H. Kostrhunová

发表

An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis

V. Brabec, J. Kašpárková, Z. Trávníček, 2019, Scientific Reports.

Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

V. Brabec, J. Kašpárková, R. Phillips, 2020, Angewandte Chemie.

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification† †Electronic supplementary information (ESI) available: Data created during this study are openly available from the University of Warwick Research Archive Portal (WRAP) (http://wrap.warwic

V. Brabec, L. Young, R. Phillips, 2019, Chemical science.

New Acridine Thiourea Gold(I) Anticancer Agents: Targeting the Nucleus and Inhibiting Vasculogenic Mimicry.

V. Brabec, H. Kostrhunova, A. Zamora, 2017, ACS chemical biology.

Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes

V. Brabec, N. Farrell, J. Kašpárková, 2016, Scientific Reports.

Different affinity of nuclear factor‐kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer

V. Brabec, J. Kašpárková, P. Midoux, 2014, The FEBS journal.

A Cyclometalated IrIII Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells.

V. Brabec, J. Kašpárková, H. Kostrhunova, 2021, Chemistry.

Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far-Red Emitting Coumarin.

V. Brabec, J. Kašpárková, S. Nonell, 2019, Angewandte Chemie.

Copper(ii) complexes with tridentate Schiff base-like ligands: solid state and solution structures and anticancer activity.

V. Brabec, Florian Schmitt, R. Schobert, 2019, Dalton transactions.

Synthesis, antiproliferative activity in cancer cells and DNA interaction studies of [Pt(cis-1,3-diaminocycloalkane)Cl2] analogs

V. Brabec, J. Kašpárková, O. Novakova, 2020, JBIC Journal of Biological Inorganic Chemistry.

Oxidation of cis-diamminediacetato Pt(II) with hydrogen peroxide can give rise to two isomeric Pt(IV) products.

D. Gibson, H. Kostrhunova, M. Ishan, 2020, Chemistry.

An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects.

V. Brabec, J. Kašpárková, D. Gibson, 2019, Chemistry.

Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells.

V. Brabec, J. Kašpárková, Z. Trávníček, 2018, Dalton transactions.

Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents.

V. Brabec, J. Kašpárková, C. Janiak, 2018, Chemistry.

"Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes.

P. Sadler, V. Brabec, A. Habtemariam, 2016, Dalton transactions.

Valuable insight into the anticancer activity of the platinum-histone deacetylase inhibitor conjugate, cis-[Pt(NH3)2malSAHA-2H)].

V. Brabec, J. Kašpárková, H. Kostrhunova, 2012, Molecular pharmaceutics.

Cellular response to antitumor cis-Dichlorido platinum(II) complexes of CDK inhibitor Bohemine and its analogues.

V. Brabec, O. Novakova, Z. Trávníček, 2012, Chemical research in toxicology.

(Carboxydiamine)Pt(II) complexes of a combretastatin A-4 analogous chalcone: the influence of the diamine ligand on DNA binding and anticancer effects

Aamir Ahmad, F. Sarkar, V. Brabec, 2011 .

Metallohelices stabilize DNA three-way junctions and induce DNA damage in cancer cells

V. Brabec, J. Malina, Peter Scott, 2023, Nucleic acids research.

Fe(II) metallohelices stabilize DNA G-quadruplexes and down-regulate expression of G-quadruplex regulated oncogenes.

V. Brabec, J. Malina, P. Scott, 2021, Chemistry.

Different features of the DNA binding mode of antitumor cis-amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro.

V. Brabec, J. Kašpárková, T. Suchánková, 2010, Chemical research in toxicology.

Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells

V. Brabec, J. Malina, Hualong Song, 2023, Journal of enzyme inhibition and medicinal chemistry.

Metallohelix vectors for efficient gene delivery via cationic DNA nanoparticles

V. Brabec, H. Kostrhunova, J. Malina, 2022, Nucleic acids research.

Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin.

V. Brabec, J. Kašpárková, D. Gibson, 2016, Journal of inorganic biochemistry.

Platinum(IV)-Estramustine Multiaction Prodrugs Are Effective Antiproliferative Agents against Prostate Cancer Cells.

V. Brabec, D. Gibson, H. Kostrhunova, 2020, Journal of medicinal chemistry.

A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases.

V. Brabec, J. Kašpárková, O. Novakova, 2015, Angewandte Chemie.

Novel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action

V. Brabec, J. Kašpárková, H. Kostrhunova, 2022, Bioinorganic chemistry and applications.

Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells

V. Brabec, J. Kašpárková, O. Novakova, 2023, Journal of medicinal chemistry.

A [Pt(cis-1,3-diaminocycloalkane)Cl2] analog exhibits hallmarks typical of immunogenic cell death inducers in model cancer cells.

V. Brabec, J. Kašpárková, J. Hoeschele, 2021, Journal of inorganic biochemistry.

A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death

V. Brabec, J. Kašpárková, H. Kostrhunova, 2021, Inorganic Chemistry Frontiers.

Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells.

V. Brabec, J. Kašpárková, Z. Trávníček, 2018, Dalton Transactions.

A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex.

P. Sadler, V. Brabec, J. Kašpárková, 2014, Metallomics : integrated biometal science.

Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates.

V. Brabec, H. Kostrhunova, H. Kostrhunová, 2000, Biochemistry.

Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.

Amanda J. Pickard, V. Brabec, J. Kašpárková, 2011, Molecular pharmaceutics.

DNA modification by cisplatin-like Pt(II) complexes containing 1,1′-binaphtyl-2,2′-diamine ligand does not correlate with their antiproliferative activity in cancer cells

V. Brabec, J. Kašpárková, O. Novakova, 2019, Inorganica Chimica Acta.

DNA bending and unwinding due to the major 1, 2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent

Jana Kasparkova, Viktor Brabec, Kristyna Stehlikova, 2002, Nucleic Acids Res..

Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione.

V. Brabec, J. Kašpárková, D. Gibson, 2010, Molecular pharmaceutics.

Antitumor substitution-inert polynuclear platinum complexes stabilize G-quadruplex DNA and suppress G-quadruplex-mediated gene expression

V. Brabec, N. Farrell, H. Kostrhunova, 2021 .

Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis

V. Brabec, J. Kašpárková, H. Kostrhunova, 2023, Inorganic chemistry.

Functionalization of osmium arene anticancer complexes with (poly)arginine: effect on cellular uptake, internalization, and cytotoxicity.

P. Sadler, V. Brabec, S. V. Rijt, 2011, Bioconjugate chemistry.

Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action.

V. Brabec, J. Kašpárková, J. Ruiz, 2017, Chemistry.

Mechanistic insights into antitumor effects of new dinuclear cis Pt(II) complexes containing aromatic linkers.

V. Brabec, J. Kašpárková, O. Novakova, 2010, Biochemical pharmacology.

N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity.

J. Kašpárková, G. Pampaloni, L. Biancalana, 2023, Chemico-biological interactions.

DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media.

Anna F. A. Peacock, P. Sadler, V. Brabec, 2008, Journal of medicinal chemistry.

Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents.

V. Brabec, N. Farrell, J. Kašpárková, 2004, Biochemistry.

A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton.

V. Brabec, J. Kašpárková, J. Aldrich-Wright, 2019, Journal of medicinal chemistry.

Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand

V. Brabec, J. Kašpárková, P. Buglyó, 2020, JBIC Journal of Biological Inorganic Chemistry.

Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity.

V. Brabec, P. Dyson, F. Marchetti, 2021, Inorganic chemistry.

Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?

V. Brabec, V. Gandin, D. Gibson, 2021, Journal of medicinal chemistry.