Richard Gowan

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Alan R. Saltiel, A. Bridges, W. Leopold, 1999, Nature Medicine.

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).

J. Warmus, A. Bridges, W. Leopold, 2008, Bioorganic & medicinal chemistry letters.

Synergy between Anions and Farnesyldiphosphate Competitive Inhibitors of Farnesyl:Protein Transferase*

D. Hupe, J. Sebolt-Leopold, J. Scholten, 1997, The Journal of Biological Chemistry.

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Daniel F Ortwine, J. A. Spicer, W. Denny, 2007, Journal of medicinal chemistry.

Inhibitors of farnesyl:protein transferase--a possible cancer chemotherapeutic.

D. Hupe, J. Sebolt-Leopold, J. Scholten, 1996, Bioorganic & medicinal chemistry.

Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.

A. Doherty, J. Sebolt-Leopold, J. C. Hodges, 1997, Journal of medicinal chemistry.

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.

Mostofa A Hena, B. Finzel, R. Gilbertsen, 2012, Bioorganic & medicinal chemistry letters.

Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.

J. Pandit, C. Whitehead, Cindy Spessard, 2013, Bioorganic & medicinal chemistry letters.