Anna Pensalfini

发表

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

R. Nixon, C. Bleiwas, C. Bouchet-Marquis, 2022, Nature Neuroscience.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

A causative link between the structure of aberrant protein oligomers and their toxicity.

Fabrizio Chiti, Christopher M Dobson, Silvia Campioni, 2010, Nature chemical biology.

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

C. Glabe, I. Bernstein, E. Funai, 2014, Science Translational Medicine.

Dysfunction of autophagy and endosomal‐lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

R. Nixon, A. Pensalfini, Ying Jiang, 2018, Free radical biology & medicine.

Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo

R. Nixon, Dun-sheng Yang, T. Yoshimori, 2018, Autophagy.

Preclinical and Clinical Studies of p38α MAP kinase inhibition to Treat Basal Forebrain Cholinergic Dysfunction and Degeneration

P. Scheltens, P. Maruff, N. Prins, 2021 .

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.

J. Smiley, R. Nixon, Ju-Hyun Lee, 2020, Cell reports.

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques

C. Kawas, M. Corrada, C. Glabe, 2014, Neurobiology of Disease.

Intracellular Injection of Brain Extracts from Alzheimer’s Disease Patients Triggers Unregulated Ca2+ Release from Intracellular Stores That Hinders Cellular Bioenergetics

G. Ullah, I. Parker, A. Demuro, 2022, bioRxiv.

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

L. Breydo, F. LaFerla, R. Kayed, 2012, Molecular Neurodegeneration.

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

J. Marsh, L. Breydo, I. Canto, 2010, Molecular Neurodegeneration.

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

C. Glabe, E. Head, Jennifer L. Tomic, 2009, Neurobiology of Disease.

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer*

R. Kayed, C. Glabe, E. Head, 2009, Journal of Biological Chemistry.

A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells.

A. Gliozzi, M. Stefani, Daniela Nichino, 2009, Biochimica et biophysica acta.

Atomic View of a Toxic Amyloid Small Oligomer

David Eisenberg, Meytal Landau, Duilio Cascio, 2012, Science.

Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity

M. Stefani, D. Nosi, M. Ruggiero, 2008, Journal of Molecular Medicine.

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease

R. Nixon, A. Pensalfini, Seonil Kim, 2015, Molecular Psychiatry.

Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways

M. Memo, D. Uberti, A. Pensalfini, 2010, Amino Acids.

New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc

S. Sensi, V. Frazzini, A. Pensalfini, 2011, Cell Death and Disease.

Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF‐N aggregates to different cell types

L. Formigli, M. Stefani, R. Caporale, 2006, The FEBS journal.

Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates

M. Bucciantini, M. Stefani, D. Nosi, 2005, Journal of Cell Science.

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

D. Eisenberg, M. Sawaya, J. Nowick, 2012, Proceedings of the National Academy of Sciences.

Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content

L. Formigli, M. Stefani, D. Nosi, 2008, Journal of cellular and molecular medicine.

Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts

S. Sorbi, B. Nacmias, D. Nosi, 2007, Neurobiology of Aging.

Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress.

S. Sorbi, B. Nacmias, P. Paoli, 2008, Free radical biology & medicine.

Differentiation Increases the Resistance of Neuronal Cells to Amyloid Toxicity

L. Formigli, M. Stefani, D. Nosi, 2008, Neurochemical Research.

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration

P. Scheltens, P. Maruff, H. Chu, 2022, Nature Communications.

Membrane cholesterol enrichment prevents Aβ-induced oxidative stress in Alzheimer's fibroblasts

S. Sorbi, B. Nacmias, S. Bagnoli, 2011, Neurobiology of Aging.

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

M. Memo, S. Sorbi, B. Nacmias, 2010, Journal of Molecular Medicine.

Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways

M. Memo, G. Cenini, D. Uberti, 2009, Amino Acids.

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer*

R. Kayed, C. Glabe, E. Head, 2009, Journal of Biological Chemistry.

Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways.

G. Donzelli, M. Becatti, A. Pensalfini, 2008, Free radical biology & medicine.

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

J. Marsh, L. Breydo, R. Kayed, 2010, Molecular Neurodegeneration.

Assessing Rab5 Activation in Health and Disease.

R. Nixon, A. Pensalfini, Seonil Kim, 2021, Methods in molecular biology.