Sharon M. Sweitzer

发表

A tale of two subunits: how the neomorphic R132H IDH1 mutation enhances production of αHG.

Joseph G Boyer, R. Wooster, K. Brown, 2011, Biochemistry.

Tyrosine phosphorylation of DNA binding proteins by multiple cytokines.

D. S. Webb, E. Petricoin, G. Feldman, 1993, Science.

Characterization of a Stat-like DNA Binding Activity in Drosophila melanogaster(*)

M. Kraus, A. Larner, D. Finbloom, 1995, The Journal of Biological Chemistry.

Cloning, expression, and initial characterization of a novel cytokine-like gene family.

Michael A. Briggs, G. Rose, B. Wolf, 2002, Genomics.

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

F. Jiang, Beth L. Pietrak, T. Riera, 2014, Nature Communications.

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Dudley Lamming, D. Sinclair, K. Howitz, 2013, Science.

Dynamin Mediates Membrane Vesiculation

J. Hinshaw, S. Sweitzer, Sharon M. Sweitzer, 1998, Microscopy and Microanalysis.

Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation

J. Hinshaw, S. Sweitzer, Sharon M. Sweitzer, 1998, Cell.

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

D. Sinclair, K. Howitz, J. Moss, 2022 .

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Gang Yao, Bing Xia, Jing Chai, 2017, Nature Communications.

Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines*

J. Trill, C. Dingwall, J. Skehel, 2001, The Journal of Biological Chemistry.

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Neysa Nevins, R. Annan, D. Mcnulty, 2007, Nature chemical biology.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.

Nicholas D. Adams, S. Thrall, C. Duraiswami, 2013, Biochemistry.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Robert H Bates, G. Besra, J. Lelièvre, 2017, Nature Communications.

Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon α Transmembrane Signaling (*)

R. Buller, O. Colamonici, S. Sweitzer, 1995, The Journal of Biological Chemistry.

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

Zhong Zhong, T. Riera, S. Sweitzer, 2012, PloS one.

In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor.

R. Mayer, D. Behm, S. Sweitzer, 2013, Prostaglandins & other lipid mediators.

Development and Validation of Reagents and Assays for EZH2 Peptide and Nucleosome High-Throughput Screens

S. Thrall, G. Hofmann, L. Lafrance, 2012, Journal of biomolecular screening.

Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases

G. A. Bezerra, L. Shewchuk, A. Bochkarev, 2012, PloS one.

Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity

Leanna E. Shuster, K. Evans, S. Sweitzer, 2015, Molecular Pharmacology.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Brian Clarke, Phil Jeffrey, P. Jeffrey, 2008, Journal of medicinal chemistry.

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

C. Dingwall, J. Mosley, P. Rowland, 2010, Bioorganic & medicinal chemistry letters.

Identi fi cation of Purines and 7 ‐ Deazapurines as Potent and Selective Type I Inhibitors of Troponin I ‐ Interacting Kinase ( TNNI 3 K )

D. Holt, A. P. Graves, L. Shewchuk, 2015 .

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells.

Marc A. Holbert, Yong Jiang, S. Sweitzer, 2014, Protein expression and purification.

Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity

Leanna E. Shuster, K. Evans, C. Buser, 2015, Molecular Pharmacology.

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

R. Annan, D. Mcnulty, R. Copeland, 2011, The Biochemical journal.

Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system

P. McAllister, J. Trill, J. Kane, 2004, Cytotechnology.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Methyltransferases prefer monomer over core-trimmed nucleosomes as in vitro substrates.

S. Thrall, Yong Jiang, S. Sweitzer, 2011, Analytical biochemistry.

Mapping of a Cytoplasmic Domain of the Human Growth Hormone Receptor That Regulates Rates of Inactivation of Jak2 and Stat Proteins*

G. Feldman, Y. Wang, W. Wood, 1997, The Journal of Biological Chemistry.

A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1

R. Annan, A. P. Graves, D. Mcnulty, 2018, SLAS discovery : advancing life sciences R & D.