBO journal.

Toxoplasma GRA15 limits parasite growth in IFNγ-activated fibroblasts through TRAF ubiquitin ligases

M. Hakimi, L. Braun, D. Mukhopadhyay, 2020, bioRxiv.

Toxoplasma Effectors Targeting Host Signaling and Transcription

L. Sibley, M. Hakimi, P. Olias, 2017, Clinical Microbiology Reviews.

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.

R. Shiekhattar, Xiaowei Chen, Neil Cooch, 2003, Molecular cell.

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

J. Gut, P. Rosenthal, A. Bougdour, 2016, Antimicrobial Agents and Chemotherapy.

3′‐end mRNA processing within apicomplexan parasites, a patchwork of classic, and unexpected players

M. Hakimi, C. Swale, Mohamed-Ali Hakimi, 2023, Wiley interdisciplinary reviews. RNA.

The Motor Protein Kinesin-1 Links Neurofibromin and Merlin in a Common Cellular Pathway of Neurofibromatosis*

R. Shiekhattar, D. Speicher, M. Hakimi, 2002, The Journal of Biological Chemistry.

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

K. Harlos, F. Tacchini-Cottier, M. Matsumoto, 2017, Structure.

Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis.

M. Hakimi, H. Kikuchi, Y. Oshima, 2015, Structure.

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole.

G. Bett, A. Bougdour, S. Sidik, 2015, Cell host & microbe.

Integrator, a Multiprotein Mediator of Small Nuclear RNA Processing, Associates with the C-Terminal Repeat of RNA Polymerase II

Mohamed-Ali Hakimi, Ali Shilatifard, A. Shilatifard, 2005, Cell.

Chromatin modifications: implications in the regulation of gene expression in Toxoplasma gondii

Mohamed-Ali Hakimi, A. Bougdour, M. Hakimi, 2010, Cellular microbiology.

Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

P. Baldacci, R. Ménard, A. Bougdour, 2009, The Journal of experimental medicine.

Histone mediated gene activation in Toxoplasma gondii.

M. Hakimi, W. Sullivan, Mohamed-Ali Hakimi, 2006, Molecular and biochemical parasitology.

Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling

G. McFadden, M. Hakimi, B. Touquet, 2019, bioRxiv.

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-kB signalling via EZH2

A. Bougdour, Y. Couté, V. Josserand, 2019, Nature Microbiology.

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

I. Coppens, A. Hehl, A. Bougdour, 2023, bioRxiv.

The Toxoplasma Dense Granule Proteins GRA 17 and GRA 23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole Graphical

G. Bett, A. Bougdour, S. Sidik, 2015 .

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

A. Bougdour, A. Palencia, M. Hakimi, 2019, Science Translational Medicine.

The developmental trajectories of Toxoplasma stem from an elaborate epigenetic rewiring.

M. Hakimi, Dayana C. Farhat, Mohamed-Ali Hakimi, 2021, Trends in parasitology.

Sustained Egr-1 Response via p38 MAP Kinase Signaling Modulates Early Immune Responses of Dendritic Cells Parasitized by Toxoplasma gondii

M. Hakimi, A. Barragan, A. L. ten Hoeve, 2019, Front. Cell. Infect. Microbiol..

A chromatin remodelling complex that loads cohesin onto human chromosomes

R. Shiekhattar, D. Speicher, K. Yokomori, 2002, Nature.

A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment

A. Bougdour, P. Ortet, M. Barakat, 2020, Nature Microbiology.

Functional Interplay between Histone Demethylase and Deacetylase Enzymes

Min Gyu Lee, R. Shiekhattar, Neil Cooch, 2006, Molecular and Cellular Biology.

Toxoplasma gondii gene expression is under the control of regulatory pathways acting through chromatin structure.

L. Braun, D. Cannella, Mohamed-Ali Hakimi, 2008, Parasite.

Histone-Modifying Complexes Regulate Gene Expression Pertinent to the Differentiation of the Protozoan Parasite Toxoplasma gondii

Aaron T. Smith, J. Garin, M. Hakimi, 2005, Molecular and Cellular Biology.

