Juha R. Savinainen

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Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain

R. Giniatullin, J. Savinainen, Adriana Della Pietra, 2022, International journal of molecular sciences.

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications.

N. Grimsey, B. Attili, J. Savinainen, 2020, Drug discovery today.

Synthesis and preclinical evaluation of [11C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL).

Guy Bormans, Sofie Celen, Alfons Verbruggen, 2017, European journal of medicinal chemistry.

In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048)

J. Laitinen, T. Nevalainen, M. Lehtonen, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Loratadine analogues as MAGL inhibitors.

Tuomo Laitinen, T. Laitinen, J. Laitinen, 2015, Bioorganic & medicinal chemistry letters.

Optimization of 1,2,5‐Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors

F. Maxfield, T. Laitinen, R. Runyon, 2015, ChemMedChem.

Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

T. Laitinen, J. Laitinen, T. Nevalainen, 2014, Bioorganic & medicinal chemistry.

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

J. Leppänen, A. Poso, T. Laitinen, 2013, Journal of medicinal chemistry.

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.

A. Poso, T. Laitinen, J. Laitinen, 2013, Chemistry & biology.

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

J. Laitinen, S. Saario, J. Savinainen, 2012, Acta physiologica.

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

V. Leinonen, A. M. van den Maagdenberg, M. Lehtonen, 2023, The Journal of Headache and Pain.

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.

S. Fogli, A. Malfitano, V. Di Marzo, 2015, European journal of medicinal chemistry.

Screening of Various Hormone‐Sensitive Lipase Inhibitors as Endocannabinoid‐Hydrolyzing Enzyme Inhibitors

Henri Xhaard, Antti Poso, Jukka Leppänen, 2009, ChemMedChem.

Identification of WIN55212‐3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor

Antti Poso, Tomi Järvinen, A. Poso, 2005, British journal of pharmacology.

Despite substantial degradation, 2‐arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor‐dependent G‐protein activation in rat cerebellar membranes

J. Laitinen, T. Järvinen, J. Savinainen, 2001, British journal of pharmacology.

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors

J. Laitinen, T. Järvinen, S. Saario, 2003, British journal of pharmacology.

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

M. Varjosalo, T. Wirth, J. Laitinen, 2020, Biological Procedures Online.

Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections – Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils

M. Varjosalo, T. Wirth, J. Laitinen, 2019, bioRxiv.

S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner

T. Kokkola, J. Laitinen, Juha R Savinainen, 2005, BMC Cell Biology.

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

S. Haggarty, H. Huttunen, M. C. Silva, 2023, Science Translational Medicine.

Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine

R. Giniatullin, J. Savinainen, Adriana Della Pietra, 2021, International journal of molecular sciences.

Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β-Hydrolase Domain 6 (ABHD6).

W. Vanduffel, G. Bormans, G. Cowin, 2022, Journal of medicinal chemistry.

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.

J. Laitinen, T. Järvinen, S. Saario, 2004, Biochemical pharmacology.

3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.

Antti Poso, Tomi Järvinen, Maija Lahtela-Kakkonen, 2006, Journal of medicinal chemistry.

Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)

T. Laitinen, J. Laitinen, T. Nevalainen, 2014, PloS one.

1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.

A. Malfitano, V. Di Marzo, A. Ligresti, 2014, European journal of medicinal chemistry.

Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.

T. Laitinen, J. Laitinen, T. Nevalainen, 2015, Bioorganic & medicinal chemistry.

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)[S]

J. Laitinen, J. Savinainen, Dina Navia-Paldanius, 2012, Journal of Lipid Research.

Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells.

A. Poso, T. Laitinen, J. Laitinen, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human α/β-hydrolase domain containing 11 (ABHD11).

T. Laitinen, J. Laitinen, T. Nevalainen, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice.

J. Laitinen, M. Lehtonen, Casandra Riera Ribas, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability.

J. Laitinen, T. Nevalainen, S. Saario, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE).

A. Poso, J. Laitinen, T. Nevalainen, 2006, Bioorganic & medicinal chemistry.

Effects of Topical Anandamide-Transport Inhibitors, AM404 and Olvanil, on Intraocular Pressure in Normotensive Rabbits

K. Järvinen, J. Laitinen, T. Järvinen, 2001, Pharmaceutical Research.

Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL)

A. Poso, T. Laitinen, J. Laitinen, 2014, Molecular Pharmacology.

Mutation of Cys242 of Human Monoacylglycerol Lipase Disrupts Balanced Hydrolysis of 1- and 2-Monoacylglycerols and Selectively Impairs Inhibitor Potency

A. Poso, T. Laitinen, J. Laitinen, 2014, Molecular Pharmacology.

Discovery of Triterpenoids as Reversible Inhibitors of α/β-hydrolase Domain Containing 12 (ABHD12)

T. Laitinen, J. Laitinen, S. Alakurtti, 2014, PloS one.

Mutation of Cys 242 of Human Monoacylglycerol Lipase Disrupts Balanced Hydrolysis of 1-and 2-Monoacylglycerols and Selectively Impairs Inhibitor Potency s

A. Poso, T. Laitinen, J. Laitinen, 2014 .

Mutation of Cys242 of Human Monoacylglycerol Lipase Disrupts Balanced Hydrolysis of 1-and 2-monoacylglycerols and Selectively Impairs Inhibitor Potency Running Title Page Running Title: Structural Determinants of Magl for Substrate Preference Introduction

A. Poso, T. Laitinen, J. Laitinen, 2022 .

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.

Ettore Novellino, Luciana Marinelli, Marco Macchia, 2015, European journal of medicinal chemistry.

Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.

U. Taschler, R. Zimmermann, J. Laitinen, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique.

J. Laitinen, T. Nevalainen, J. Savinainen, 2010, Analytical biochemistry.

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

A. Poso, J. Laitinen, T. Nevalainen, 2006, Journal of medicinal chemistry.

Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis

P. Nieminen, A. Mustonen, H. Kröger, 2022, Inflammation.