Jurgen Pleiss

发表

The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation

Sara Weirich, Alexander Bröhm, P. Bashtrykov, 2023, bioRxiv.

Preferential self-interaction of DNA methyltransferase DNMT3A subunits containing the R882H cancer mutation leads to dominant changes of flanking sequence preferences.

A. Jeltsch, Sabrina Adam, P. Bashtrykov, 2022, Journal of molecular biology.

Rational Design of a Minimal and Highly Enriched CYP102A1 Mutant Library with Improved Regio‐, Stereo‐ and Chemoselectivity

Sabine Laschat, S. Laschat, V. Urlacher, 2009, Chembiochem : a European journal of chemical biology.

Selective Catalytic Oxidation of CH Bonds with Molecular Oxygen

G. Sprenger, S. Laschat, V. Urlacher, 2013 .

Multiple molecular dynamics simulations of human p450 monooxygenase CYP2C9: The molecular basis of substrate binding and regioselectivity toward warfarin

Jürgen Pleiss, Stephan Tatzel, J. Pleiss, 2006, Proteins.

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

M. Eichelbaum, M. Schwab, U. Zanger, 2004, Journal of Pharmacology and Experimental Therapeutics.

Identification of selectivity‐determining residues in cytochrome P450 monooxygenases: A systematic analysis of the substrate recognition site 5

Alexander Seifert, J. Pleiss, Alexander Seifert, 2009, Proteins.

A Natural Variant of the Heme-Binding Signature (R441C) Resulting in Complete Loss of Function of CYP2D6

M. Eichelbaum, U. Zanger, E. Hustert, 2007, Drug Metabolism and Disposition.

Congenital adrenal hyperplasia: the molecular basis of 21-hydroxylase deficiency in H-2(aw18) mice.

W. Sippell, N. Krone, J. Pleiss, 2005, Endocrinology.

DMD # 15149 1 A Natural Variant of the Heme-Binding Signature ( R 441 C ) Resulting in Complete Loss of Function of CYP 2 D 6

M. Eichelbaum, U. Zanger, E. Hustert, 2007 .

Immobilization of P450 BM-3 monooxygenase on mesoporous molecular sieves with different pore diameters

V. Urlacher, R. Gläser, M. Hunger, 2010 .

An Efficient Route to Selective Bio‐oxidation Catalysts: an Iterative Approach Comprising Modeling, Diversification, and Screening, Based on CYP102A1

B. Hauer, Mihaela Antonovici, Alexander Seifert, 2011, Chembiochem : a European journal of chemical biology.

Anchoring effects in a wide binding pocket: The molecular basis of regioselectivity in engineered cytochrome P450 monooxygenase from B. megaterium

M. Budde, V. Urlacher, M. Ramos, 2008, Proteins.

Rational Design of a Minimal and Highly Enriched CYP102A1 Mutant Library with Improved Regio‐, Stereo‐ and Chemoselectivity

S. Laschat, V. Urlacher, Alexander Seifert, 2009 .

Screening of a minimal enriched P450 BM3 mutant library for hydroxylation of cyclic and acyclic alkanes.

Vlada B Urlacher, V. Urlacher, Mihaela Antonovici, 2011, Chemical communications.

Mechanistic basis of the increased methylation activity of the SETD2 protein lysine methyltransferase towards a designed super-substrate peptide

Sara Weirich, J. Pleiss, A. Jeltsch, 2022, Communications Chemistry.