Molecular Microbiology

A. Galinier, J. Escalante‐Semerena, R. Harshey, 2004, Journal of Clinical Pathology.

A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

A. Bougdour, Y. Couté, M. Hakimi, 2013, The Journal of experimental medicine.

The small ubiquitin-like modifier (SUMO)-conjugating system of Toxoplasma gondii.

J. Garin, M. Hakimi, H. Belrhali, 2009, International journal for parasitology.

Recombinant expression, purification, and crystallization of the glutaminyl-tRNA synthetase from Toxoplasma gondii.

M. Hakimi, H. Belrhali, J. V. van Rooyen, 2015, Protein expression and purification.

SET8-Mediated Methylations of Histone H4 Lysine 20 Mark Silent Heterochromatic Domains in Apicomplexan Genomes

J. Garin, O. Bastien, M. Hakimi, 2007, Molecular and Cellular Biology.

Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

A. Bougdour, Y. Couté, V. Josserand, 2016, The Journal of experimental medicine.

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

A. Bougdour, K. Harlos, N. Malhotra, 2023, PLoS pathogens.

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

A. Bougdour, N. Malhotra, M. Hakimi, 2022, PLoS pathogens.

Fission Yeast Homologs of Human Histone H3 Lysine 4 Demethylase Regulate a Common Set of Genes with Diverse Functions*

Min Gyu Lee, R. Shiekhattar, S. Grewal, 2006, Journal of Biological Chemistry.

Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation

A. Shilatifard, R. Shiekhattar, J. Epstein, 2005, Nature Cell Biology.

Epigenetics in Apicomplexa: control of gene expression during cell cycle progression, differentiation and antigenic variation.

M. Hakimi, K. Deitsch, Mohamed-Ali Hakimi, 2007, Current opinion in microbiology.

componentsARGONAUTE-binding platforms in RNAi-related Reiterated WG/GW motifs form functionally and evolutionarily

S. Jacobsen, Claire Picart, D. Pontier, 2007 .

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

Rebecca D. Oppenheim, J. Kloehn, Y. Couté, 2020, BMC Biology.

Transcription Factor IIB (TFIIB)-Related Protein (pBrp), a Plant-Specific Member of the TFIIB-Related Protein Family

S. Lerbs-Mache, E. Lam, D. Grunwald, 2003, Molecular and Cellular Biology.

The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages.

A. Bougdour, Y. Couté, M. Hakimi, 2022, Cell host & microbe.

Toxoplasma's ways of manipulating the host transcriptome via secreted effectors.

A. Bougdour, M. Hakimi, Mohamed-Ali Hakimi, 2015, Current opinion in microbiology.

Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replication

M. Hakimi, R. Flynn, E. Marshall, 2011, Veterinary research.

Evidence for ARGONAUTE4–DNA interactions in RNA-directed DNA methylation in plants

Christopher J. Hale, S. Jacobsen, S. Feng, 2016, Genes & development.

Linking transcriptional elongation and messenger RNA export to metastatic breast cancers.

R. Shiekhattar, Xiaowei Chen, Neil Cooch, 2005, Cancer research.

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist

A. Bougdour, U. Kapp, A. Palencia, 2017, Structure.

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

A. Bougdour, Y. Couté, M. Hakimi, 2018, eLife.

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

P. Rosenthal, A. Bougdour, S. Cusack, 2017, EMBO molecular medicine.

Effectors produced by rhoptries and dense granules: an intense conversation between parasite and host in many languages

J. Boothroyd, M. Hakimi, Mohamed-Ali Hakimi, 2020 .

Epigenetic mechanisms regulate stage differentiation in the minimized protozoan Giardia lamblia

A. Hehl, H. Rehrauer, A. Caflisch, 2010, Molecular microbiology.

is central to Toxoplasma’s manipulation

L. Braun, D. Mukhopadhyay, J. Saeij, 2019 .

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole.

