A. Mahul-Mellier

发表

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

S. Grimm, L. Huc, E. Pazarentzos, 2011, Cell Death and Differentiation.

Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo

D. D. Di Monte, H. Lashuel, A. Chiki, 2023, bioRxiv.

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

G. Knott, H. Lashuel, J. Burtscher, 2020, Proceedings of the National Academy of Sciences.

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1

H. Lashuel, A. Chiki, G. Dietler, 2021, bioRxiv.

Towards deciphering the Nt17 code: How the sequence and conformation of the first 17 amino acids in Huntingtin regulate the aggregation, cellular properties and neurotoxicity of mutant Httex1

H. Lashuel, A. Chiki, G. Dietler, 2021 .

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

G. Knott, H. Lashuel, J. Burtscher, 2020, Nature Communications.

Disentangling the sequence, cellular and ultrastructural determinants of Huntingtin nuclear and cytoplasmic inclusion formation

G. Knott, H. Lashuel, J. Burtscher, 2020 .

Alix, Making a Link between Apoptosis-Linked Gene-2, the Endosomal Sorting Complexes Required for Transport, and Neuronal Death In Vivo

B. Blot, R. Sadoul, S. Fraboulet, 2006, The Journal of Neuroscience.

Alix and ALG-2 make a link between endosomes and neuronal death.

F. Strappazzon, A. Petiot, B. Blot, 2009, Biochemical Society transactions.

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

D. Muller, M. Roo, H. Lashuel, 2015, Cell Death and Differentiation.

The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is the major driver of neurodegeneration in synucleinopathies

G. Knott, H. Lashuel, J. Burtscher, 2019, bioRxiv.

A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity

H. Lashuel, F. Sobott, Rani Moons, 2022, Science advances.

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease

Paul M. Levine, H. Lashuel, Matthew R. Pratt, 2019, Proceedings of the National Academy of Sciences.

The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity*

H. Lashuel, D. Eliezer, G. Dietler, 2014, The Journal of Biological Chemistry.

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

E. Masliah, O. Hantschel, G. Halliday, 2014, Human molecular genetics.

IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF‐κB retention

S. Grimm, E. Pazarentzos, N. Mazarakis, 2014, The EMBO journal.

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies.

H. Lashuel, L. Forró, B. Maco, 2016, Toxicology research.

Alix and ALG-2 Are Involved in Tumor Necrosis Factor Receptor 1-induced Cell Death*

J. Garin, F. Strappazzon, A. Petiot, 2008, Journal of Biological Chemistry.

Fis1 and Bap31 bridge the mitochondria–ER interface to establish a platform for apoptosis induction

S. Grimm, E. Pazarentzos, Anne-Laure Mahul-Mellier, 2011, The EMBO journal.

De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF

S. Grimm, E. Pazarentzos, Anne-Laure Mahul-Mellier, 2011, Cell Death and Differentiation.

Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers

S. Grimm, S. Irshad, A. Lemarié, 2009, Cell Death and Differentiation.

Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy

H. Lashuel, T. Lasser, E. Bostan, 2018, Nature Photonics.

Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy

H. Lashuel, T. Lasser, E. Bostan, 2017, 1705.05766.

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

T. Walz, H. Lashuel, D. Eliezer, 2017, Nature Communications.

The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1.

H. Lashuel, A. Chiki, G. Dietler, 2021, Journal of molecular biology.

Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer

Jimmy D Bell, A. Boobis, M. El-Bahrawy, 2016, Oncotarget.

The making of a Lewy body: the role of α-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions

G. Knott, C. Strand, M. Citron, 2018, bioRxiv.

A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity

H. Lashuel, F. Sobott, Rani Moons, 2021, bioRxiv.

Amyloid single-cell cytotoxicity assays by nanomotion detection

H. Lashuel, G. Dietler, G. Longo, 2017, Cell Death Discovery.

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

A. Gitler, H. Lashuel, D. Eliezer, 2016, ACS chemical biology.

De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1.

S. Grimm, E. Pazarentzos, Anne-Laure Mahul-Mellier, 2012, Biochimica et biophysica acta.

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

N. Guex, H. Lashuel, C. Iseli, 2022, npj Parkinson's Disease.

Fis1 and Bap31 bridge the mitochondria–ER interface to establish a platform for apoptosis induction

S. Grimm, E. Pazarentzos, C. Datler, 2011, The EMBO journal.

Disentangling the sequence, cellular and ultrastructural determinants of Huntingtin nuclear and cytoplasmic inclusion formation

G. Knott, H. Lashuel, J. Burtscher, 2020 .

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

Virginia M. Y. Lee, H. Lashuel, K. Luk, 2023, bioRxiv.

De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1.

S. Grimm, E. Pazarentzos, A. Mahul-Mellier, 2012, Biochimica et biophysica acta.

O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.

Matthew R. Pratt, S. Afrin, L. Saelices, 2024, Nature chemical biology.