G. Bett, S. Sidik, Sebastian Lourido, 2015, Cell host & microbe.

A Complex Small RNA Repertoire Is Generated by a Plant/Fungal-Like Machinery and Effected by a Metazoan-Like Argonaute in the Single-Cell Human Parasite Toxoplasma gondii

O. Voinnet, D. Cannella, Mohamed-Ali Hakimi, 2010, PLoS pathogens.

A complex small RNA repertoire is genereted by a plant/fungal-lide machinery and effected by a metazoan-like argonaute in the single-cell human parasite Toxoplasma gondii

O. Voinnet, M. Barakat, O. Bastien, 2020 .

Do apicomplexan parasites hijack the host cell microRNA pathway for their intracellular development?

R. Ménard, M. Hakimi, Mohamed-Ali Hakimi, 2010, F1000 biology reports.

A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection

M. Hakimi, D. Cannella, H. Pelloux, 2021, BMC biology.

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division

F. Lafont, M. Hakimi, G. Langsley, 2017, PLoS pathogens.

Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA.

R. Shiekhattar, T. Yoshimoto, P. Bolufer, 1995, Genomics.

Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase

A. Bougdour, C. Mas, Y. Couté, 2022, Science Translational Medicine.

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

A. Bougdour, C. Mas, Y. Couté, 2021 .

The histone methylase KMTox interacts with the redox‐sensor peroxiredoxin‐1 and targets genes involved in Toxoplasma gondii antioxidant defences

J. Garin, P. Ortet, O. Bastien, 2009, Molecular microbiology.

In vitro production of cat-restricted Toxoplasma pre-sexual stages

A. Hehl, D. Cannella, C. Swale, 2023, Nature.

Toxoplasma Parasite Twisting Motion Mechanically Induces Host Cell Membrane Fission to Complete Invasion within a Protective Vacuole.

A. Dufour, B. Touquet, M. Balland, 2018, Cell host & microbe.

Evolutionary Conservation of C-terminal Domains of Primary Sigma70-type Transcription Factors between Plants and Bacteria*

S. Lerbs-Mache, M. Hakimi, J. Valay, 2000, The Journal of Biological Chemistry.

Activity of the Histone Deacetylase Inhibitor FR235222 on Toxoplasma gondii: Inhibition of Stage Conversion of the Parasite Cyst Form and Study of New Derivative Compounds

D. Maubon, H. Pelloux, M. Brenier-Pinchart, 2010, Antimicrobial Agents and Chemotherapy.

Intraplastidial trafficking of a phage-type RNA polymerase is mediated by a thylakoid RING-H2 protein

S. Lerbs-Mache, P. Jaiswal, L. Marechal-Drouard, 2008, Proceedings of the National Academy of Sciences.

How Fitch-Margoliash Algorithm can Benefit from Multi Dimensional Scaling

Olivier Bastien, Eric Maréchal, Sylvain Lespinats, 2011, Evolutionary bioinformatics online.

Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides.

H. Vial, A. Bougdour, Y. Wong, 2013, The Journal of organic chemistry.

UAP56 associates with DRM2 and is localized to chromatin in Arabidopsis

J. Azevedo, Claire Picart, Laurent Dureau, 2019, FEBS open bio.

Hunger games in the host cell: Toxoplasma traps and skins host mitochondria.

Mohamed-Ali Hakimi, 2022, Cell host & microbe.

A Critical Role for Toxoplasma gondii Vacuolar Protein Sorting VPS9 in Secretory Organelle Biogenesis and Host Infection

C. Slomianny, M. Hakimi, G. Langsley, 2016, Scientific Reports.

Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites

A. Bougdour, M. Hakimi, S. Georgeault, 2020, iScience.

Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein.

M. Bergdoll, O. Voinnet, D. Pontier, 2010, Genes & development.

The Toxoplasma gondii F-Box Protein L2 Functions as a Repressor of Stage Specific Gene Expression

Elisabet Gas-Pascual, Mohamed-Ali Hakimi, S. Abel, 2024, PLoS pathogens.

Characterization of Arabidopsisplastid sigma-like transcription factors SIG1, SIG2 and SIG3

S. Lerbs-Mache, M. Hakimi, I. Privat, 2003, Plant Molecular Biology.

Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination.

A. Barragan, Martin Säflund, Mohamed-Ali Hakimi, 2024, mBio.